GTU BE 2019 Summer Question Papers || Gujarat Technological University
Subject Code: 2133601
GUJARAT TECHNOLOGICAL UNIVERSITY
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BE - SEMESTER-III (NEW) EXAMINATION — SUMMER 2019
Subject Name: Introduction to Medicinal Chemistry & Biochemistry(Elective-I)
Date: 04/06/2019
Time: 02:30 PM TO 05:00 PM
Total Marks: 70
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Instructions:
- Attempt all questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
| Q.1 | (a) | Draw the diagram of enzyme key and lock model. Explain Briefly | 03 |
| (b) | Explain Enzyme Inhibition in Detail | 04 | |
| (c) | What is Glycolysis? Explain Glycolysis in detail with ATP Synthesis | 07 | |
| Q.2 | (a) | Write the mode of action of Azole class of antifungal agent. Give one example in each class & Write the MOA of Azole antifungal agents | 03 |
| (b) | Write the SAR of Sulphonamide class of antibacterials. | 04 | |
| (c) | Discuss classification of antimalarial drugs with examples. | 07 | |
| OR | |||
| (a) | Define Harmones? Give the classification of hormones with their functions | 03 | |
| (b) | Describe the viral life cycle. | 04 | |
| (c) | What are GMPs? Why GMP is important? What are the responsibilities | 07 | |
| Q.3 | (a) | Explain the Glycolysis pathway in detail. | 03 |
| OR | |||
| (b) | Define (1). Structure- Activity Relationship (SAR), (2). Medicinal Chemistry, (3). Drug | 04 | |
| (c) | Write a note on Drug classification | 07 | |
| Q4 | (a) | Write the classifications with examples of anti-amoebic drugs. Write the MOA & Synthesis of Metronidazole. | 03 |
| (b) | Discuss Photosynthesis in detail | 04 | |
| (c) | What is the medical condition called “Gout”? How the anti-gout agents work? Give suitable example with structures. | 07 | |
| Q4 | (a) | Write the MOA, synthesis & metabolism of Ethambutol | 03 |
| OR | |||
| (b) | Write the MOA & synthesis of any one Sulphonamide drug | 04 | |
| (c) | Describe the MOA & synthesis of any one alkylating agent anti-neoplastic drug. | 07 | |
| Q.5 | (a) | Define drug metabolism. Write its importance. Describe the pathways with suitable example. | 03 |
| (b) | Write the classifications, MOA of anti HIV drugs with one example | 04 | |
| (c) | Write the SAR of 4-aminoquinoline antimalarial drugs. | 07 | |
| Q.5 | (a) | Write the mode of action of Non-Steroidal Anti Inflammatory drugs (NSAID). Write the synthesis, SAR & metabolism of any one Salicylate NSAID. | 03 |
| (b) | Explain the following terms in viral reproductive cycle: (1). Transcription, (2). Translation, (3). Reverse transcription | 04 | |
| (c) | Explain different cell organelles and their function with diagram | 07 | |