Download GTU BE/B.Tech 2019 Summer 3rd Sem New 2133601 Introduction To Medicinal Chemistry And Biochemistry Elective I Question Paper

Download GTU (Gujarat Technological University) BE/BTech (Bachelor of Engineering / Bachelor of Technology) 2019 Summer 3rd Sem New 2133601 Introduction To Medicinal Chemistry And Biochemistry Elective I Previous Question Paper

1
Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER ?III (NEW) EXAMINATION ? SUMMER 2019
Subject Code: 2133601 Date: 04/06/2019

Subject Name: Introduction to Medicinal Chemistry &
Biochemistry(Elective-I)

Time: 02:30 PM TO 05:00 PM Total Marks: 70

Instructions:

1. Attempt all questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

MARKS

Q.1 (a) Draw the diagram of enzyme key and lock model. Explain Briefly 03
(b) Explain Enzyme Inhibition in Detail 04
(c) What is Glycolysis? Explain Glycolysis in detail with
ATP Synthesis
07

Q.2 (a) Write the mode of action of Azole class of antifungal agent. Give one
example in each class & Write the MOA of Azole antifungal agents
03
(b) Write the SAR of Sulphonamide class of antibacterials. 04
(c) Discuss classification of antimalarial drugs with examples. 07
OR
(c) Define Harmones? Give the classification of hormones with their functions 07
Q.3 (a) Describe the viral life cycle. 03
(b) What are GMPs? Why GMP is important? What are the responsibilities 04
(c) Explain the Glycolysis pathway in detail. 07
OR
Q.3 (a) Define (1). Structure- Activity Relationship (SAR), (2). Medicinal
Chemistry, (3). Drug
03
(b) Write a note on Drug classification 04
(c) Write the classifications with examples of anti-amoebic drugs. Write the
MOA & Synthesis of Metronidazole.
07
Q.4 (a) Discuss Photosynthesis in detail 03
(b) What is the medical condition called ?Gout?? How the anti-gout agents
work? Give suitable example with structures.
04
(c) Write the MOA, synthesis & metabolism of Ethambutol 07
OR
Q.4 (a) Write the MOA & synthesis of any one Sulphonamide drug 03
(b) Describe the MOA & synthesis of any one alkylating agent anti-neoplastic
drug.
04
(c) Define drug metabolism. Write its importance. Describe the pathways with
suitable example.
07
Q.5 (a) Write the classifications, MOA of anti HIV drugs with one example 03
(b) Write the SAR of 4-aminoquinoline antimalarial drugs. 04
(c) Write the mode of action of Non-Steroidal Anti Inflammatory drugs
(NSAID). Write the synthesis, SAR & metabolism of any one Salicylate
NSAID.
07






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1
Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER ?III (NEW) EXAMINATION ? SUMMER 2019
Subject Code: 2133601 Date: 04/06/2019

Subject Name: Introduction to Medicinal Chemistry &
Biochemistry(Elective-I)

Time: 02:30 PM TO 05:00 PM Total Marks: 70

Instructions:

1. Attempt all questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

MARKS

Q.1 (a) Draw the diagram of enzyme key and lock model. Explain Briefly 03
(b) Explain Enzyme Inhibition in Detail 04
(c) What is Glycolysis? Explain Glycolysis in detail with
ATP Synthesis
07

Q.2 (a) Write the mode of action of Azole class of antifungal agent. Give one
example in each class & Write the MOA of Azole antifungal agents
03
(b) Write the SAR of Sulphonamide class of antibacterials. 04
(c) Discuss classification of antimalarial drugs with examples. 07
OR
(c) Define Harmones? Give the classification of hormones with their functions 07
Q.3 (a) Describe the viral life cycle. 03
(b) What are GMPs? Why GMP is important? What are the responsibilities 04
(c) Explain the Glycolysis pathway in detail. 07
OR
Q.3 (a) Define (1). Structure- Activity Relationship (SAR), (2). Medicinal
Chemistry, (3). Drug
03
(b) Write a note on Drug classification 04
(c) Write the classifications with examples of anti-amoebic drugs. Write the
MOA & Synthesis of Metronidazole.
07
Q.4 (a) Discuss Photosynthesis in detail 03
(b) What is the medical condition called ?Gout?? How the anti-gout agents
work? Give suitable example with structures.
04
(c) Write the MOA, synthesis & metabolism of Ethambutol 07
OR
Q.4 (a) Write the MOA & synthesis of any one Sulphonamide drug 03
(b) Describe the MOA & synthesis of any one alkylating agent anti-neoplastic
drug.
04
(c) Define drug metabolism. Write its importance. Describe the pathways with
suitable example.
07
Q.5 (a) Write the classifications, MOA of anti HIV drugs with one example 03
(b) Write the SAR of 4-aminoquinoline antimalarial drugs. 04
(c) Write the mode of action of Non-Steroidal Anti Inflammatory drugs
(NSAID). Write the synthesis, SAR & metabolism of any one Salicylate
NSAID.
07






2

OR
Q.5 (a) Explain the following terms in viral reproductive cycle: (1). Transcription,
(2). Translation, (3). Reverse transcription
03
(b) Explain different cell organelles and their function with diagram 04
(c) Define the term: Transamination. Discuss Urea cycle in detail 07

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