Download GTU BE/B.Tech 2019 Summer 6th Sem New 2160401 Advanced Molecular Biology Ii Question Paper

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GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER-VI(NEW) - EXAMINATION - SUMMER 2019

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Subject Code:2160401

Subject Name:Advanced Molecular Biology-11

Time:10:30 AM TO 01:00 PM

Instructions:

1. Attempt all questions.

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2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1

1. (a) Explain mismatch repair.
2. (b) What are types of mutation?

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3. (c) How can detection and selection of mutants be done?

Q.2

1. (a) What is epistasis?
2. (b) What is SOS response?
3. (c) Explain genetics of M13 virus.

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OR

1. (a) What is catabolite repression?
2. (b) Chemical mutagens.
3. (c) Explain Splicing of GU-AG intron.

Q.3

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1. (a) Explain positive and negative regulation of transcription

OR

1. (b) Draw and name the genes of Lac operon system
2. (c) Write a short note on Tn3 transposon in E.coli

Q.4

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1. (a) Draw structure of Retrovirus and explain its life cycle.

1. (b) Draw and name the genes of Trp operon system
2. (c) Draw and explain hairpin mechanism of strand cleavage and integration of TnS5.

Q.5

1. (a) Explain types of transposable elements.

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OR

1. (b) How does acetylation and phosphorylation help in gene expression regulation.
2. (c) Explain FISH for physical maps.

1. (a) What are integrons?
2. (b) Define: Allele, Genotype and phenotype.

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3. (c) What is difference between linked genes and unlinked genes?

OR

1. (a) Explain the spliciosome mediated splicing in detail.
2. (b) Write the principle of chain termination DNA sequencing.
3. (c) What is DNA fingerprinting?

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1. (a) Explain Maxam-Gilbert’s Method of DNA sequencing.

Date:10/05/2019

Total Marks: 70

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