Subject Code: 2160410
GUJARAT TECHNOLOGICAL UNIVERSITY
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SEMESTER-VI(NEW) — EXAMINATION — SUMMER 2019
Subject Name: Bioinformatics
Time: 10:30 AM TO 01:00 PM
Date: 21/05/2019
Total Marks: 70
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Instructions:
- Attempt all questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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Q.1
(a) Give the historical overview of Bioinformatics. [03]
(b) What is consensus sequence? [04]
(c) Briefly explain the role of NCBI. Further, discuss MMDB. [07]
Q.2
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(a) Enlist the tools of Entrez. [03]
(b) Write with an example: global alignment. [04]
(c) Discuss the importance of molecular biology in understanding bioinformatics. [07]
OR
(c) For what attributes, do the phylogenetic analysis help? [07]
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Q.3
(a) What is cladistics and systematics? [03]
(b) How is the score calculated for BLAST and transition-transversion matrices? [04]
(c) Explain the terms: target identification and validation, lead molecule identification and optimization. [07]
OR
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Q.3
(a) Describe Hidden Markov Model. [03]
(b) Narrate the major features of PDB. [04]
(c) Give the importance of multiple sequence alignment. [07]
Q.4
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(a) Write the steps of Chau-Fasman method for secondary structure prediction. [03]
(b) What is DNA microarray? [04]
(c) Make a clear list of applications of Bioinformatics and briefly important of all. [07]
OR
Q.4
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(a) Make a list of all the tools for gene prediction. [03]
(b) Discuss maximum parsimony method representing phylogeny. [04]
(c) What are the major tools or techniques in proteomics? Explain any two of them. [07]
Q.5
(a) “Protein structure is related with its function”. Discuss briefly. [03]
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(b) Write the steps for GOR IV method. [04]
(c) What is Single nucleotide polymorphism? Explain. [07]
OR
Q.5
(a) Define: Progressive alignment. [03]
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(b) What is clinical trial? What are its phases? [04]
(c) Explain the types of proteomics studies, based on their characteristics. [07]
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