Subject Code: 2163601
GUJARAT TECHNOLOGICAL UNIVERSITY
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SEMESTER- VI(NEW) — EXAMINATION — SUMMER 2019
Subject Name: Medicinal Chemistry-I
Time: 10:30 AM TO 01:00 PM
Instructions:
- Attempt all questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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Q.1 (a) Write the mode of action (MOA) of Mono Amino Oxidase (MAO) inhibitor Antidepressant. Give one example with its structure. 03
(b) Write the MOA & Structural Activity Relationship (SAR) of Barbiturate class of Anticonvulsants. Illustrate with examples with structures wherever required. 04
(¢) Write the SAR of sympathomimetic drugs which contain a B-phenyl ethyl amine as parent structure. Illustrate with suitable examples. 07
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Q.2 (a) Write the biosynthesis of Adrenaline & Noradrenaline. 03
(b) Explain “Parkinsonism”. Write any two probable cause of this disease. Write the classification of Antiparkinsonism agents with suitable examples. 04
(¢) Explain Hyperlipidaemia. Write the classification of Antihyperlipidaemic agents with suitable examples. Write the MOA, metabolism & synthesis of any one Fibric acid derivative antihyperlipidaemic agent. 07
OR
(¢) What are the classification of Adrenergic drugs based on their structure. Write the synthesis of any one drug in each class. 07
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Q.3 (a) Write a note on with examples :~(1). Emetics, (2). Antiemetics, (3). Cardiovascular drugs. 03
(b) Describe the following drugs-with one synthesis: (1). Inhalation anaesthetics, (2). Intravenous anaesthetics 04
(¢) Write the MOA of Tricyclic antidepressant. Write the synthesis of Imipramine. (Structure given). 07
OR
Q.3 (a) Define Osteoporosis. Write a note on risk factors in female gender. Give two examples of Ant Osteoporotic drugs. 03
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(b) Describe basal anaesthetic, its advantages. Give synthesis of any one drug. 04
(¢) Write a note on Renin-Angiotensin Pathway. Write the synthesis of (1). Hydralazine HCI1 & (2). Methyl Dopa. 07
Q4 (a) Write a note on with suitable examples: (1). Sedatives & Hypnotics, (2). Cardiac Glycosides. 03
(b) Write the MOA & metabolism of any one Antiparkinsonism agent. 04
(¢) Describe the regulation of Catecholamines with appropriate structures. 07
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Date: 18/05/2019
Total Marks: 70
OR
Q4 (a) Write one example & MOA of antiepileptic drugs: (1) GABA analogue, (2). Benzodiazepine derivative. 03
(b) Write the SAR of Phenothiazine derivative Tranquilizer. 04
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(¢) Write the synthesis of Acetylcholine. Write the SAR of Cholinergic drugs. 07
Q.5 (a) What is an antiarrhythmic drug? Write its classifications with one example in each classification. 03
(b) Write the MOA of antipsychotic drugs: (1). Meprobamate, (2). Chlorpramazine 04
(¢) Write the MOA & SAR of benzodiazepine class of sedatives & hypnotics. 07
OR
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Q.5 (a) Describe with example: (1) Selective Serotonin receptor inhibitor antidepressant, (2). Selective Norepinephrine receptor inhibitor antidepressant. 03
(b) Write the MOA & metabolism of any one HMG-CoA reductase inhibitor Anticholesterol drug. 04
(¢) Write the SAR & MOA of barbiturate class of sedatives & hypnotics 07
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