Download GTU BE/B.Tech 2018 Winter 6th Sem New 2160401 Advanced Molecular Biology Ii Question Paper

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Subject Code: 2160401

GUJARAT TECHNOLOGICAL UNIVERSITY

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Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

1. What is significance of RNA splicing? (03)

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2. Explain base substitution mutation with suitable illustration. (04)

3. What are transposable elements? Explain its basic structure. (07)

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4. Define the terms reversion and suppression of mutation. (03)

5. Write a short note on base analogue mutagens. (04)

6. Explain positive regulation of lac operon (07)

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   OR

   Explain negative regulation of lac operon. (07)

7. What is significance of gene mapping? (03)

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8. Explain regulation of replication at genomic level in eukaryotes (04)

9. Explain mismatch repair mechanism in detail. (07)

   OR

   Explain primer walking. (03)

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10. Explain any one mechanism of regulation of metabolic pathway. (04)

11. Explain intragenic suppression mechanism. (07)

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12. What are post transcriptional controls? (03)

13. Explain attenuation mechanism. (04)

14. Explain lifecycle of T4 phage. (07)

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    OR

    What is alternative and trans-splicing? (03)

15. Write a note on splicing errors. (04)

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16. Explain splicing mechanism of nuclear mRNA. (07)

17. What is lysogeny? Give example of any one virus which performs lysogeny. (04)

18. What are integrons and retrotransposons? (07)

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19. Explain the technique of DNA fingerprinting. (03)

    OR

    Explain molecular basis of mutation. (04)

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20. Draw structure of retrovirus. (07)

21. Explain short gun DNA sequencing approach. (07)

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