Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase - II (CBME) Degree Examination - 04-Mar-2022
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Time: Three Hours Max. Marks: 100 Marks
PHARMACOLOGY - PAPER II (RS-4)
Q.P. CODE: 1029
(QP contains two pages)
Your answers should be specific to the questions asked
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Draw neat, labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks
- Classify Anti-tubercular drugs. Explain the mechanism of action and adverse effects of any one first line antitubercular drug. Mention Two drugs useful in treating Multi-drug resistant Tuberculosis.
- A 58 year old patient visits his general practitioner for routine health screening. His Fasting blood sugar was 140mg/dl, Post prandial blood sugar was 220mg/dl, HbA1c was 8%. A diagnosis of Type-2 Diabetes Mellitus was made.
- Classify Oral Antidiabetic drugs available to treat Type-2 Diabetes Mellitus
- Describe the mechanism of action and adverse effects of any one drug
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SHORT ESSAYS 8 x 5 = 40 Marks
- Mechanism of action, Uses and Adverse effects of Loop Diuretics
- Enumerate the Adverse effects of Glucocorticoids
- Therapeutic uses and adverse effects of Methotrexate
- Therapeutic uses and adverse effects of Metronidazole
- Mechanism of action, Uses and Adverse effects of Organic Nitrates
- Indications and adverse effects of Oral Iron preparations
- A 25 year old lady presents with symptoms of anxiety, tremors, weight loss, protrusion of eyes and palpitations. A diagnosis of Grave's disease was made. She was prescribed Propylthiouracil. Write the mechanism of action, adverse effects and uses of the Propylthiouracil.
- A 50 year old man visits his general practitioner for routine health screening. His blood pressure was 150/90 mm of Hg. He has no other co-morbidities. He was prescribed Ramipril. Explain the mechanism of action of Ramipril in this patient? Enumerate the advantages and adverse effects of Ramipril.
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SHORT ANSWERS 10 x 3 = 30 Marks
- Rationale of using Atorvastatin in primary hyperlipidemia
- Aldosterone antagonists are beneficial in Heart failure. Give reasons
- Mention three advantages of combined use of antimicrobial agents
- Mention Three drugs used in Chloroquine resistant Plasmodium falciparum malaria
- Rationale of combining Imipenem and Cilastatin
- Mention three advantages of Doxycycline over Oxytetracycline.
- Mention three drugs used in Scabies
- Metronidazole is not effective in aerobic infections- Explain
- Mention three advantages of Amikacin.
- Write three non-cardiac uses of Calcium channel blockers
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10 x 1 = 10 Marks
Multiple Choice Questions
- Which of the following drugs is a Potassium channel opener?
- Nicorandil
- Nifedipine
- Nitroglycerine
- Sodium Nitroprusside
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- Persistent dry cough is a side effect of which of the following antihypertensive drugs
- Captopril
- Atenolol
- Prazosin
- Methyldopa
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- Diuretics useful in treating Diabetes Insipidus are
- Loop diuretics
- Aldosterone antagonists
- Carbonic anhydrase inhibitors
- Thiazide diuretics
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- Route of administration of Iron sucrose is
- Intramuscular
- Intravenous
- Intradermal
- Subcutaneous
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- Radioactive iodine is the treatment of choice for the following category of Hyperthyroid patients
- Children
- Adults less than 25 years of age
- Elderly patients with coronary artery disease
- Pregnant women
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- Which of the following is a long acting Insulin?
- Insulin Glargine
- Insulin Aspart
- Insulin Lispro
- Insulin Glulisine
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- A child presented with excessive thirst, excessive urination and vomiting. Based on the investigations, pediatrician diagnosed it as Fanconi syndrome. A history of consuming an expired antibiotic agent was obtained from the mother. Which antibiotic is responsible for this syndrome
- Tetracycline
- Chloramphenicol
- Ampicillin
- Cephalexin
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- A 25 year old man on short course chemotherapy for Pulmonary Tuberculosis returns after a month with complaints of difficulty in reading and colour differentiation. Which of the following drug is responsible for his visual impairment?
- Rifampicin
- Pyrazinamide
- Ethambutol
- Streptomycin
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- The drug that is NOT effective in amoebiasis is
- Ornidazole
- Albendazole
- Satranidazole
- Secnidazole
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- Recombinant human granulocyte macrophage colony stimulating factor (GM-CSF) is used during cancer chemotherapy for the following purpose
- To increase the anti-tumour activity of the drug
- To prevent allergic reactions to the drug
- To hasten recovery from drug induced myelosuppression
- To prevent Vomiting
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