Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase – II (CBME) Degree Examination - <<>>
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Time: Three Hours Max. Marks: 100 Marks
PHARMACOLOGY – PAPER II (RS-4)
Q.P. CODE: 1029
(QP contains two pages)
Your answers should be specific to the questions asked
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Draw neat, labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks
- A 50-year-old woman visited the general practitioner for annual health screening. Her Blood pressure was 152/90 mm of Hg. She is diagnosed to be suffering from hypertension and is prescribed Angiotensin converting enzyme Inhibitors (ACE inhibitors). Explain the Mechanism of action, therapeutic uses, adverse effects, contraindications of ACE inhibitors
- Classify Anti-retroviral drugs with suitable examples. Explain the mechanism of action, uses and adverse effects of Zidovudine
SHORT ESSAYS 8 x 5 = 40 Marks
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- Mechanism of action, Uses and Adverse effects of Organic Nitrates
- Mechanism of action, Uses and Adverse effects of Thiazide diuretics
- Mechanism of action, Uses and Adverse effects of Clomiphene Citrate -
- Therapeutic uses and adverse effects of Glucocorticoids
- Drug treatment of Thyrotoxic crisis
- Antibiotics in cancer chemotherapy
- A 16 year old presents with complaints of weight loss and polyuria. His HbA1C was 9gm%. His fasting blood sugar was 178mg/dl and postprandial blood glucose was 240mg/dl. He was diagnosed as Type 1 Diabetes mellitus.
- Classify the insulin preparations based on their duration of action.
- What are the advantages of rapid acting insulins?
- A 38 year old patient presents with cough, fever and sputum since 4 days. A diagnosis of community acquired pneumonia was made and prescribed Levofloxacin.
- Explain the mechanism of action of Levofloxacin.
- Enumerate the adverse effects of Levofloxacin.
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SHORT ANSWERS 10 x 3 = 30 Marks
- Mention three advantages of Low molecular weight heparins
- Mention three uses of Tranexamic acid?
- Rationale of using Spironolactone in Heart failure
- Rationale of combining Sulfadoxine with Pyrimethamine
- Mention three drugs effective against Methicillin Resistant Staphylococcus Aureus (MRSA) infections
- Write three general properties of Aminoglycosides
- Write one drug regimen for multibacillary leprosy. Why drug combinations are used to treat leprosy?
- Mention any three groups of drugs used in the treatment for HIV infection Fungal
- Name three antiseptics
- Rationale of combining Ceftazidime with Tazobactum
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Multiple Choice Questions 10 x 1 = 10 Marks
- Drug which prolongs survival in heart failure patient is
- Digoxin
- Furosemide
- Enalapril
- Amrinone
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- Angiotensin receptor blockers are used in all the following conditions, EXCEPT
- Diabetic Nephropathy
- Heart failure
- Myocardial infection
- Pregnancy induced hypertension
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- Thiazide diuretics and furosemide have opposite effect on the excretion of
- Uric acid
- Calcium
- Magnesium
- Bicarbonate
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- Absorption of oral iron preparations can be facilitated by co-administering
- Vitamin K
- Vitamin E
- Vitamin A
- Vitamin C
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- Gynaecomastia is induced by all the following EXCEPT
- Digoxin
- Cimetidine
- Bromocriptine
- Ketoconazole
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- The route of administration of Insulin is
- Intradermal
- Subcutaneous
- Intramuscular
- Oral
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- The antimicrobial agent which acts by interfering with DNA function in the bacteria
- Amoxicillin
- Ciprofloxacin
- Streptomycin
- Erythromycin
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- Topical Sulfonamide used for chemo-prophylaxis in cases of burns is
- Sulfasalazine
- Silver sulfadiazine
- Sulfadoxine
- Sulfamethoxazole
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- Drug used for radical cure of Vivax Malaria is
- Chloroquine
- Quinine
- Primaquine
- Mefloquine
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- Antitubercular drug "Sterilizing" activity is
- INH
- Ethambutol
- Streptomycin
- Rifampicin
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