PAPER-II
Time: 3 Hours Maximum Marks: 100
Note:
- The candidates must limit their answers to the answer book (30 Pages) issued to them. No supplementary/Continuation answer sheet shall be provided
- Attempt all questions sequentially.
- Attempt Part-A & Part-B in separate answer books and Part-C in OMR sheet.
- Illustrate your answers with suitable diagrams, graphs and flow charts.
- OMR sheets shall be collected 20 minutes after starting of examination.
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SECTION- A Total Marks-40
Q1. Enlist various biochemical investigations for the assessment of following organ functions: 4+3+3=10 Marks
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- Liver functions
- Kidney functions
- Cardiac functions
Q2. Explain Briefly: 4x5=20 Marks
- Calcium homeostasis
- Role of kidney in the regulation of acid base balance.
- Transport of CO2 by hemoglobin
- Thin layer chromatography
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Q3. Write short note on the followings: 5x2=10 Marks
- Physiological functions of dietary fiber.
- Biochemical Role of Zn
- Principle of ELISA
- Principle of Electrophoresis.
- Tumor Markers in diagnosis and treatment
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SECTION- B Total Marks-40
Q1. Explain the role of oxidative stress in the pathogenesis of atherosclerosis and diabetes complications. 10 Marks
Q2. Write note on the followings: 4x5=20 Marks
- Universal cloverleaf model of tRNA
- Role of T-helper cells in immune responses
- Chemoprevention in cancer
- Functions of extracellular matrix
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Q3. Write short note on the followings: 5x2 =10 Marks
- RFLP
- Replication fork formation
- Codon-anticodon pairing
- Charging of tRNA with specific amino acids
- PCR applications
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SECTION-C 20x1=20 Marks
Q-1: Which of the following is the first sign of iron deficiency?
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Q-2:
- Transferrin saturation is low
- Serum ferritin is low
- Erythrocyte protoporphyrin increases
- Fall of Hb below normal
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Endemic Keshan disease (in eastern China) and Kaschin-Beck disease (eastern Asia) are caused due to deficiency of which of the followings?
- Selenium
- Cobalt
- Fluoride
- Iodine
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Q-3: Which of the following does not contain sulphur?
- Cell membrane
- Nucleic acids
- Enzymes
- Coenzymes
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Q-4: Which of the following is conjugated protein?
- Zein
- Albumin
- Peptone
- Hemoglobin
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Q-5: Cholesterol is which of the following
- Glycolipid
- Phospholipid
- Fatty acid
- Steroid
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Q-10: Shine-Dalgarno sequence is present in which of the RNA?
- tRNA
- mRNA
- rRNA
- snRNA
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Q-6: Which of the following form is naturally found in RNA double stranded molecules and RNA- DNA hybrid molecules?
- A-form
- B-form
- C-form
- Z-form
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Q-7: A person with extra 21 chromosome is called
- Turner's syndrome
- Down's syndrome
- Edward's syndrome
- Patau syndrome
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Q-8: Thymidine or pyrimidines dimers are induced by which of the following mutagen?
- Non-ionizing UV radiations
- Ionizing UV radiations
- Alkylating agents
- Base analogues
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Q-9: Which of the following disease is caused due defect in recombination repair system?
- Xeroderma pigmentosum
- Fanconi's anaemia
- Bloom's Syndrome
- Cockayne's syndrome
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Q-11: The termination of protein synthesis is catalyzed by
- Special type of tRNA that bind at termination codon
- A special type of protein released factor that binds at termination codon
- By the activity of ribosome itself
- By the activity of trailer region of mRNA
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Q-12: Transportation of proteins into which of the following cell organelles requires a carrier protein?
- Endoplasmic reticulum
- Mitochondria
- Peroxisome
- Chloroplast
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Q-13: Which of the following is not a conjugating agent in phase II of detoxification?
- Glucuronic acid
- Glycine
- Glutamic acid
- Glutathione
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Q-14: Which of the following play role in oxidation of xenobiotics?
- Cytochrome P660
- Cytochrome P450
- Cytochrome P448
- Both Cytochrome P450 and Cytochrome P448
- None of the above
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Q-19: In an acidic environment, O2 dissociates more readily from hemoglobin is called ?
- Haldane effect
- Bohr effect
- Hemburger phenomenon
- None of the above
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Q-15: Which of the following mechanisms does not control GFR?
- Renal autoregulation
- Neural regulation
- Hormonal regulation
- Chemical regulation of ions
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Q-16: Which of the following is not reabsorbed by renal tubules?
- Urea
- Bicarbonate ions
- Hydrogen ions
- Phosphate ions
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Q-17: Which of the following is not secreted into the urine via tubular secretion?
- Bicarbonate ions
- Hydrogen ions
- Ammonium ions
- Urea
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Q-20: Diphtheria toxin inhibits translation by binding with which of the following
- eIF-2
- eEF-2
- 40S subunit of ribosome
- 60S subunit of ribosome
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Q-18: The patients of sickle -cell anemia are resistant to
- Malaria
- Filaria
- Dengue
- Trypanosomiasis
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