SA-1565
Second Year M. B. B. S. Examination
February / March - 2011
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Pharmacology : Paper - I
Time : Hours] [Total Marks :
Instructions :
| Fill up the following details of ® signs on your answer book. Name of the Examination : --- Content provided by FirstRanker.com --- SECOND YEAR M. B. B. S. Name of the Subject : PHARMACOLOGY : PAPER – 1 Subject Code No. : | Seat. No. : --- Content provided by FirstRanker.com --- |
- Write to the point.
- Draw diagram if needed.
- Give example if needed.
- Answer briefly :
- By definition, Partial agonists have _______ efficacy than _______ agonists. (fill in the blank)
- When we can say that spare receptor do exist ?
- Mention two uses of placebo.
- Iron is contraindicated in _______ type of anemia. (Fill in the blank)
- A patient on _______ should avoid cheese in his diet for fear of _______ (fill in the blank)
- Mention two contraindications of nasal decongestants which are alpha agonistic in nature.
- Why ipratropium and not atropine is preferred for COPD patient ?
- Name the acute reaction seen with metoclopramide. How it is managed ?
- What is "double blind" in a protocol of clinical trial of a drug ?
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SA 1565]
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[ Contd...
2 Write any three :
- Enumerate various therapeutic uses of botulinium toxin. Discuss how it brings benefits for these conditions.
- Give your comments regarding rationality and limitations on "cough mixtures".
- Enlist various drugs for angina pectoris. Discuss briefly how nitrates bring benefits for such patient. (Exclude molecular mechanism in your answer).
- Discuss with suitable examples the concept of competitive and noncompetitive antagonism of drug.
- Describe with suitable examples the concept of up and down regulation of receptor.
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3 Answer any three :
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- Explain with suitable examples how OTC drugs can be hazardous in therapeutics.
- What is home made ORS ? Describe it's advantages.
- Enlist various drugs from different categories for peptic ulcer. Describe briefly the drug therapy of non-healing peptic ulcer.
- What is "thalidomide tragedy" ? What lesson the world had learnt from that ?
- Enlist various anticoagulants. Discuss briefly the clinical uses and monitoring of anticoagulant therapy.
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4 Answer any two :
- Classify various anticholinergic drugs. Describe their therapeutic uses giving pharmacological basis.
- Discuss various requirements and limitations of clinical trials.
- Classify various antihypertensives. Discuss general principles of drug therapy of hypertension. (Your answer should include international society of hypertension (ISH) and JNC-7th report guidelines)
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10
SA-1565]
[ 400 ]
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