Download RUHS MBBS 1st year Biochemistry Paper I 2021 February Question Paper

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I-MBBS

(This paper consists of 2 pages)

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First M.B.B.S. (Main) Examination (New Scheme)

February - 2021

PHYSIOLOGY & BIOCHEMISTRY

Paper-I

Time: Three Hours

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Maximum Marks: 100

Attempt all questions in both sections

(Use separate answer book for each section)

Section-A

1. Fill in the blanks: 6 x 1 = 06
   1. Inherited disorder characterized by absence of peroxisomes in the cells is __________

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   2. Coenzyme required in Transamination reaction __________
   3. Polysaccharide used as a plasma substitute __________
   4. Abnormal accumulation of sphingomyelins in the liver, spleen and brain causes __________
   5. Purely Ketogenic amino acid __________
   6. Main storage form of Iron is __________

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2. Choose the correct option in the following multiple choice questions: 4 x 1 = 04
   1. Vitamin Niacin is synthesized from amino acid:
      1. Tyrosine
      2. Arginine
      3. Tryptophan
      4. Methionine

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   2. Example of high energy compound is:
      1. Glucose-1-Phosphate
      2. Glucose-6-Phosphate
      3. Fructose-6-Phosphate
      4. Acetyl CoA

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   3. Laboratory evaluation of acid-base imbalance involves estimation of:
      1. pH
      2. HCO3
      3. pCO2
      4. All

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   4. Porphyria inherited as Autosomal recessive disorder is:
      1. Congenital Erythropoietic Porphyria
      2. Erythropoietic Protoporphyria
      3. Porphyria Cutanea Tarda
      4. Variegate Porphyria

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3. A 6 month old boy was brought to Pediatrician with a history of very light colour hairs and eyes and looked much fairer than his parents and siblings. He was also delay in developmental milestones. Mother also gave a history of seizures, frequent skin infection and an unusual mousy odour to his skin, breath and urine. 5 x 3 = 15
   1. What is the probable diagnosis and suggest its cause.
   2. Why his skin and hair color is fair?
   3. Which test in blood and urine is to be performed?

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   4. Why there is delay in developmental milestones?
   5. What is the treatment?

4. Write short notes on (Any five): 5 x 2 = 10
   1. Enlist the substrates of Gluconeogenesis
   2. Ketosis

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   3. Calcitriol
   4. Lesch-Nyhan Syndrome
   5. Anion-Gap
   6. Transaminases

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5. Explain briefly (Any three): 3 x 5 = 15
   1. Kerbs Henseleit Cycle
   2. Catabolism of Purine and its disorders
   3. Functions of Vitamin C
   4. Chemiosmotic theory

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Section-B

6. Define lipoproteins with examples. Explain the metabolism of HDL cholesterol and its role in health and disease. 20
7. Explain Why (Any five): 5 x 2 = 10
   1. Neonates are more susceptible to develop Vitamin K deficiency.
   2. Eating maize causes pellagra like symptoms.
   3. Essential fatty acids helps in prevention of fatty liver.

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   4. Hyperuricemia is associated with Von-Gierke's disease.
   5. Direct bilirubin is increased in Obstructive Jaundice.
   6. HbA1c is a good indicator of sugar control in T2DM.
8. Explain briefly (Any four): 4 x 5 = 20
   1. Isoenzymes.

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   2. Laboratory diagnosis of diabetes mellitus.
   3. Maple syrup urine disease.
   4. Antioxidant vitamins.
   5. Functions of calcium

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