Download RUHS MBBS 2nd year Pathology Paper I 2022 January Question Paper

Section-A

1. Fill in the blanks: 6 x 1 = 06
   1. In Pyroptosis, cell death is due activation of ____________________
   2. Alkaptonuria is characterized by excretion of ____________________ in urine.
   3. An elongated alpha chain variant of HbH is termed as ____________________
   4. Most frequent paraprotein seen in about 50% cases of multiple myeloma is ____________________
   5. Hypergranular promyelocytes with multiple Auer Rods is a feature of ____________________

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   6. Shortened red cell survival is best tested by ____________________ labelling.
2. Answer the followings (Multiple Choice Questions): 4 x 1 = 04
   1. Caseous Necrosis is not found in-
      1. Tuberculosis
      2. Histoplasmosis
      3. Cytomegalovirus infection

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      4. Syphilis
   2. The ratio of CD4+ cells to CD8+ cells in circulation is-
      1. 1:1
      2. 3:1
      3. 2:1

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      4. 1:2
   3. Haemoglobin appears in Red blood cells at which stage of erythropoiesis-
      1. Early erythroblast
      2. Late erythroblast
      3. Intermediate erythroblast

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      4. Reticulocyte
   4. DIC is characterizes by all except-
      1. Thrombocytopenia
      2. Reduced fibrinogen
      3. Prolonged Prothrombin time

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      4. Absence of FDP's
3. A 30 year old male is admitted due to High grade fever from 6-7 days. The laboratory investigations reveal Total Leucocyte count of 75000/cumm with Neutrophils 96%, Haemoglobin-9.0 gm% and platelet count of 5.6 lacs/cumm. Neutrophils show toxic granulation and presence of immature cells. NAP score is also elevated.
   1. What is the probable diagnosis and why? 05

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4. b) Which other blood disorder has very high total leukocyte count with marked neutrophillia? 05
5. c) How will you differentiate these two conditions? 05
6. Write short notes on (Any five): 5 x 2 = 10
   1. Primary amyloidosis
   2. Gas gangrene

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   3. Caseous necrosis
   4. Erythropoietin
   5. Decompression sickness
   6. Hyaline change

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7. Explain briefly (Any three): 3 x 5 = 15
   1. Free radical cell injury
   2. Septic shock
   3. FAB classification of AML
   4. Diagnostic criteria for multiple myeloma

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Section-B

6. Classify bleeding disorders. Discuss their differential diagnosis with special reference to bleeding time, Prothrombin time, platelet count, fibrin degradation products, factor VIII and factor IX levels. 20
7. Write short notes on (Any five): 5 x 2 = 10
   1. Causes of splenomegaly
   2. Dysplasia
   3. Granuloma
   4. Fate of thrombus

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   5. Cryoprecipitate
   6. Reticulocyte count
8. Explain briefly (Any four): 4 x 5 = 20
   1. Tumour markers
   2. Schilling test

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   3. Causes of Pancytopenia
   4. Protein energy malnutrition
   5. Red cell indices