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Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination - May 2016
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[Time: 3 Hours] [Max. Marks: 100]
BIOPHARMACEUTICS AND PHARMACOKINETICS
(RS 2 & RS 3)
Q.P. CODE : 9283
Your answers should be specific to the questions asked.
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Draw neat labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Explain various factors affecting biotransformation of drugs.
- Define Rate of Elimination and Clearance. Explain Non-Renal Clearance in detail.
- Explain in detail the application of pharmacokinetics in development of controlled release drug delivery system.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Explain drug related factors affecting absorption of drug.
- Deduce equation to obtain pharmacokinetic parameters of a drug administered by IV infusion and body acting as single compartment.
- Explain significance of protein binding.
- Explain concept of loading dose and maintenance dose.
- Write a note on in-vitro in-vivo correlation.
- Why is human serum albumin considered a versatile protein for drug binding?
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SHORT NOTES 2 X 5 = 10 Marks
- Individualization
- Polar drugs such as penicillin normally do not cross BBB but do so in meningitis. Explain.
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