Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - MAY 2016
[Time: 3 Hours] [Max. Marks: 100]
Advanced Pharmacology and Toxicology
(Revised Scheme 4)
Q.P. CODE: 9349
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Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Explain the Pathophysiology and Pharmacotherapy of Hypertension.
- Classify receptors with suitable examples. Explain the structure and importance of G protein coupled receptor. Explain the role of secondary messengers of GPCR in cell signaling.
- Explain the pathophysiology and management of Parkinson’s and Alzheimer’s disease.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Explain the mechanism of action and therapeutic uses of antihistamines.
- Discuss the current trends in the Pharmacotherapy of osteoporosis.
- Explain the electrophysiology of myocardium and explain how class I antiarrhythmic drugs act.
- Explain the mechanism of action of drugs used in the treatment of AIDS.
- Explain any two methods employed for reproductive toxicity assessment.
- Explain the etiology of epilepsy, pharmacotherapy of epilepsy and adverse effects of antiepileptic drugs.
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SHORT NOTES 2 X 5 = 10 Marks
- Explain the objectives of treatment of Myasthenia gravis and ADRs associated with drugs used to treat it.
- What is Carcinogenicity? Explain the two in vivo methods in assessing carcinogenicity.
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