Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination - Nov 2011
[Time: 3 Hours] [Max. Marks: 100]
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BIOPHARMACEUTICS AND PHARMACOKINETICS
(RS 2 & RS 3)
Q.P. CODE: 9283
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
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LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- What is biotransformation and list out the factors affecting biotransformation? Give the classical examples for the phase I and phase II reactions
- Explain the factors influencing GI absorption of a drug from its dosage forms
- Discuss the one compartment pharmacokinetic model and write the application of pharmacokinetic in the design and development of new dosage forms
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
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- Explain active transport with illustration
- Discuss briefly bioequivalence studies
- Explain briefly Michaelis-Menten equation
- Hepatic clearance - explain
- Explain loading dose and maintenance dose
- List out the factors affecting protein binding
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SHORT NOTES 2 X 5 = 10 Marks
- Binding of drugs to lipoproteins
- Physiologic barriers to distribution of drugs
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