Download RGUHS M.Pharmacy First Year Nov 2016 9338 Biopharmaceutics And Pharmacokinetics Revised Scheme 4 Question Paper

First Rajiv Gandhi University of Health Sciences

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First Year M. Pharm Degree Examination - NOV 2016

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[Time: 3 Hours]

Biopharmaceutics and Pharmacokinetics

(Revised Scheme 4)

Q.P. CODE: 9338

Your answers should be specific to the questions asked.

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Draw neat, labeled diagrams wherever necessary.

[Max. Marks: 100]

LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks

1. Explain various methods to improve bioavailability of poorly water-soluble drugs.
2. Explain in detail non-per oral routes drug absorption.

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3. What are the assumptions of two compartmental model? Explain two compartmental open model with i.v bolus drug administration. Derive various pharmacokinetic parameters of the same.

SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks

4. Explain one compartment open model with extravascular drug administration along with various pharmacokinetic parameters.
5. Write about physiological Pharmacokinetic model. Comment on statistical moment theory.
6. Explain in detail about bioequivalence study.

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7. Write a note on Phase II Biotransformation reactions.
8. Describe Noyes-Whitney's equation. Comment on similarity and dissimilarity factors.
9. Dose adjustment in renal and hepatic impairment

SHORT NOTES 2 X 5 = 10 Marks

10. Kinetics of protein binding

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11. Non renal excretion of drugs

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