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Rajah Jandhi University of Health Sciences
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First Year M. Pharm Degree Examination - NOV 2016
[Time: 3 Hours] [Max. Marks: 100]
Pharmacological Screening Methods and Clinical Evaluation
(Revised Scheme 4)
Q.P. CODE: 9350
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Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Explain the principle and methods employed in preclinical evaluation of anti-arrhythmic and anti-atherosclerotic drugs.
- Explain the scope of Pharmacokinetic parameters in drug discovery process. (12+8 = 20)
- Explain the use of transgenic and genetically prone animals in preclinical screening. (10+10 = 20)
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- What is Schedule Y? Explain the salient feature and recent amendment for Schedule Y. (2+4+4 = 10)
- How ANDA master file is different from NDA, explain with a drug master file.
- Explain the screening of antidepressant drugs.
- Explain the principles of techniques involved in cell culture and its maintenance.
- Enumerate the various animal models available for screening of antiepileptic drugs and explain any two models in detail.
- Write about importance of Pharmacovigilance.
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SHORT NOTES 2 X 5 = 10 Marks
- Explain the principle and method involved in Dylorus technique.
- What is a lead compound? Enumerate the sources of lead compound.
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