Download RGUHS M.Pharmacy First Year 2010 Oct Pharmacological Screening Methods And Clinical Evaluation Paper Iii Revised Scheme 2 Question Paper

Rajiv Gandhi University of Health Sciences

First Year M.Pharm Degree Examination – October 2010

[Time: 3 Hours] [Max. Marks: 100]

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PHARMACOLOGICAL SCREENING METHODS AND CLINICAL EVALUATION

PAPER III

(Revised Scheme 2)

Q.P. CODE : 9243

Your answers should be specific to the questions asked.

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Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks

1. a) Define bioassay and explain principles of bioassays and add a note on biological variation.
   b) Discuss the bioassay of adrenaline.
2. a) Describe various methods used to screen Analgesic agents.
   

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   b) Describe any two models employed in the screening of anti anginal agents.
3. Explain the various phases of clinical trails and add a note on ICH-GCP guidelines.

SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks

4. List the screening techniques for nootropics. Explain any two models
5. ICMR guidelines

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6. Preparation of IND and NDA
7. Newer techniques of drug administration
8. General characteristics of laboratory Rats
9. In-vitro drug screening methods.

SHORT NOTES 2 X 5 = 10 Marks

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10. Informed concent
11. Nude mice and its importance

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