Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - May 2011
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[Time: 3 Hours] [Max. Marks: 100]
BIOPHARMACEUTICS AND PHARMACOKINETICS
(RS 2 & RS 3)
Q.P. CODE: 9283
Your answers should be specific to the questions asked.
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Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Explain the methods of determining absorption
- Explain michaelis - menten equation and estimation of Km and Vmax
- State the significance of using compartment models for pharmacokinetic studies
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Write briefly on Therapeutic drug monitoring
- Discuss on the dosage adjustment in renal impairment
- Describe bioequivalence and its importance
- Discuss on the factors affecting drug distribution
- Write briefly on conjugation reactions
- Write briefly on factors affecting protein binding
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SHORT NOTES 2 X 5 = 10 Marks
- Hepatic clearance
- Loading dose
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