First Year M. Pharm Degree Examination - Oct/Nov 2014
[Time: 3 Hours] [Max. Marks: 100]
Biopharmaceutics and Pharmacokinetics
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(Revised Scheme 4)
Q.P. CODE: 9338
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
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- Explain various approaches to improve dissolution of poorly water soluble drugs.
- Explain in detail about the absorption of drugs from non-per oral routes.
- Differentiate between compartmental model and physiological model. Explain one compartment open model with extravascular drug administration along with various pharmacokinetic parameters.
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Measurement of bioavailability
- Explain Phase II reactions with examples.
- Explain in detail about the concept of clearance along with equations.
- Explain kinetics of protein binding. Write its significance.
- Explain the importance of therapeutic drug monitoring in individualization of a drug therapy.
- Write the causes for non-linearity. Write about the method of detection.
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SHORT NOTES 2 X 5 = 10 Marks
- Application of pharmacokinetics in new drug development
- Accumulation index
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