Download RGUHS M.Pharmacy First Year 2015 November 9202 Advanced Organic Chemistry Rs 2 And Rs 3 Question Paper

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Rajiv Gandhi University of Health Sciences

First Year M.Pharm Degree Examination – NOVEMBER 2015

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[Time: 3 Hours] [Max. Marks: 100]

ADVANCED ORGANIC CHEMISTRY

(RS 2 & RS 3)

Q.P. CODE: 9202

Your answers should be specific to the questions asked.

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Draw neat labeled diagrams wherever necessary.

LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks

1. What are carbocations? Classify them with examples, write the reaction in which they are generated. Explain the stability of carbocations.
2. Give one synthesis and an example of a medicinal agent belonging to the following heterocyclic ring systems: a) Thiazoles b) Isoxazoles c) Benzimidazole d) Purine.
3. Discuss the nucleophilic aliphatic substitution reaction. Write SN1 and SN2 mechanisms, kinetics and stereochemistry.

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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks

4. Write the methods of synthesis and applications of acetoacetate esters.
5. What is a Grignard reagent? Write the mechanism of reaction involving a Grignard reagent and its synthetic applications.
6. Discuss the mechanism and synthetic applications of aldol condensation.
7. Write the synthetic route for Quinoline and Ququinazoline.

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8. Explain the stereochemistry of steroids.
9. Explain the oxidation-reduction reaction reagents used, mechanism and applications.

SHORT NOTES 2 X 5 = 10 Marks

10. Microwave irradiation techniques.
11. Hyperconjugation.

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