FirstRajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination - NOVEMBER 2015
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[Time: 3 Hours] [Max. Marks: 100]
ADVANCED PHARMACOLOGY AND TOXICOLOGY
PAPER II
(RS2 & RS3)
Q.P. CODE : 9242
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Explain the molecular level mechanisms of bacterial protein synthesis and drugs affecting it.
- Discuss the current developments of anti-microbial-drug-resistance.
- Describe the transport of lipoproteins in the body and the mechanisms of action of hypolipidaemic drugs.
- Explain the biosynthesis, physiological significance and pharmacological actions of arachidonic acid metabolites. What is the role of NSAIDs in inflammation?
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Discuss the molecular mechanisms of actions of beta-receptors.
- Write a detailed account of the mediators of immune system and explain how drugs modify their effect?
- With a brief description of thyroid function, explain the mechanisms of action of antithyroid drugs.
- Discuss the mechanism of action of oral antidiabetic drugs.
- Explain the molecular mechanism of action of opioids. Describe the pharmacological actions of morphine on the CNS.
- Describe the cholinergic transmission and drugs affecting it. Add a note on the sites of release of Ach in ANS.
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SHORT NOTES 2 X 5 = 10 Marks
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- Management of toxicity reaction in human
- Dose response relationship
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