Download RGUHS M.Pharmacy First Year 2015 November 9243 Pharmacological Screening Methods And Clinical Evaluation Paper Iii Rs 2 And Rs 3 Question Paper

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9243_9999_9_S272.doc

Rajiv Gandhi University of Health Sciences

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First Year M. Pharm Degree Examination – NOVEMBER 2015

[Time: 3 Hours] [Max. Marks: 100]

PHARMACOLOGICAL SCREENING METHODS AND CLINICAL EVALUATION

PAPER III

(RS 2 & RS 3)

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Q.P. CODE: 9243

Your answers should be specific to the questions asked.

Draw neat labeled diagrams wherever necessary. Answer all questions

LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks

1. a) Explain various mechanisms of drug transport across cell barrier with neat diagrams
   

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   b) Define receptor. Classify and discuss various types of receptors with neat diagrams
2. a) What is bioassay? Explain the bioassay of Insulin
   b) Define transgenic animals. Discuss the importance of transgenic animals in drug screening
3. a) Discuss the various phases of clinical trials
   b) Discuss the rational drug use

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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks

4. Null hypothesis and coefficient of variation
5. Variability in drug action due to age, sex and weight
6. Wilcoxon test and their application in drug
7. Screening of antimalarial agents

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8. Applications of cell lines in drug screening
9. Phase I and phase II drug metabolism

SHORT NOTES 2 X 5 = 10 Marks

10. Bioequivalence
11. ICMR guidelines

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