First Rajah Gandhi University of Health Sciences
First Year M.Pharm Degree Examination - NOVEMBER 2015
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[Time: 3 Hours]
BIOPHARMACEUTICS AND PHARMACOKINETICS
(RS 2 & RS 3)
Q.P. CODE : 9283
Your answers should be specific to the questions asked.
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Draw neat labeled diagrams wherever necessary.
[Max. Marks: 100]
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Explain how bioavailability can be determined from oral administration of solid dosage forms.
- Discuss the application of pharmacokinetics in dosage form design.
- Discuss the various in-vitro dissolution testing methods used in pharmaceutical product evaluation.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Illustrate the procedure for adjusting the dosage regimen of patients with renal impairment.
- Give the schematic representations of various pharmacokinetic models.
- Explain Michaelis-Menten equation.
- Discuss the various drug excretion pathways.
- Explain the various factors that influence drug metabolism.
- Discuss the kinetics of drug-protein binding.
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SHORT NOTES 2 X 5 = 10 Marks
- Mention the importance of bioequivalence studies.
- Mention the significance of drug protein binding in drug therapy.
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