Rajah Sirandhi University of Health Sciences
First Year M. Pharm Degree Examination - NOVEMBER 2015
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[Time: 3 Hours]
Biopharmaceutics and Pharmacokinetics
(Revised Scheme 4)
Q.P. CODE: 9338
Your answers should be specific to the questions asked.
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Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Explain in detail about physicochemical properties of drug absorption.
- What is pharmacokinetic model? Explain one compartment open model in detail with i.v bolus drug administration. Derive various pharmacokinetic parameters of the same.
- Explain multiple dosing with respect to i.v and oral route in detail.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Determination of rate of absorption by Wagner-Nelson Method
- In vitro, in vivo correlation
- Explain various causes of non-linearity reaction. With the help of equation, estimate Km and Vmax using Michaelis-Menten equation.
- What are the various factors affecting rate of distribution?
- Physiological pharmacokinetic model
- Phase I reactions
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SHORT NOTES 2 X 5 = 10 Marks
- MRT for various compartmental model
- Therapeutic drug monitoring
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