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Rajiv Gandhi University of Health Sciences, Karnataka
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III Year Pharm-D Degree Examination – NOV 2017
MEDICINAL CHEMISTRY (RS & RS2)
Q.P. CODE: 2865
Time: Three Hours
Max. Marks: 70 Marks
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Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS (answer any two) 2 x 10 = 20 Marks
- a) Write short notes on penicillinase resistant oral penicillins. b) Give an account of chemistry and stability of penicillin molecule
- Classify cardiovascular agents with examples. Write an account on calcium channel blockers. Give the synthesis of Diltiazem
- a) Add a note on folate reductase inhibitors. Explain the synergistic action of sulphamethoxazole and trimethoprim. b) Discuss the MOA of Mercaptopurine and Busulfan.
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SHORT ESSAYS (answer any six) 6 x 5 = 30 Marks
- Classify anthelmintics with examples. Give the synthesis of Albendazole
- Classify antiameobic agents with examples. Give the synthesis of Metronidazole
- Explain the SAR of sulfonamides? Give the synthesis of Dapsone
- Describe in detail the status of natural products useful in the treatment of human malarial infections
- Discuss the MOA of alkylating agents. Write the synthesis of Cyclophosphamide
- Give three chemical structures and uses of drugs belonging to antihyperlipidemic agents
- Name any four antiviral agents. Give the structure and uses of Amantadine.
- Classify antitubercular agents. Write the structure of any two antitubercular drugs.
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SHORT ANSWERS 10 x 2 = 20 Marks
- What are lead molecules? How are they useful in drug discovery?
- Define combinatorial chemistry. Enlist its applications
- Write the structure and uses of alpha- agonist
- Name any four drugs used in the treatment of type-2 diabetes
- Give the MOA of Anagliptin
- Write any two structures of Imidazole derivatives used as antithyroids
- Give the MOA of mercurials
- Structure and uses of Acetazolamide
- Name any two drugs used for examination of angiography and urography
- What are steroids? Name any one drug containing pregnane nuclei
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