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Rajiv Gandhi University of Health Sciences, Karnataka
III Year Pharm-D Degree Examination – NOV 2016
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Time: Three Hours
Max. Marks: 70 Marks
MEDICINAL CHEMISTRY
Q.P. CODE: 2865
Your answers should be specific to the questions asked
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Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- What are Sulfonamides? Classify sulfonamides and give one example of drug with structure under each class. Give the mechanism of action of Sulphonamides.
- Give the synthesis, mechanism of action and uses of (a) Chloroquine (b) Propranolol.
- Discuss prodrugs in detail with examples. Add a brief note on computer aided drug design.
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Classify anti-arrhythmic agents with examples. Write the mechanism of action and therapeutic uses of Procainamide.
- Add a note on SAR of 4-Amino quinolines.
- Give three chemical structures and uses of drugs belonging to antihyperlipidemic agents.
- Explain how anti-metabolites act as anti-neoplastic agents with suitable examples.
- Classify diuretics with examples. Outline the synthesis of Acetazolamide.
- Write the chemistry, mode of action and therapeutic uses of ß-lactamase inhibitors.
- Classify local anti-infective agents with examples. Outline the synthesis of Hexylresorcinol.
- Write the chemistry and mechanism of action of Azole anti-fungal agents.
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SHORT ANSWERS 10 x 2 = 20 Marks
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- Give two examples and uses of Anthelmintics.
- Write the synthesis of Isoniazid.
- Define anticoagulants with examples.
- Give two examples and uses of anti-protozoal drugs.
- Give the chemical structure and uses of Ethambutol.
- Applications of QSAR.
- What are urinary tract anti-infectives and give examples.
- What are anti-anginal drugs and give examples.
- Write the structure and uses of any one cephalosporin's.
- Name the heterocyclic nucleus present in Nifedipine and Pamaquine.
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