Download RGUHS Pharm-D 4th Semester 2016 Nov-Dec 2871 Biopharmaceutics And Pharmacokinetics Question Paper

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Rajiv Gandhi University of Health Sciences, Karnataka

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IV Year Pharm-D / I Year Pharm-D (Post Baccalaureate) Degree Examination – NOV 2016

Time: Three Hours

Max. Marks: 70 Marks

BIOPHARMACEUTICS AND PHARMACOKINETICS

Q.P. CODE: 2871

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Your answers should be specific to the questions asked

Draw neat, labeled diagrams wherever necessary

LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks

1. Define absorption. What are the various physicochemical factors affecting rate of absorption?
2. What is compartment modeling? State the assumptions of Two Compartment Model and explain Two Compartment Model with administration through i.v infusion.

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3. What are non-linear pharmacokinetics? Discuss the various factors causing non-linearity.

SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks

1. What is gastric emptying? Discuss the factors affecting gastric emptying of drugs.
2. Explain Statistical Moment theory.
3. Explain the influence of pharmaceutical ingredients on drug absorption.

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4. What is renal clearance? Discuss any three factors affecting renal clearance.
5. Loading and maintenance dose
6. Discuss various methods to improve bioavailability of Class II drugs.
7. What is protein binding? Discuss the significance of protein binding with examples.
8. Influence of physiological barriers in drug distribution

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SHORT ANSWERS 10 x 2 = 20 Marks

1. Fick's first law of diffusion
2. Buffered Aspirin tablets are more suitable than sodium salt forms of the drug. Why?
3. Unlike glomerular filtration, active secretion of drug is unaffected by protein binding. Give reasons.
4. Define Pharmacokinetics. Mention its application in drug discovery.

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5. Calculate the amount of drug in the body when the plasma concentration is 10ng/ml and volume of distribution of drug is 300lts.
6. Absorption window - mention its significance.
7. Demerits of Wagner Nelson method in calculating Ka
8. Define Pharmaceutical and biological equivalence.
9. What is Zero Order reaction? Give example.

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10. What is AUC? Give the equation to calculate AUC₀⁸.

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