Rajiv Gandhi University of Health Sciences, Karnataka
III Year Pharm-D Degree Examination – NOVEMBER 2015
Time: Three Hours
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Max. Marks: 70 Marks
MEDICINAL CHEMISTRY
Q.P. CODE: 2865
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
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LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- Discuss the SAR and mode of action of Urinary Tract anti-infective Quinolones. Outline the synthesis of Ciprofloxacin.
- What are Antihypertensive agents? Classify them with examples. Outline the synthesis of Propranolol.
- Define the term 'antibiotic'. Discuss the chemical degradation of Penicillin. Outline the synthesis of Chloramphenicol.
SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
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- Outline the synthesis and mode of action of any one ß-blocker.
- What are antifungal antibiotics? Write the structure of any two compounds.
- Write a note on 'CADD'.
- What are Carbonic Anhydrase Inhibitors? Discuss their mode of action.
- Discuss the SAR of Sulphonamides. Add a note a note on their mode of action.
- What are anti- Arrhythmic agents? Outline the synthesis of Procainamide.
- Outline the synthesis and uses of Pamaquine and Pyrimethamine.
- Discuss mode of action of anti hyperlipidemic agents with examples.
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SHORT ANSWERS 10 x 2 = 20 Marks
- Write the structures of Diethyl Carbamazine and Mebendazole.
- What are Macrolides? Write the structure of any one compound.
- Write the structure and chemical name of Lomustine.
- Outline the synthesis of PAS.
- Write the structures and chemical names of any 4-Aminoquinoline anti-malarials.
- Outline the synthesis of Warfarin.
- Write the structure and uses of Zidovudine.
- Discuss the concept 'Combinatorial Chemistry'.
- Name any two Aminoglycoside antibiotics. Write the structure of any one.
- What are anti-anginal agents? Write the structure of any one compound.
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