Rajiv Gandhi University of Health Sciences, Karnataka
IV Year Pharm-D / I Year Pharm-D (Post Baccalaureate) Degree Examination
NOVEMBER 2015
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Time: Three Hours
Max. Marks: 70 Marks
BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. CODE: 2871
Your answers should be specific to the questions asked
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Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
- Explain the concept of compartment model. Discuss one compartment model with reference to I.V infusion.
- Discuss minimum two factors from each group that influence drug absorption.
- Write multi compartment models for I.V bolus administration.
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SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
- Comparison between I.V, oral, I.M routes of administration with special reference to plasma drug concentration profile
- How do you estimate Ka by Wagner Nelson method?
- Draw typical blood level curve and discuss the factors influencing blood levels following oral administration.
- Limitations of one compartment model
- Determination of oral bioavailability by AUC method
- Brief introduction about non-linear pharmacokinetics
- What are the factors affecting distribution of drugs.
- Give a protocol for a bioavailability study.
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SHORT ANSWERS 10 x 2 = 20 Marks
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- What is facilitated transport?
- Define volume of distribution.
- Biological half-life and its significance
- Effect of particle size on drug dissolution
- Define pharmacokinetics.
- Define loading & maintenance dose.
- Significance of bioequivalence studies
- Represent a two-compartment model diagrammatically.
- Minimum effective level and maximum safety level
- Define non-competitive inhibition.
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