Download RGUHS Pharm-D 1st Semester 2015 Dec 2877 Pharmaceutical Organic Chemistry Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Pharm.D (Doctor of Pharmacy) 1st Semester 2015 Dec 2877 Pharmaceutical Organic Chemistry Question Paper.

Rajiv Gandhi University of Health Sciences, Karnataka
I Year Pharm-D Degree Examination ? NOVEMBER 2015
Time: Three Hours Max. Marks: 70 Marks
PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. CODE: 2877
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
1. Define and give the mechanism of: (a) Cannizzaro reaction (b) Aldol condensation.
2. State the Anti-Markovnikov?s rule. Write the mechanism of addition of HBr to propene in the
absence and presence of peroxide.
3. Write the mechanism of Friedel Craft?s alkylation and acylation with their limitations.

SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
4. Write the structure and medicinal uses of Benzyl benzoate, Saccharin sodium.
5. Define and classify isomerism with suitable examples.
6. Discuss about SN
1
mechanism and stereochemistry.
7. Write the effect of temperature in 1,2-addition and 1,4 addition.
8. Discuss Friedel Craft?s acylation with mechanism.
9. Explain the mechanism of dehydration of Alcohols.
10. What is Bayer?s strain theory and explain with examples.
11. Give the mechanism of Benzoin condensation.

SHORT ANSWERS 10 x 2 = 20 Marks
12. Outline the conversion of carboxylic acid to ester.
13. Define keto-enol Isomerism with examples.
14. Define Nucleophiles with examples.
15. Name the following compounds:
CH
3

?
(a) CH
3
-CH
2
-CH
2
-COOH (b) CH
3
-C-CH
3

?

CH
3

16. State the Lowry Bronsted theory of Acids and Bases.
17. Which is more stable trans-2-butane or cis-2-butane? Why?
18. What is Homolysis and Heterolysis?
19. Comment phenol is Acidic but not ethanol.
20. Define hyper conjugation.
21. Outline the conversion of Aniline to Benzoic Acid.
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