Rajiv Gandhi University of Health Sciences, Karnataka
I Year Pharma-D Examination – Jan 2014
Time: Three Hours
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Max. Marks: 70 Marks
PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. CODE: 2854
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
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LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- a) Discuss the SN1 reactions with reference to i) Mechanism ii) Stereo chemistry iii) Rearrangements b) Write mechanism involved in E1 and E2 reaction.
- Explain the following with mechanism: (a) Cannizzaro's reaction (b) Perkin's condensation (c) Benzoin condensation.
- a) Explain the concept of electron release via resonance with an example. b) Explain the mechanism of Friedel Craft's alkylation and sulphonation.
SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
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- Define free radicals. Give the mechanism for free radical chain reactions of alkanes.
- Write notes on: a) intermolecular forces b) Hydrogen bonding and its effect on solubility.
- Explain 1, 2 and 1,4-electrophilic addition in conjugated dienes.
- What are alkenes? Give the rules for the nomenclature of alkenes with examples.
- Explain:a) Preoxide effect with mechanism b) Addition of carbenes to alkenes
- Give the preparation and uses of Glyceryl trinitrate and Aspirin.
- What are carbocations? Discuss their classification and stability.
- Explain the effect of substituents on the acidity of carboxylic acids.
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SHORT ANSWERS 10 x 2 = 20 Marks
- Indicate the direction of dipole moment for the following:a) Nitrogen triflouride b) water
- Arrange the following in the increasing order of acidity: H2O, H2S, NH3, H2SO4.
- What is crossed Aldol condensation? Give the equation.
- How will you assay Chlorbutol?
- Write the IUPAC names for the following.
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OH
b)
CI - What are ring activators? Classify them.
- Draw the cis-and trans- Geometrical isomers of 2-methyl-3-heptene.
- Give the structure and uses of : a) Mephenesin b) Saccharin sodium
- Explain why aldehydes undergo nuclephillic additions faster than ketones
- Give the structure and IUPAC name for: (a) Ethyl acetate (b) Lactic acid.
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