Rajiv Gandhi University of Health Sciences, Karnataka
III Year Pharma-D Degree Examination – Sep 2012
Time: Three Hours
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Max. Marks: 70 Marks
MEDICINAL CHEMSITRY
Q.P. CODE: 2865
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
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LONG ESSAYS 2 x 10 = 20 Marks
- Define antibiotics? Classify antibiotics and give one examples of drug with structure under each class. Write the of development of acid resistant and extended spectrum penicillins
- Define and classify anti-infective agents with two examples of drugs with structures under each class. Add note on structure activity relationships of quinolones
- Classify antimalarial agents with examples. Write the mechanism of action, synthesis and uses of chloroquine
SHORT ESSAYS 6 x 5 = 30 Marks
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- Write the chemistry and mechanism of action of ACE inhibitors
- Give four chemical structures of drugs belong to oral hypoylycemic agents and outline the synthesis of tolbutamide
- Classify diuretics with examples. Write the structure activity relationships of thiazide diuretics
- Classify anti-Arrhythmic agents with examples. Write the synthesis of any one anti-Arrhythmic agent
- Write the mode of action, chemical structure and therapeutic use of cycloserine
- Justify, sulfamethoxazole and trimethoprim combination is effective in antibacterial therapy
- Write the method of synthesis and applications of combinatorial synthesis
- Explain how antimetabolities act as antineoplastic agents with suitable examples
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SHORT ANSWERS 10 x 2 = 20 Marks
- Write the chemical structure of sulfonamide used in ophthalmic infection
- Write the synthesis of hexyl resorcinol
- Write the chemical structure and uses of testosterone
- Mention the types of hyperlipoproteinemia
- Why tetracyclines are not effective in presence of milk and metals
- Write the chemical structure and uses of thyroxin
- Define scabicide with examples
- Write the chemical structure and uses of diethyl stilbosterol
- Write the mechanism of action of amino glycoside antibiotics
- Define prodrug with examples
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