Rajiv Gandhi University of Health Sciences, Karnataka
IV Year Pharma-D Degree (Post Baccalaureate) Examination – Sep 2012
Time: Three Hours
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Max. Marks: 70 Marks
BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. CODE: 2871
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
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LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
- Define drug absorption. Explain different mechanisms of drug absorption.
- Explain concept of compartment kinetics. How do you determine kinetic constants following intravenous bolus of a drug confirming to two compartment model.
- Define Bioavailability? Explain different methods to measure bioavailability.
SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
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- Discuss drug accumulation during multiple dosing.
- What are pharmacodynamic models? Explain few models used to quantify plasma concentration response relationship.
- Explain organ clearance.
- Explain two types of bioequivalence experimental study design
- Explain biological factors affecting biotransformation of drugs
- Explain limitations of pH partition hypothesis.
- Explain any four dosage form characteristics that affect absorption of drugs.
- If the initial plasma concentration of a drug is 0.49mcg/ml when administered at an intravenous bolus dose of 80mg, calculate volume of distribution and total clearance. The half life of the drug is 2.5 hours.
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SHORT ANSWERS 10 x 2 = 20 Marks
- How do disease states influence gastric emptying?
- Quote tests to determine nonlinearity in pharmacokinetics.
- Enlist four biological factors affecting absorption of drugs.
- Give examples for zero order rate processes.
- Define first pass metabolism and enlist the three primary systems affecting first pass metabolism
- Enlist the specialized physiological barriers to distribution of drugs.
- Why is conjugation with glucuronic acid most common and important phase II reaction?
- Give the advantages and disadvantages to noncompartmental approach.
- How are body tissues broadly classified in the two compartment model?
- Give significance of area under curve in pharmacokinetics.
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