Firstranker's choice
Rajiv Gandhi University of Health Sciences, Karnataka
--- Content provided by FirstRanker.com ---
V Year Pharma-D Post Baccalaureate Degree Examination – Sep 2012
Time: Three Hours
Max. Marks: 70 Marks
CLINICAL PHARMACOKINETICS & THERAPEUTIC DRUG MONITORING
Q.P. CODE: 2876
--- Content provided by FirstRanker.com ---
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
- What is Bayesian theory? Explain with a suitable example. Briefly explain the concept of dosing with feedback.
- Explain the basis and different methods of dose adjustment in uremia condition
- Write a typical protocol for TDM of a drug. Explain the TDM of Cyclosporine.
--- Content provided by FirstRanker.com ---
SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
- Explain the methods of determining creatinine clearance.
- Dosage adjustment in Pediatrics is essential. Explain mentioning the different methods used in child dose calculation
- Discuss the effect of hepatic diseases on Pharmacokinetics
- Explain the principle of conversion of drug dose from intra-venous to oral route with an example
- Explain with examples how drug efflux transporters influence the bioavailability of drugs
- How does elimination half life influence the duration of activity of drugs? Give examples.
- What is extracorporeal removal of drugs? Explain.
- Explain the importance enzyme induction and inhibition in drug interactions with examples.
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
SHORT ANSWERS 10 x 2 = 20 Marks
- What are the factors influencing individualization of drug dosage regimens
- Give examples of drug interactions influencing drug elimination
- Write the applications of nomograms
- Enumerate the methods used to determine GFR
- What is the NONMEM model and what is its application?
- The maintenance dose of Gentamicin is 80 mg every 6 hours in a patient with normal renal function (normal creatinine clearance of 100 ml/min). calculate the dose for a uremic patient with creatinine clearance of 20ml/min (given Ku/KN = 0.2
- Define genetic polymorphism and give examples
- List the factors influencing dialyzability of drugs
- What are hepatic metabolic markers? Give examples.
- Dosing of drugs in obese patients is important. Why?
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
*****
--- Content provided by FirstRanker.com ---
This download link is referred from the post: RGUHS Pharma-D Last 10 Years 2011-2021 Previous Question Papers || Rajiv Gandhi University of Health Sciences