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Rajiv Gandhi University of Health Sciences, Karnataka
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I Year Pharma-D Examination – Sep 2012
Time: Three Hours
Max. Marks: 70 Marks
PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. CODE: 2854
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Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- State and explain Friedel Crafts alkylation with its limitations. Write a note on Friedel Crafts acylation.
- Write the kinetics, orientation and mechanism involved in E1 and E2 reactions.
- Explain in detail the mechanism of nucleophilic acyl substitution. Write the effect of different functional groups on the reactivity.
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Explain the stability of conjugated dienes.
- Discuss the role of solvent in Sn1 and SN2 reaction.
- Write a note on dehydration of alcohols.
- Give the mechanism of 1, 2-and 1, 4-addition reaction.
- Define and explain the terms acids and bases based on Lowry-Bronsted and Lewis theories.
- Write short notes on: (a) Intermolecular forces. (b) Effect of hydrogen bonding on boiling point.
- Explain with mechanism (a) Benzoin condensation (b) Claisen's condensation.
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SHORT ANSWERS 10 x 2 = 20 Marks
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- Discuss Markovnikov's rule with example.
- Give Saytzeff's rule with example.
- Write the preparation and medicinal uses of mephensin.
- Give the assay of methyl salicylate.
- Give the structures of (a) 2-Iodo 2-Propanol (b) Ethyl ethanoate.
- Give the structure and medicinal uses of (a) Vanillin (b) Nitroglycerin.
- What are Diel's Alder reactions? Give an example.
- Define activating and deactivating groups with examples.
- Give the orbital picture of allyl radical.
- Define polarity of bonds.
- Which is more stable; trans-2-butene or cis-2-butene? Why?
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