Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Year Pharm D Degree (Post Baccalaureate) Examination – Feb/March 2011
Time: Three Hours Max. Marks: 70 Marks
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BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. CODE: 2871
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
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- Discuss one compartment model after administration of an intravenous bolus. How do you determine pharmacokinetic parameters?
- Explain in detail with examples, the importance of pH partition theory to explain passive absorption of drugs
- Discuss Michaelis Menten equation along with estimation of Km and Vmax.
SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
- Explain in vitro- in vivo correlation
- Discuss urinary excretion studies in determination of Bioavailability.
- Discuss volume of distribution with significance.
- Explain advantages of administering drug by constant rate intravenous infusion.
- Describe glucuronic acid conjugation and its importance in drug metabolism
- What are the experimental methods for studying absorption of drugs?
- Discuss loading dose and maintenance dose
- Drug X when administered at an intravenous bolus dose of 75 mg showed initial plasma concentration of 0.98 mcg/ml. the half life of the drug is 2.7 hours. Calculate volume of distribution and total clearance
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SHORT ANSWERS 10 x 2 = 20 Marks
- Give the mechanism of pore transport in absorption of drugs
- How dose composition of meal and body posture influence gastric emptying?
- Define the terms Pharmacokinetics and Bioequivalence.
- How dose diet affect drug distribution?
- Quote advantages of Latin square design in bioequivalence experimental study.
- In compartment modeling, what does the term 'open' mean?
- Define elimination half- life and give its equation.
- What are the primary objectives of phase I reactions?
- List two methods to improve stability of drug in gastrointestinal tract with examples
- Enlist four applications of compartment pharmacokinetic models
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