Download RGUHS (Rajiv Gandhi University of Health Sciences) Pharm.D (Doctor of Pharmacy) 4th Semester 2011 Feb 2871 Biopharmaceutics And Pharmacokinetics Question Paper.
Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Year Pharm D Degree (Post Baccalaureate) Examination ? Feb/March 2011
Time: Three Hours Max. Marks: 70 Marks
BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. CODE: 2871
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
1.
Discuss one compartment model after administration of an intravenous bolus. How do you
determine pharmacokinetic parameters?
2.
Explain in detail with examples, the importance of pH partition theory to explain passive
absorption of drugs
3
Discuss Michaelis Menten equation along with estimation of K
m
and V
max
.
SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
4.
Explain in vitro- in vivo correlation
5.
Discuss urinary excretion studies in determination of Bioavailability.
6.
Discuss volume of distribution with significance.
7.
Explain advantages of administering drug by constant rate intravenous infusion.
8.
Describe glucuronic acid conjugation and its importance in drug metabolism
9.
What are the experimental methods for studying absorption of drugs?
10.
Discuss loading dose and maintenance dose
11.
Drug X when administered at an intravenous bolus dose of 75 mg showed initial plasma
concentration of 0.98 mcg/ml. the half life of the drug is 2.7 hours. Calculate volume of
distribution and total clearance
SHORT ANSWERS 10 x 2 = 20 Marks
12.
Give the mechanism of pore transport in absorption of drugs
13.
How dose composition of meal and body posture influence gastric emptying?
14.
Define the terms Pharmacokinetics and Bioequivalence.
15.
How dose diet affect drug distribution?
16.
Quote advantages of Latin square design in bioequivalence experimental study.
17.
In compartment modeling, what does the term ? open ? mean?
18.
Define elimination half- life and give its equation.
19.
What are the primary objectives of phase I reactions?
20.
List two methods to improve stability of drug in gastrointestinal tract with examples
21.
Enlist four applications of compartment pharmacokinetic models
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This post was last modified on 20 December 2019