Roll No:
Application No:
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Exam Date: 06-Oct-2020
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Exam Time: 09:00-12:00Examination: 1. Course Code - Ph.D.
2. Field of Study - Molecular Medicine (CMMH)
SECTION 1 - SECTION 1
Question No.1 (Question Id - 29)
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Quorum Sensing was first reported in Aliivibriofischeri. This is described as :(A)
Cell to cell communication system in gram negative bacteria
(B)
A signaling system in biofilms
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(C)A process that helps bacteria sense quorum
(D)
All of the above (Correct Answer)
Question No.2 (Question Id - 45)
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Increases in concentration of the second messenger cAMP may lead to the activation of:
(A)
cyclic nucleotide-gated ion channels
(B)
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popeye domain containing proteins(C)
protein kinase A
(D)
all of the above (Correct Answer)
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Question No.3 (Question Id - 35)Typical examples of human zymogens are :
(A)
Trypsinogen
(B)
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Proelastase(C)
Prolipase
(D)
All of the above (Correct Answer)
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Question No.4 (Question Id - 9)The phenol-chloroform method of DNA extraction depends on the fact that :
(A)
Water and phenol mixture create non-polar solvent
(B)
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Phenol is lighter than water(C)
DNA is a polar molecule with a net negative charge (Correct Answer)
(D)
None of the above
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Question No.5 (Question Id - 27)Q-cytochrome c oxidoreductase is also called :
(A)
complex III (Correct Answer)
(B)
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cytochrome cII reductase(C)
cytochrome bc3 complex
(D)
none of the above
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Question No.6 (Question Id - 12)Newton's second law states that :
(A)
the acceleration of an object is dependent indirectly upon the net force acting
upon the object
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(B)the acceleration of an object is dependent upon the net force acting upon
the object and the mass of the object
(Correct Answer)
(C)
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the acceleration of an object does not depend on the mass of the object(D)
none of the above
Question No.7 (Question Id - 17)
The complete Freund's Adjuvant contains :
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(A)inactivated Mycobacterium tuberculosis (Correct Answer)
(B)
heat killed Escherichia coli
(C)
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Lipopolysaccharides from Escherichia coli(D)
None of the above
Question No.8 (Question Id - 41)
The linear magnification of eyepiece and objective lens of a microscope is 20x and
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10x respectively. Therefore, the net magnification of the microscope will be(A)
20x
(B)
30x
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(C)200x (Correct Answer)
(D)
10x
Question No.9 (Question Id - 13)
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Choose the statement that correctly applies to the Joule-Thomson effect :(A)
The principle of Joule-Thomson effect helps explain the change in temperature
that accompanies expansion of a gas without transfer of heat
(B)
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The principle of Joule-Thomson effect is often utilized in liquefying gases(C)
Joule-Thomson effect is also called as Kelvin-Joule effect or Joule-Kelvin effect
(D)
All of the above (Correct Answer)
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Question No.10 (Question Id - 11)The Brnsted-Lowry theory describes :
(A)
the law of constant proportions
(B)
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an acid is a molecule or ion that can donate a proton (Correct Answer)(C)
the pressure of a given mass of an ideal gas is inversely proportional to its
volume
(D)
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none of the aboveQuestion No.11 (Question Id - 33)
Mitogen-activated protein kinases (MAPKs) are :
(A)
Serine/threonine kinases
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(B)
Respond to extracellular stimuli (mitogens)
(C)
Regulate various mitosis, differentiation and apoptosis.
(D)
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All of the above (Correct Answer)Question No.12 (Question Id - 50)
Cytochromes play important roles in electron transport chain. The following applies role
of cytochromes during oxidative phosphorylation.
(A)
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Globular Cytochrome C is important for complex III and complex IV(B)
Complex III itself is composed of a b-type cytochrome
(C)
Complex III itself is composed of a a-type cytochrome
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(D)All of the above (Correct Answer)
Question No.13 (Question Id - 20)
RNA dependent RNA polymerase is NOT found in which of the following viruses ?
(A)
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Dengue virus(B)
Chikungunya virus
(C)
SARS-COV 2 virus
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(D)Human Immunodeficiency virus (Correct Answer)
Question No.14 (Question Id - 34)
Glia, also called glial cells in the central nervous system are :
(A)
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non-neuronal cells(B)
do not produce electrical impulses
(C)
important since they supply nutrients and oxygen to neurons
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(D)all of the above (Correct Answer)
Question No.15 (Question Id - 43)
T helper type 2 (Th2) cells are a distinct lineage of CD4+ effector T cells, which secretes
:
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(A)IL-4 (Correct Answer)
(B)
IL-1
(C)
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IL-6(D)
All of the above
Question No.16 (Question Id - 32)
Angiogenesis is the physiological process which is important in :
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(A)generation of new blood vessels
(B)
wound healing
(C)
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tumor progression(D)
all of the above (Correct Answer)
Question No.17 (Question Id - 38)
Chromatin immunoprecipitation (ChIP) is used to study interaction between proteins and
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DNA. The following statement correctly applies to the assay :(A)
In cross-linked ChIP (XChIP) chromatin sheared by sonication is used
(Correct Answer)
(B)
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In cross-linked ChIP (XChIP) purified whole chromatin is used(C)
In Native ChIP (NChIP) native chromatin sheared by sonication is used
(D)
All statements are correct
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Question No.18 (Question Id - 23)The mechanisms of resistance to chloramphenicol are :
(A)
reduced membrane permeability
(B)
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mutation of the 50S ribosomal subunit(C)
elaboration of chloramphenicol acetyltransferase
(D)
all of the above (Correct Answer)
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Question No.19 (Question Id - 37)The subunits of human NF-KB (nuclear factor kappa-light-chain-enhancer of activated B
cells) are :
(A)
c-Rel (Correct Answer)
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(B)Rel D
(C)
b-Rel
(D)
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e-RelQuestion No.20 (Question Id - 30)
What volume of 0.05 M H2SO4 will be required to completely neutralize 15 ml of 0.2 N
NaOH solution ?
(A)
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30 ml of 0.05 M H2SO4 (Correct Answer)(B)
0.1 ml of 5 M H2SO4
(C)
3 ml of 1 M H2SO4
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(D)30 ml of 0.5 M H2SO4
Question No.21 (Question Id - 2)
Chromatin immunoprecipitation is :
(A)
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commonly abbreviated as ChIP assays (Correct Answer)(B)
used for RNA-protein binding assays
(C)
used for karyotyping assays
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(D)all of the above
Question No.22 (Question Id - 48)
Sumoylation of proteins is a post-translational modification where proteins are
conjugated with :
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(A)ubiquitin
(B)
small ubiquitin-like modifiers (Correct Answer)
(C)
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secretory ubiquitin methylation(D)
none of the above
Question No.23 (Question Id - 4)
One nanometer (nm) is equal to :
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(A)
one millionth of a millimeter (mm)
(B)
one-billionth of a meter (m)
(C)
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one thousand picometer (pm)(D)
all of the above (Correct Answer)
Question No.24 (Question Id - 25)
Succinate-Q oxidoreductase is characterized by :
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(A)the term complex III
(B)
being the first entry point to the electron transport chain
(C)
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being the only enzyme that is part of both the citric acid cycle and theelectron transport chain
(Correct Answer)
(D)
all of the above
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Question No.25 (Question Id - 18)Two proteins of the same molecular weight, size, shape and charge can still be
separated by :
(A)
Gel filtration chromatography
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(B)Affinity chromatography (Correct Answer)
(C)
Ion-exchange chromatography
(D)
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Thin layer chromatographyQuestion No.26 (Question Id - 14)
The Second Law of Thermodynamics states that :
(A)
entropy constantly increases in a closed system (Correct Answer)
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(B)energy can neither be created nor destroyed: it can only change form
(C)
entropy constantly decreases in a closed system
(D)
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none of the aboveQuestion No.27 (Question Id - 31)
The function of adrenocorticotropic hormone is to :
(A)
Stimulate secretion of pepsin
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(B)Stimulate neuro-transmission
(C)
Stimulate secretion of steroid hormones (Correct Answer)
(D)
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None of the aboveQuestion No.28 (Question Id - 22)
Nalidixic acid is a synthetic quinolone antibiotics. It functions as :
(A)
Protein synthesis inhibitor in gram negative bacteria
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(B)Membrane disruption agent in gram positive bacteria
(C)
Inhibitor of bacterial motility
(D)
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None of the above (Correct Answer)Question No.29 (Question Id - 28)
Toll like Receptors (TLRs) are fundamental determinants of innate immunity. A possible
ligand for TLR is :
(A)
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Teichoic acids of gram negative bacteria(B)
Pathogen Associated Molecular Patterns (Correct Answer)
(C)
Viral Lipopolysaccharides
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(D)All of the above
Question No.30 (Question Id - 46)
The theoretical maximum yield of ATP through oxidation of one molecule of glucose
in glycolysis, citric acid cycle, and oxidative phosphorylation is :
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(A)36
(B)
38 (Correct Answer)
(C)
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40(D)
28
Question No.31 (Question Id - 15)
Reverse Phase High Performance Liquid Chromatography (RP-HPLC) commonly uses
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C18 and C8 columns. Select the incorrect statement about these columns :(A)
C18 has a longer carbon chain while C8 has a shorter carbon chain
(B)
C18 has a lower retention while C8 has a higher retention (Correct
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Answer)(C)
C18 has a higher hydrophobicity, then C8 (Correct Answer)
(D)
Both columns use organic solvents in their mobile phase (Correct
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Answer)Question No.32 (Question Id - 3)
Streptavidin and Biotin are widely used in molecular biology assays. This is because :
(A)
Streptavidin homo-tetramers bind to vitamin B7 with high affinity
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(B)The dissociation constant (Kd) of Streptavidin-biotin binding is on the order of
10-14 mol/L
(C)
Streptavidin-biotin complex is relatively resistant to organic solvents
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(D)All of the above (Correct Answer)
Question No.33 (Question Id - 16)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are members of a drug class that :
(A)
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inhibit cyclooxygenase enzymes (COX-1 or COX-2) (Correct Answer)(B)
upregulate the synthesis of prostaglandins
(C)
decrease risk of gastrointestinal ulcers upon prolonged use
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(D)all of the above
Question No.34 (Question Id - 21)
Cycloheximide is a naturally occurring fungicide produced by the bacterium
Streptomyces griseus. It is used in molecular biology experiments because it can be
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used to :(A)
Interfere with eukaryotic translational elongation
(B)
Ribosome profiling/translational profiling
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(C)Study the half-life of a protein
(D)
All of the above (Correct Answer)
Question No.35 (Question Id - 47)
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The measure of the total binding strength of an antibody at every binding site is termedas :
(A)
Affinity
(B)
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Avidity (Correct Answer)(C)
Titer
(D)
None of the above
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Question No.36 (Question Id - 7)Choose the number of moles of the product formed in the following chemical reaction :
Al4C3 + 12H20 = __________ + 3CH4
(A)
Al2OH2
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(B)4AlO2
(C)
4Al(OH)2
(D)
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None of the above (Correct Answer)Question No.37 (Question Id - 10)
Curcumin, the primary bioactive substance in turmeric is :
(A)
made by Curcuma longa plants
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(B)a natural polyphenol
(C)
a phyto-medicine with anti-inflammatory properties
(D)
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all of the above (Correct Answer)Question No.38 (Question Id - 6)
EDTA is a chemical that chelates minerals and metals. The full form of EDTA is :
(A)
Ethyldimethyltetraacetic acid
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(B)Ethylenediaminetriacetic acid
(C)
Ethoxydioxytriacetic acid
(D)
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Ethylenediaminetetraacetic acid (Correct Answer)Question No.39 (Question Id - 24)
Choose which of the following events occur during oxidative phosphorylation :
(A)
electrons are transferred from electron donors to electron acceptors such as
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oxygen in redox reactions(B)
redox reactions release the energy stored in the relatively weak double bond of
O2
(C)
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reactive oxygen species such as superoxide and hydrogen peroxide is formed(D)
all of the above (Correct Answer)
Question No.40 (Question Id - 42)
Koch's postulates for infectious disease states that :
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(A)The microorganism must be found the organism suffering from the
disease, but should not be found in healthy organism.
(Correct Answer)
(B)
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The microorganism must be isolated from the asymptomatic and symptomaticorganisms suffering from the disease
(C)
The cultured microorganism should not cause disease when infected in an
organism resistant to the disease
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(D)All of the above
Question No.41 (Question Id - 36)
A leucine zipper is a common three-dimensional structural motif in proteins. The
following statement that best apply to these proteins :
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(A)Leucine zippers are -helices that contain a leucine residue every seventh
amino acid.
(B)
This motif is found in many eukaryotic transcription factors.
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(C)Zing fingers are not leucine zipper proteins
(D)
All of the above statements are correct (Correct Answer)
Question No.42 (Question Id - 1)
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An endospore forming bacteria may be isolated from a mixture of non-sporulatingbacteria in solution using the following technique :
(A)
exposing the solution to sunlight for 15 min.
(B)
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boiling the sample at 80?C for 20 min. (Correct Answer)(C)
incubating the sample in 10% formaldehyde for 1 h.
(D)
exposing the solution to gamma-radiation for 15 min.
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Question No.43 (Question Id - 19)Post-translational modifications of a biological molecule in a living cell can be studied by
:
(A)
Nexgen sequencing
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(B)Proteomics (Correct Answer)
(C)
Transcriptomics
(D)
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Polymerase Chain ReactionQuestion No.44 (Question Id - 26)
The type II secretion system is a membrane bound protein complex found in Gram-
negative bacteria. The following apply to this complex :
(A)
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It has an outer membrane complex made up by the secretin GspD.(B)
GspD are -barrels shaped structures in the bacterial membrane
(C)
GspD creates a pore in the outer membrane of the bacterial cell
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(D)All of the above (Correct Answer)
Question No.45 (Question Id - 40)
The amount of a peptide with molecular weight 300 daltons required to make a
10mM solution in 1mL water is :
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(A)3 ?g
(B)
3 mg (Correct Answer)
(C)
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300 mg(D)
10 mg
Question No.46 (Question Id - 8)
A Grignard reagent has a generic formula R-Mg-X, where X is a halogen and R is an
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organic group. These reagents are :(A)
widely used in organic synthesis for creating new carbon-carbon bonds
(B)
good nucleophiles
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(C)normally handled as solutions in solvents like diethyl ether or tetrahydrofuran
(D)
all of the above (Correct Answer)
Question No.47 (Question Id - 49)
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Escherichia coli Strain Nissle 1917 is :(A)
a probiotic strain (Correct Answer)
(B)
an EPEC strain
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(C)an EHEC strain
(D)
none of the above
Question No.48 (Question Id - 44)
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A person with fever checks at 39?C. This means the temperature of this person is :(A)
102.2?F (Correct Answer)
(B)
103.4?F
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(C)101?F
(D)
None of the above
Question No.49 (Question Id - 39)
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The natural antibiotic present in mother's milk of homo sapiens is :(A)
Granzyme
(B)
Lipid A
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(C)Lactoferrin (Correct Answer)
(D)
Hepcidin
Question No.50 (Question Id - 5)
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What is 98.6 ?F in degrees Celsius ?(A)
37.0?C (Correct Answer)
(B)
30.0?C
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(C)100.0?C
(D)
None of the above
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