Download PTU B.Tech 2020 March Biotechnology 7th and 8th Sem BTBT 703 Genomics And Proteomics Question Paper

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Roll No. [ LTI T] | Total No. of Pages : 02
Total No. of Questions : 09

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B.Tech.(BT) (2012 to 2017) (Sem.-7)
GENOMICS AND PROTEOMICS
Subject Code : BTBT-703
M.Code : 71845
Time : 3 Hrs. Max. Marks : 60

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INSTRUCTION TO CANDIDATES :

1. SECTION-A is COMPULSORY consisting of TEN questions carrying TWO marks each.
2. SECTION-B contains FIVE questions carrying FIVE marks each and students have to attempt any FOUR questions.
3. SECTION-C contains THREE questions carrying TEN marks each and students have to attempt any TWO questions.

SECTION-A

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1. Write briefly :
   1. Define SNP.
   2. What is whole genome shotgun sequencing?
   3. Define pseudogenes.
   4. What is the advantage of using fluorescent probes over radioactive probes in microarray analysis?
   5. What is the application of mass spectrometry in proteomics?

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   6. What is the application of homology modeling in structural proteomics?
   7. What is the importance of databases of Protein-Protein interactions?
   8. What do you understand by eukaryotic clusters of orthologous groups (KOGs)?
   9. What were the goals of human genome project?
   10. What is the application of Nuclear Magnetic Resonance (NMR) spectroscopy in structural proteomics?

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SECTION-B

2. Compare microarray based transcriptome analysis with proteome analysis approaches for studying global gene expression.
3. Describe RAPD analysis. Comment on its advantages and limitations.
4. With the help of suitable example write importance of comparative genomics of bacteria.

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5. Discuss the printing technology for producing spotted arrays.
6. Write about a comparative genomics based method to study protein- protein interactions.

SECTION-C

7. Using schematic diagram, describe SAGE. Compare SAGE with microarray technology.
8. Describe 2D gel electrophoresis and its application in proteomics.

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9. Describe AFLP with the help of schematic diagram.

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.