Download Hemwati Nandan Bahuguna Uttarakhand Medical Education University (HNBUMU) Medical Entrance Exam 2020 Jan Pharmacology Question Paper With Answer Previous Question Paper With Solution
Hemwati Nandan Bahuguna Uttarakhand Medical
Education University?
Administrative?Block,?Govt.?Doon?Medical?College?Campus,?Dehrakhas,??
Patel?Nagar,?Dehradun???248001?
Phone:?0135???2723323?Fax:? 0135???2723323?
Website: www.hnbumu.ac.in? E?mail:?info.hnbumu@gmail.com
?
?
Ph.D. ENTRANCE EXAMINATION - 2020
?
?
Subject? :??Pharmacology? ? ??????????? Duration:?01:30?Hrs.?
Date?? :??06.01.2020? ? ??????????? Place?:?Dehradun?
Max?Marks:?60?? ?
?
?
?
?
?
?
?
Student?Name:??????Invigilator?Name:??
?
FirstRanker.com - FirstRanker's Choice
Hemwati Nandan Bahuguna Uttarakhand Medical
Education University?
Administrative?Block,?Govt.?Doon?Medical?College?Campus,?Dehrakhas,??
Patel?Nagar,?Dehradun???248001?
Phone:?0135???2723323?Fax:? 0135???2723323?
Website: www.hnbumu.ac.in? E?mail:?info.hnbumu@gmail.com
?
?
Ph.D. ENTRANCE EXAMINATION - 2020
?
?
Subject? :??Pharmacology? ? ??????????? Duration:?01:30?Hrs.?
Date?? :??06.01.2020? ? ??????????? Place?:?Dehradun?
Max?Marks:?60?? ?
?
?
?
?
?
?
?
Student?Name:??????Invigilator?Name:??
?
Signature:???????Signature:?
01. The steady-state concentration of a drug can be double by:
a. Doubling?the?both?rate?of?infusion?and?concentration?of? drug.?
b. Doubling?the?rate?of?infusion?only.?
c. Doubling?the?loading?dose?but?maintaining?the?infusion? rate.?
d. Tripling?the?rate?of?infusion.?
02. Phase II reactions of a drug biotransformation:
a. Decreases?its?water?solubility.?
b. Includes?activity?of?cytochrom?P?450.?
c. Usually?leads?to?inactivation?of?the?drug.?
d. Does?not?include?acetylation.?
03. Half-life of a drug may be helpful to determine:
a. Dosage?schedule?of?the?drug.?
b. Level?of?absorption.?
c. Distribution?into?different?body?systems.?
d. Time?to?get?the?steady?state.?
04. A 3 year old child has been admitted to emergency with suspicious of atropine
overdose as there are:
a. Abdominal?cramps.?
b. Increased?gastric?secretion.?
c. Increased?cardiac?rate.?
d. Papillary?constriction.?
?
05. Epinephrine does not cause increase concentrations of:
a. Glucose?in?blood.?
b. Lactate?in?blood.?
c. Free?fatty?acids?in?blood.?
d. Triglycerides?in?fat?cells.?
?
06. A 50 year old patient is having propranolol due to his cardiac problems but his
physician now wants to stop this drug; which of the following is the most
important reason for this step?
a. Familial?tremor.?
b. Partial?AV?heart?block.?
c. Mild?hypertension.?
d. Angina?pectoris.?
07. A young man of 24 years is suffering from Generalized Anxiety Disorder; which
drug may be preferred for his problem?
a. Zolpidem.?
FirstRanker.com - FirstRanker's Choice
Hemwati Nandan Bahuguna Uttarakhand Medical
Education University?
Administrative?Block,?Govt.?Doon?Medical?College?Campus,?Dehrakhas,??
Patel?Nagar,?Dehradun???248001?
Phone:?0135???2723323?Fax:? 0135???2723323?
Website: www.hnbumu.ac.in? E?mail:?info.hnbumu@gmail.com
?
?
Ph.D. ENTRANCE EXAMINATION - 2020
?
?
Subject? :??Pharmacology? ? ??????????? Duration:?01:30?Hrs.?
Date?? :??06.01.2020? ? ??????????? Place?:?Dehradun?
Max?Marks:?60?? ?
?
?
?
?
?
?
?
Student?Name:??????Invigilator?Name:??
?
Signature:???????Signature:?
01. The steady-state concentration of a drug can be double by:
a. Doubling?the?both?rate?of?infusion?and?concentration?of? drug.?
b. Doubling?the?rate?of?infusion?only.?
c. Doubling?the?loading?dose?but?maintaining?the?infusion? rate.?
d. Tripling?the?rate?of?infusion.?
02. Phase II reactions of a drug biotransformation:
a. Decreases?its?water?solubility.?
b. Includes?activity?of?cytochrom?P?450.?
c. Usually?leads?to?inactivation?of?the?drug.?
d. Does?not?include?acetylation.?
03. Half-life of a drug may be helpful to determine:
a. Dosage?schedule?of?the?drug.?
b. Level?of?absorption.?
c. Distribution?into?different?body?systems.?
d. Time?to?get?the?steady?state.?
04. A 3 year old child has been admitted to emergency with suspicious of atropine
overdose as there are:
a. Abdominal?cramps.?
b. Increased?gastric?secretion.?
c. Increased?cardiac?rate.?
d. Papillary?constriction.?
?
05. Epinephrine does not cause increase concentrations of:
a. Glucose?in?blood.?
b. Lactate?in?blood.?
c. Free?fatty?acids?in?blood.?
d. Triglycerides?in?fat?cells.?
?
06. A 50 year old patient is having propranolol due to his cardiac problems but his
physician now wants to stop this drug; which of the following is the most
important reason for this step?
a. Familial?tremor.?
b. Partial?AV?heart?block.?
c. Mild?hypertension.?
d. Angina?pectoris.?
07. A young man of 24 years is suffering from Generalized Anxiety Disorder; which
drug may be preferred for his problem?
a. Zolpidem.?
b. Buspiron.?
c. Midazolam.?
d. Triazolam.?
08. Which of the following statements best describes the
mechanism of action of benzodiazepines?
a. Benzodiazepines?activate?GABA
B?
?receptors?in?the?spinal?cord.?
b. They?inhibit?GABA?transaminase?leading?to?increased?levels?of?GABA.?
c. They?block?glutamate?receptors??in?hierarchical?neuronal?pathways?in?the?brain.?
d. Benzodiazepines? increase? the? frequency? of? Cl
??
?channels?opening?which?are?
coupled?to?GABA
A?
receptors.?
09. Which of the following drugs when used for prolonged period in the
maintenance treatment of tonic-clonic seizures can lead to increased
metabolism of warfarin like drugs?
a. Phenobarbital.?
b. Meprobamate.?
c. Chlordiazepoxide.?
d. Triazolam.?
?
10. Characteristics of non-depolarizing neuromuscular blockade include which of
the following?
a. Block?of?post?tetanic?potentiation.?
b. Histamine?blocking?action.?
c. Poorly?sustained?tetanic?tension.?
d. Significant?muscle?fasciculations?during?onset?of?block.?
11. Which of the following drugs given preoperatively is used to prevent
postoperative pain caused by succinylcholine?
a. Dantrolene.?
b. Tubocurarine.?
c. Diazepam.?
d. Lidocaine.?
12. With prolonged use in seizure states, which of the following drugs can cause
coarsening of facial features, hirsutism, gingival hyperplasia and osteomalacia?
a. Valproic?acid.?
b. Carbamazepine.?
c. Ethosuximide.?
d. Phenytoin.?
?
13. Only Aspirin can:
a. Reduce?fever.?
b. Irreversible?inhibit?its?target?enzyme.?
FirstRanker.com - FirstRanker's Choice
Hemwati Nandan Bahuguna Uttarakhand Medical
Education University?
Administrative?Block,?Govt.?Doon?Medical?College?Campus,?Dehrakhas,??
Patel?Nagar,?Dehradun???248001?
Phone:?0135???2723323?Fax:? 0135???2723323?
Website: www.hnbumu.ac.in? E?mail:?info.hnbumu@gmail.com
?
?
Ph.D. ENTRANCE EXAMINATION - 2020
?
?
Subject? :??Pharmacology? ? ??????????? Duration:?01:30?Hrs.?
Date?? :??06.01.2020? ? ??????????? Place?:?Dehradun?
Max?Marks:?60?? ?
?
?
?
?
?
?
?
Student?Name:??????Invigilator?Name:??
?
Signature:???????Signature:?
01. The steady-state concentration of a drug can be double by:
a. Doubling?the?both?rate?of?infusion?and?concentration?of? drug.?
b. Doubling?the?rate?of?infusion?only.?
c. Doubling?the?loading?dose?but?maintaining?the?infusion? rate.?
d. Tripling?the?rate?of?infusion.?
02. Phase II reactions of a drug biotransformation:
a. Decreases?its?water?solubility.?
b. Includes?activity?of?cytochrom?P?450.?
c. Usually?leads?to?inactivation?of?the?drug.?
d. Does?not?include?acetylation.?
03. Half-life of a drug may be helpful to determine:
a. Dosage?schedule?of?the?drug.?
b. Level?of?absorption.?
c. Distribution?into?different?body?systems.?
d. Time?to?get?the?steady?state.?
04. A 3 year old child has been admitted to emergency with suspicious of atropine
overdose as there are:
a. Abdominal?cramps.?
b. Increased?gastric?secretion.?
c. Increased?cardiac?rate.?
d. Papillary?constriction.?
?
05. Epinephrine does not cause increase concentrations of:
a. Glucose?in?blood.?
b. Lactate?in?blood.?
c. Free?fatty?acids?in?blood.?
d. Triglycerides?in?fat?cells.?
?
06. A 50 year old patient is having propranolol due to his cardiac problems but his
physician now wants to stop this drug; which of the following is the most
important reason for this step?
a. Familial?tremor.?
b. Partial?AV?heart?block.?
c. Mild?hypertension.?
d. Angina?pectoris.?
07. A young man of 24 years is suffering from Generalized Anxiety Disorder; which
drug may be preferred for his problem?
a. Zolpidem.?
b. Buspiron.?
c. Midazolam.?
d. Triazolam.?
08. Which of the following statements best describes the
mechanism of action of benzodiazepines?
a. Benzodiazepines?activate?GABA
B?
?receptors?in?the?spinal?cord.?
b. They?inhibit?GABA?transaminase?leading?to?increased?levels?of?GABA.?
c. They?block?glutamate?receptors??in?hierarchical?neuronal?pathways?in?the?brain.?
d. Benzodiazepines? increase? the? frequency? of? Cl
??
?channels?opening?which?are?
coupled?to?GABA
A?
receptors.?
09. Which of the following drugs when used for prolonged period in the
maintenance treatment of tonic-clonic seizures can lead to increased
metabolism of warfarin like drugs?
a. Phenobarbital.?
b. Meprobamate.?
c. Chlordiazepoxide.?
d. Triazolam.?
?
10. Characteristics of non-depolarizing neuromuscular blockade include which of
the following?
a. Block?of?post?tetanic?potentiation.?
b. Histamine?blocking?action.?
c. Poorly?sustained?tetanic?tension.?
d. Significant?muscle?fasciculations?during?onset?of?block.?
11. Which of the following drugs given preoperatively is used to prevent
postoperative pain caused by succinylcholine?
a. Dantrolene.?
b. Tubocurarine.?
c. Diazepam.?
d. Lidocaine.?
12. With prolonged use in seizure states, which of the following drugs can cause
coarsening of facial features, hirsutism, gingival hyperplasia and osteomalacia?
a. Valproic?acid.?
b. Carbamazepine.?
c. Ethosuximide.?
d. Phenytoin.?
?
13. Only Aspirin can:
a. Reduce?fever.?
b. Irreversible?inhibit?its?target?enzyme.?
c. Prevent?episodes?of?gouty?arthritis?with?long?term?use.?
d. Reduce?the?risk?of?colo?n? cancer.?
14. Indomethacin is preferred over Colchicine for Acute Attack of Gout because it is:
a. Less?likely?to?cause?gastrointestinal?bleeding.?
b. Less?likely?to?cause?diarrhea.?
c. Less?likely?to?cause?acute?renal?failure.?
d. More?likely?to?reduce?inflammation.?
15. Which of the following drugs is used in the treatment of rheumatoid arthritis?
a. Naproxen.?
b. Allopurinol.?
c. Colchicine.?
d. Sulfinpyrazone.?
16. The most dangerous adverse effect by using Fentanyl patches is:
a. Diarrhea.?
b. Relaxation?of?respiratory?muscles.?
c. Hypertension.?
d. Respiratory?depression.?
17. Morphine should be used with extreme caution in all of the following conditions
but not in:
a. Biliary?tract?surgery.?
b. Pulmonary?edema.?
c. Last?stage?of?labor.?
d. Hypothyroidism.?
18. A 35 year old patient complaining of severe pain along the right side of the jaw
and face; the best choice for this neuralgic pain is:
a. Methadone.?
b. Ibuprofen.?
c. Carbamazepine.?
d. Lorazepam.?
19. Which of the following local anesthetics is used exclusively for its good surface
activity and low toxic potential:
a. Cocaine.?
b. Benzocaine.?
c. Bupivacaine.?
d. Procaine.?
20. Which of the following drugs can cause methemoglobinemia when used in
larger doses for regional anesthesia?
a. Cocaine.?
b. Lidocaine.?
FirstRanker.com - FirstRanker's Choice
Hemwati Nandan Bahuguna Uttarakhand Medical
Education University?
Administrative?Block,?Govt.?Doon?Medical?College?Campus,?Dehrakhas,??
Patel?Nagar,?Dehradun???248001?
Phone:?0135???2723323?Fax:? 0135???2723323?
Website: www.hnbumu.ac.in? E?mail:?info.hnbumu@gmail.com
?
?
Ph.D. ENTRANCE EXAMINATION - 2020
?
?
Subject? :??Pharmacology? ? ??????????? Duration:?01:30?Hrs.?
Date?? :??06.01.2020? ? ??????????? Place?:?Dehradun?
Max?Marks:?60?? ?
?
?
?
?
?
?
?
Student?Name:??????Invigilator?Name:??
?
Signature:???????Signature:?
01. The steady-state concentration of a drug can be double by:
a. Doubling?the?both?rate?of?infusion?and?concentration?of? drug.?
b. Doubling?the?rate?of?infusion?only.?
c. Doubling?the?loading?dose?but?maintaining?the?infusion? rate.?
d. Tripling?the?rate?of?infusion.?
02. Phase II reactions of a drug biotransformation:
a. Decreases?its?water?solubility.?
b. Includes?activity?of?cytochrom?P?450.?
c. Usually?leads?to?inactivation?of?the?drug.?
d. Does?not?include?acetylation.?
03. Half-life of a drug may be helpful to determine:
a. Dosage?schedule?of?the?drug.?
b. Level?of?absorption.?
c. Distribution?into?different?body?systems.?
d. Time?to?get?the?steady?state.?
04. A 3 year old child has been admitted to emergency with suspicious of atropine
overdose as there are:
a. Abdominal?cramps.?
b. Increased?gastric?secretion.?
c. Increased?cardiac?rate.?
d. Papillary?constriction.?
?
05. Epinephrine does not cause increase concentrations of:
a. Glucose?in?blood.?
b. Lactate?in?blood.?
c. Free?fatty?acids?in?blood.?
d. Triglycerides?in?fat?cells.?
?
06. A 50 year old patient is having propranolol due to his cardiac problems but his
physician now wants to stop this drug; which of the following is the most
important reason for this step?
a. Familial?tremor.?
b. Partial?AV?heart?block.?
c. Mild?hypertension.?
d. Angina?pectoris.?
07. A young man of 24 years is suffering from Generalized Anxiety Disorder; which
drug may be preferred for his problem?
a. Zolpidem.?
b. Buspiron.?
c. Midazolam.?
d. Triazolam.?
08. Which of the following statements best describes the
mechanism of action of benzodiazepines?
a. Benzodiazepines?activate?GABA
B?
?receptors?in?the?spinal?cord.?
b. They?inhibit?GABA?transaminase?leading?to?increased?levels?of?GABA.?
c. They?block?glutamate?receptors??in?hierarchical?neuronal?pathways?in?the?brain.?
d. Benzodiazepines? increase? the? frequency? of? Cl
??
?channels?opening?which?are?
coupled?to?GABA
A?
receptors.?
09. Which of the following drugs when used for prolonged period in the
maintenance treatment of tonic-clonic seizures can lead to increased
metabolism of warfarin like drugs?
a. Phenobarbital.?
b. Meprobamate.?
c. Chlordiazepoxide.?
d. Triazolam.?
?
10. Characteristics of non-depolarizing neuromuscular blockade include which of
the following?
a. Block?of?post?tetanic?potentiation.?
b. Histamine?blocking?action.?
c. Poorly?sustained?tetanic?tension.?
d. Significant?muscle?fasciculations?during?onset?of?block.?
11. Which of the following drugs given preoperatively is used to prevent
postoperative pain caused by succinylcholine?
a. Dantrolene.?
b. Tubocurarine.?
c. Diazepam.?
d. Lidocaine.?
12. With prolonged use in seizure states, which of the following drugs can cause
coarsening of facial features, hirsutism, gingival hyperplasia and osteomalacia?
a. Valproic?acid.?
b. Carbamazepine.?
c. Ethosuximide.?
d. Phenytoin.?
?
13. Only Aspirin can:
a. Reduce?fever.?
b. Irreversible?inhibit?its?target?enzyme.?
c. Prevent?episodes?of?gouty?arthritis?with?long?term?use.?
d. Reduce?the?risk?of?colo?n? cancer.?
14. Indomethacin is preferred over Colchicine for Acute Attack of Gout because it is:
a. Less?likely?to?cause?gastrointestinal?bleeding.?
b. Less?likely?to?cause?diarrhea.?
c. Less?likely?to?cause?acute?renal?failure.?
d. More?likely?to?reduce?inflammation.?
15. Which of the following drugs is used in the treatment of rheumatoid arthritis?
a. Naproxen.?
b. Allopurinol.?
c. Colchicine.?
d. Sulfinpyrazone.?
16. The most dangerous adverse effect by using Fentanyl patches is:
a. Diarrhea.?
b. Relaxation?of?respiratory?muscles.?
c. Hypertension.?
d. Respiratory?depression.?
17. Morphine should be used with extreme caution in all of the following conditions
but not in:
a. Biliary?tract?surgery.?
b. Pulmonary?edema.?
c. Last?stage?of?labor.?
d. Hypothyroidism.?
18. A 35 year old patient complaining of severe pain along the right side of the jaw
and face; the best choice for this neuralgic pain is:
a. Methadone.?
b. Ibuprofen.?
c. Carbamazepine.?
d. Lorazepam.?
19. Which of the following local anesthetics is used exclusively for its good surface
activity and low toxic potential:
a. Cocaine.?
b. Benzocaine.?
c. Bupivacaine.?
d. Procaine.?
20. Which of the following drugs can cause methemoglobinemia when used in
larger doses for regional anesthesia?
a. Cocaine.?
b. Lidocaine.?
c. Bupivacaine.?
d. Prilocaine.?
21. Epinephrine added to a solution of lidocaine for local
anesthesia will:
a. Cause?cyanosis?locally.?
b. Increase?the?risk?of?convulsions.?
c. Increase?the?duration?of?local?anesthesia.?
d. Increase?the?absorption?of?lidocaine.?
22. Which of the following inhalational anesthetic agents is having fastest onset of
action?
a. Nitric?oxide.?
b. Isoflurane.?
c. Nitrous?oxide.?
d. Enflurane.?
23. To attempt reduction of a dislocated shoulder joint when Ketamine is used alone
it will ccause:
a. Respiratory?depression.?
b. Skeletal?muscle?rigidity.?
c. Hypotension.?
d. Analgesia.?
?
24. Which of the following drugs produces respiratory depression and so reversed
by flumazenil?
a. Fentanyl.?
b. Propofol.?
c. Ketamine.?
d. Midazolam.?
?
25. Cephalosporins show their antimicrobial action by:
a. Binding?to?cytoplasmic?receptor?proteins.?
b. Inhibition?of?beta?lactamases.?
c. Inhibition?of?transpeptidation?reactions.?
d. Interference?with?the?synthesis?of?ergosterol.?
26. The most appropriate drug regimen for empiric treatment of Gram-negative
bacilli in blood is:
a. Ampicillin?plus?sulbactam.?
b. Aztreonam.?
c. Cefazolin.?
d. Imipenem?plus?cilastatin.?
FirstRanker.com - FirstRanker's Choice
Hemwati Nandan Bahuguna Uttarakhand Medical
Education University?
Administrative?Block,?Govt.?Doon?Medical?College?Campus,?Dehrakhas,??
Patel?Nagar,?Dehradun???248001?
Phone:?0135???2723323?Fax:? 0135???2723323?
Website: www.hnbumu.ac.in? E?mail:?info.hnbumu@gmail.com
?
?
Ph.D. ENTRANCE EXAMINATION - 2020
?
?
Subject? :??Pharmacology? ? ??????????? Duration:?01:30?Hrs.?
Date?? :??06.01.2020? ? ??????????? Place?:?Dehradun?
Max?Marks:?60?? ?
?
?
?
?
?
?
?
Student?Name:??????Invigilator?Name:??
?
Signature:???????Signature:?
01. The steady-state concentration of a drug can be double by:
a. Doubling?the?both?rate?of?infusion?and?concentration?of? drug.?
b. Doubling?the?rate?of?infusion?only.?
c. Doubling?the?loading?dose?but?maintaining?the?infusion? rate.?
d. Tripling?the?rate?of?infusion.?
02. Phase II reactions of a drug biotransformation:
a. Decreases?its?water?solubility.?
b. Includes?activity?of?cytochrom?P?450.?
c. Usually?leads?to?inactivation?of?the?drug.?
d. Does?not?include?acetylation.?
03. Half-life of a drug may be helpful to determine:
a. Dosage?schedule?of?the?drug.?
b. Level?of?absorption.?
c. Distribution?into?different?body?systems.?
d. Time?to?get?the?steady?state.?
04. A 3 year old child has been admitted to emergency with suspicious of atropine
overdose as there are:
a. Abdominal?cramps.?
b. Increased?gastric?secretion.?
c. Increased?cardiac?rate.?
d. Papillary?constriction.?
?
05. Epinephrine does not cause increase concentrations of:
a. Glucose?in?blood.?
b. Lactate?in?blood.?
c. Free?fatty?acids?in?blood.?
d. Triglycerides?in?fat?cells.?
?
06. A 50 year old patient is having propranolol due to his cardiac problems but his
physician now wants to stop this drug; which of the following is the most
important reason for this step?
a. Familial?tremor.?
b. Partial?AV?heart?block.?
c. Mild?hypertension.?
d. Angina?pectoris.?
07. A young man of 24 years is suffering from Generalized Anxiety Disorder; which
drug may be preferred for his problem?
a. Zolpidem.?
b. Buspiron.?
c. Midazolam.?
d. Triazolam.?
08. Which of the following statements best describes the
mechanism of action of benzodiazepines?
a. Benzodiazepines?activate?GABA
B?
?receptors?in?the?spinal?cord.?
b. They?inhibit?GABA?transaminase?leading?to?increased?levels?of?GABA.?
c. They?block?glutamate?receptors??in?hierarchical?neuronal?pathways?in?the?brain.?
d. Benzodiazepines? increase? the? frequency? of? Cl
??
?channels?opening?which?are?
coupled?to?GABA
A?
receptors.?
09. Which of the following drugs when used for prolonged period in the
maintenance treatment of tonic-clonic seizures can lead to increased
metabolism of warfarin like drugs?
a. Phenobarbital.?
b. Meprobamate.?
c. Chlordiazepoxide.?
d. Triazolam.?
?
10. Characteristics of non-depolarizing neuromuscular blockade include which of
the following?
a. Block?of?post?tetanic?potentiation.?
b. Histamine?blocking?action.?
c. Poorly?sustained?tetanic?tension.?
d. Significant?muscle?fasciculations?during?onset?of?block.?
11. Which of the following drugs given preoperatively is used to prevent
postoperative pain caused by succinylcholine?
a. Dantrolene.?
b. Tubocurarine.?
c. Diazepam.?
d. Lidocaine.?
12. With prolonged use in seizure states, which of the following drugs can cause
coarsening of facial features, hirsutism, gingival hyperplasia and osteomalacia?
a. Valproic?acid.?
b. Carbamazepine.?
c. Ethosuximide.?
d. Phenytoin.?
?
13. Only Aspirin can:
a. Reduce?fever.?
b. Irreversible?inhibit?its?target?enzyme.?
c. Prevent?episodes?of?gouty?arthritis?with?long?term?use.?
d. Reduce?the?risk?of?colo?n? cancer.?
14. Indomethacin is preferred over Colchicine for Acute Attack of Gout because it is:
a. Less?likely?to?cause?gastrointestinal?bleeding.?
b. Less?likely?to?cause?diarrhea.?
c. Less?likely?to?cause?acute?renal?failure.?
d. More?likely?to?reduce?inflammation.?
15. Which of the following drugs is used in the treatment of rheumatoid arthritis?
a. Naproxen.?
b. Allopurinol.?
c. Colchicine.?
d. Sulfinpyrazone.?
16. The most dangerous adverse effect by using Fentanyl patches is:
a. Diarrhea.?
b. Relaxation?of?respiratory?muscles.?
c. Hypertension.?
d. Respiratory?depression.?
17. Morphine should be used with extreme caution in all of the following conditions
but not in:
a. Biliary?tract?surgery.?
b. Pulmonary?edema.?
c. Last?stage?of?labor.?
d. Hypothyroidism.?
18. A 35 year old patient complaining of severe pain along the right side of the jaw
and face; the best choice for this neuralgic pain is:
a. Methadone.?
b. Ibuprofen.?
c. Carbamazepine.?
d. Lorazepam.?
19. Which of the following local anesthetics is used exclusively for its good surface
activity and low toxic potential:
a. Cocaine.?
b. Benzocaine.?
c. Bupivacaine.?
d. Procaine.?
20. Which of the following drugs can cause methemoglobinemia when used in
larger doses for regional anesthesia?
a. Cocaine.?
b. Lidocaine.?
c. Bupivacaine.?
d. Prilocaine.?
21. Epinephrine added to a solution of lidocaine for local
anesthesia will:
a. Cause?cyanosis?locally.?
b. Increase?the?risk?of?convulsions.?
c. Increase?the?duration?of?local?anesthesia.?
d. Increase?the?absorption?of?lidocaine.?
22. Which of the following inhalational anesthetic agents is having fastest onset of
action?
a. Nitric?oxide.?
b. Isoflurane.?
c. Nitrous?oxide.?
d. Enflurane.?
23. To attempt reduction of a dislocated shoulder joint when Ketamine is used alone
it will ccause:
a. Respiratory?depression.?
b. Skeletal?muscle?rigidity.?
c. Hypotension.?
d. Analgesia.?
?
24. Which of the following drugs produces respiratory depression and so reversed
by flumazenil?
a. Fentanyl.?
b. Propofol.?
c. Ketamine.?
d. Midazolam.?
?
25. Cephalosporins show their antimicrobial action by:
a. Binding?to?cytoplasmic?receptor?proteins.?
b. Inhibition?of?beta?lactamases.?
c. Inhibition?of?transpeptidation?reactions.?
d. Interference?with?the?synthesis?of?ergosterol.?
26. The most appropriate drug regimen for empiric treatment of Gram-negative
bacilli in blood is:
a. Ampicillin?plus?sulbactam.?
b. Aztreonam.?
c. Cefazolin.?
d. Imipenem?plus?cilastatin.?
27. A BDS student while answering the question about ciprofloxacin gave various
statements; which of the following statements was rejected by the examiner?
a. Clinical?antagonism?occurs?when?used?with?Co?trimoxazole.?
b. Post?antibiotic?effects?are?similar?to?aminoglycosides.?
c. It?is?active?against?most?of?the?middle?ear?infecting? organisms.?
d. It?may?be?used?for?urinary?tract?infection.?
?
28. The mechanism underlying the resistance of G +ve organisms to macrolides is:
a. Decreased?drug?permeability?of?the?cytoplasmic?membrane.?
b. Methylation?of?binding?sites?on?the?50?S?ribosomal? subunit.?
c. Decreased?activity?of?uptake?mechanism.?
d. Formation?of?estrases?that?hydrolyze?the?lactone?ring.?
29. Doxycycline is:
a. Bactericidal.?
b. Not?excreted?in?the?feces.?
c. Having?a?short?elimination?half?life.?
d. Not?as?effective?as?tetracycline?against?H.pylori.?
30. Neomycin, an aminoglycoside is:
a. Least?nephrotoxic.?
b. Metabolized?by?hepatic?enzyme.?
c. Used?in?hepatic?coma.?
d. A?drug?of?choice?in?Rockey?Mountain?Spotted?fever.?
?
31. The toxic effect of amphotericin B which definitely require reduction of dose is:
a. Myelosuppression.?
b. Hepatitis.?
c. Renal?Toxicity.?
d. Hypotension.?
32. Which of the followings is useful topically for genital herpes infection?
a. Acyclovir.?
b. Amantadine.?
c. Ritonavir.?
d. Trifluridine.?
33. Acute hemorrhage cystitis is a common toxic effect seen with:
a. Vincristine.?
b. Tamoxifen.?
FirstRanker.com - FirstRanker's Choice
Hemwati Nandan Bahuguna Uttarakhand Medical
Education University?
Administrative?Block,?Govt.?Doon?Medical?College?Campus,?Dehrakhas,??
Patel?Nagar,?Dehradun???248001?
Phone:?0135???2723323?Fax:? 0135???2723323?
Website: www.hnbumu.ac.in? E?mail:?info.hnbumu@gmail.com
?
?
Ph.D. ENTRANCE EXAMINATION - 2020
?
?
Subject? :??Pharmacology? ? ??????????? Duration:?01:30?Hrs.?
Date?? :??06.01.2020? ? ??????????? Place?:?Dehradun?
Max?Marks:?60?? ?
?
?
?
?
?
?
?
Student?Name:??????Invigilator?Name:??
?
Signature:???????Signature:?
01. The steady-state concentration of a drug can be double by:
a. Doubling?the?both?rate?of?infusion?and?concentration?of? drug.?
b. Doubling?the?rate?of?infusion?only.?
c. Doubling?the?loading?dose?but?maintaining?the?infusion? rate.?
d. Tripling?the?rate?of?infusion.?
02. Phase II reactions of a drug biotransformation:
a. Decreases?its?water?solubility.?
b. Includes?activity?of?cytochrom?P?450.?
c. Usually?leads?to?inactivation?of?the?drug.?
d. Does?not?include?acetylation.?
03. Half-life of a drug may be helpful to determine:
a. Dosage?schedule?of?the?drug.?
b. Level?of?absorption.?
c. Distribution?into?different?body?systems.?
d. Time?to?get?the?steady?state.?
04. A 3 year old child has been admitted to emergency with suspicious of atropine
overdose as there are:
a. Abdominal?cramps.?
b. Increased?gastric?secretion.?
c. Increased?cardiac?rate.?
d. Papillary?constriction.?
?
05. Epinephrine does not cause increase concentrations of:
a. Glucose?in?blood.?
b. Lactate?in?blood.?
c. Free?fatty?acids?in?blood.?
d. Triglycerides?in?fat?cells.?
?
06. A 50 year old patient is having propranolol due to his cardiac problems but his
physician now wants to stop this drug; which of the following is the most
important reason for this step?
a. Familial?tremor.?
b. Partial?AV?heart?block.?
c. Mild?hypertension.?
d. Angina?pectoris.?
07. A young man of 24 years is suffering from Generalized Anxiety Disorder; which
drug may be preferred for his problem?
a. Zolpidem.?
b. Buspiron.?
c. Midazolam.?
d. Triazolam.?
08. Which of the following statements best describes the
mechanism of action of benzodiazepines?
a. Benzodiazepines?activate?GABA
B?
?receptors?in?the?spinal?cord.?
b. They?inhibit?GABA?transaminase?leading?to?increased?levels?of?GABA.?
c. They?block?glutamate?receptors??in?hierarchical?neuronal?pathways?in?the?brain.?
d. Benzodiazepines? increase? the? frequency? of? Cl
??
?channels?opening?which?are?
coupled?to?GABA
A?
receptors.?
09. Which of the following drugs when used for prolonged period in the
maintenance treatment of tonic-clonic seizures can lead to increased
metabolism of warfarin like drugs?
a. Phenobarbital.?
b. Meprobamate.?
c. Chlordiazepoxide.?
d. Triazolam.?
?
10. Characteristics of non-depolarizing neuromuscular blockade include which of
the following?
a. Block?of?post?tetanic?potentiation.?
b. Histamine?blocking?action.?
c. Poorly?sustained?tetanic?tension.?
d. Significant?muscle?fasciculations?during?onset?of?block.?
11. Which of the following drugs given preoperatively is used to prevent
postoperative pain caused by succinylcholine?
a. Dantrolene.?
b. Tubocurarine.?
c. Diazepam.?
d. Lidocaine.?
12. With prolonged use in seizure states, which of the following drugs can cause
coarsening of facial features, hirsutism, gingival hyperplasia and osteomalacia?
a. Valproic?acid.?
b. Carbamazepine.?
c. Ethosuximide.?
d. Phenytoin.?
?
13. Only Aspirin can:
a. Reduce?fever.?
b. Irreversible?inhibit?its?target?enzyme.?
c. Prevent?episodes?of?gouty?arthritis?with?long?term?use.?
d. Reduce?the?risk?of?colo?n? cancer.?
14. Indomethacin is preferred over Colchicine for Acute Attack of Gout because it is:
a. Less?likely?to?cause?gastrointestinal?bleeding.?
b. Less?likely?to?cause?diarrhea.?
c. Less?likely?to?cause?acute?renal?failure.?
d. More?likely?to?reduce?inflammation.?
15. Which of the following drugs is used in the treatment of rheumatoid arthritis?
a. Naproxen.?
b. Allopurinol.?
c. Colchicine.?
d. Sulfinpyrazone.?
16. The most dangerous adverse effect by using Fentanyl patches is:
a. Diarrhea.?
b. Relaxation?of?respiratory?muscles.?
c. Hypertension.?
d. Respiratory?depression.?
17. Morphine should be used with extreme caution in all of the following conditions
but not in:
a. Biliary?tract?surgery.?
b. Pulmonary?edema.?
c. Last?stage?of?labor.?
d. Hypothyroidism.?
18. A 35 year old patient complaining of severe pain along the right side of the jaw
and face; the best choice for this neuralgic pain is:
a. Methadone.?
b. Ibuprofen.?
c. Carbamazepine.?
d. Lorazepam.?
19. Which of the following local anesthetics is used exclusively for its good surface
activity and low toxic potential:
a. Cocaine.?
b. Benzocaine.?
c. Bupivacaine.?
d. Procaine.?
20. Which of the following drugs can cause methemoglobinemia when used in
larger doses for regional anesthesia?
a. Cocaine.?
b. Lidocaine.?
c. Bupivacaine.?
d. Prilocaine.?
21. Epinephrine added to a solution of lidocaine for local
anesthesia will:
a. Cause?cyanosis?locally.?
b. Increase?the?risk?of?convulsions.?
c. Increase?the?duration?of?local?anesthesia.?
d. Increase?the?absorption?of?lidocaine.?
22. Which of the following inhalational anesthetic agents is having fastest onset of
action?
a. Nitric?oxide.?
b. Isoflurane.?
c. Nitrous?oxide.?
d. Enflurane.?
23. To attempt reduction of a dislocated shoulder joint when Ketamine is used alone
it will ccause:
a. Respiratory?depression.?
b. Skeletal?muscle?rigidity.?
c. Hypotension.?
d. Analgesia.?
?
24. Which of the following drugs produces respiratory depression and so reversed
by flumazenil?
a. Fentanyl.?
b. Propofol.?
c. Ketamine.?
d. Midazolam.?
?
25. Cephalosporins show their antimicrobial action by:
a. Binding?to?cytoplasmic?receptor?proteins.?
b. Inhibition?of?beta?lactamases.?
c. Inhibition?of?transpeptidation?reactions.?
d. Interference?with?the?synthesis?of?ergosterol.?
26. The most appropriate drug regimen for empiric treatment of Gram-negative
bacilli in blood is:
a. Ampicillin?plus?sulbactam.?
b. Aztreonam.?
c. Cefazolin.?
d. Imipenem?plus?cilastatin.?
27. A BDS student while answering the question about ciprofloxacin gave various
statements; which of the following statements was rejected by the examiner?
a. Clinical?antagonism?occurs?when?used?with?Co?trimoxazole.?
b. Post?antibiotic?effects?are?similar?to?aminoglycosides.?
c. It?is?active?against?most?of?the?middle?ear?infecting? organisms.?
d. It?may?be?used?for?urinary?tract?infection.?
?
28. The mechanism underlying the resistance of G +ve organisms to macrolides is:
a. Decreased?drug?permeability?of?the?cytoplasmic?membrane.?
b. Methylation?of?binding?sites?on?the?50?S?ribosomal? subunit.?
c. Decreased?activity?of?uptake?mechanism.?
d. Formation?of?estrases?that?hydrolyze?the?lactone?ring.?
29. Doxycycline is:
a. Bactericidal.?
b. Not?excreted?in?the?feces.?
c. Having?a?short?elimination?half?life.?
d. Not?as?effective?as?tetracycline?against?H.pylori.?
30. Neomycin, an aminoglycoside is:
a. Least?nephrotoxic.?
b. Metabolized?by?hepatic?enzyme.?
c. Used?in?hepatic?coma.?
d. A?drug?of?choice?in?Rockey?Mountain?Spotted?fever.?
?
31. The toxic effect of amphotericin B which definitely require reduction of dose is:
a. Myelosuppression.?
b. Hepatitis.?
c. Renal?Toxicity.?
d. Hypotension.?
32. Which of the followings is useful topically for genital herpes infection?
a. Acyclovir.?
b. Amantadine.?
c. Ritonavir.?
d. Trifluridine.?
33. Acute hemorrhage cystitis is a common toxic effect seen with:
a. Vincristine.?
b. Tamoxifen.?
c. Doxorubicin.?
d. Cyclophosphamide.?
34. A young girl of 20 years has taken a suicidal overdose of Digoxin, the drug of
choice in her treatment will be:
a. Lidocaine.?
b. Phenytoin.?
c. Digoxin? antibodies.?
d. Potassium? chloride.?
35. A 45 year old patient developed severe thrombocytopenia due to unfractionated
heparin so the best alternative anticoagulant will be:
a. Lepirudin.?
b. Abciximab.?
c. Urokinase.?
d. Plasminogen.?
36. A 30 year old male suffering from cerebral edema will be best treated with:
a. Furosemide.?
b. Amiloride.?
c. Ethacrynic?acid.?
d. Mannitol.?
e. Acetazolamide.?
?
37. While prescribing a treatment to a young female patient suffering from peptic
ulcer associated with H. Pylori the gastroenterologist will neglect:
a. Tetracycline.?
b. Vancomycin.?
c. Amoxicillin.?
d. Metronidazole.?
?
38. A 35 year old lady who is on anticancer therapy is now suffering from severe
nausea and vomiting; which of the following drugs is having most effective
antiemetic actions in this case?
a. Dexamethasone.?
b. Levodopa.?
c. Apomorphine.?
d. Sucrulfate.?
39. Which of the following is a prophylactic antiasthmetic agent that stabilizes mast
cells:
a. Ipratropium.?
b. Prednisone.?
c. Terbutaline.?
d. Cromolyn.?
FirstRanker.com - FirstRanker's Choice
Hemwati Nandan Bahuguna Uttarakhand Medical
Education University?
Administrative?Block,?Govt.?Doon?Medical?College?Campus,?Dehrakhas,??
Patel?Nagar,?Dehradun???248001?
Phone:?0135???2723323?Fax:? 0135???2723323?
Website: www.hnbumu.ac.in? E?mail:?info.hnbumu@gmail.com
?
?
Ph.D. ENTRANCE EXAMINATION - 2020
?
?
Subject? :??Pharmacology? ? ??????????? Duration:?01:30?Hrs.?
Date?? :??06.01.2020? ? ??????????? Place?:?Dehradun?
Max?Marks:?60?? ?
?
?
?
?
?
?
?
Student?Name:??????Invigilator?Name:??
?
Signature:???????Signature:?
01. The steady-state concentration of a drug can be double by:
a. Doubling?the?both?rate?of?infusion?and?concentration?of? drug.?
b. Doubling?the?rate?of?infusion?only.?
c. Doubling?the?loading?dose?but?maintaining?the?infusion? rate.?
d. Tripling?the?rate?of?infusion.?
02. Phase II reactions of a drug biotransformation:
a. Decreases?its?water?solubility.?
b. Includes?activity?of?cytochrom?P?450.?
c. Usually?leads?to?inactivation?of?the?drug.?
d. Does?not?include?acetylation.?
03. Half-life of a drug may be helpful to determine:
a. Dosage?schedule?of?the?drug.?
b. Level?of?absorption.?
c. Distribution?into?different?body?systems.?
d. Time?to?get?the?steady?state.?
04. A 3 year old child has been admitted to emergency with suspicious of atropine
overdose as there are:
a. Abdominal?cramps.?
b. Increased?gastric?secretion.?
c. Increased?cardiac?rate.?
d. Papillary?constriction.?
?
05. Epinephrine does not cause increase concentrations of:
a. Glucose?in?blood.?
b. Lactate?in?blood.?
c. Free?fatty?acids?in?blood.?
d. Triglycerides?in?fat?cells.?
?
06. A 50 year old patient is having propranolol due to his cardiac problems but his
physician now wants to stop this drug; which of the following is the most
important reason for this step?
a. Familial?tremor.?
b. Partial?AV?heart?block.?
c. Mild?hypertension.?
d. Angina?pectoris.?
07. A young man of 24 years is suffering from Generalized Anxiety Disorder; which
drug may be preferred for his problem?
a. Zolpidem.?
b. Buspiron.?
c. Midazolam.?
d. Triazolam.?
08. Which of the following statements best describes the
mechanism of action of benzodiazepines?
a. Benzodiazepines?activate?GABA
B?
?receptors?in?the?spinal?cord.?
b. They?inhibit?GABA?transaminase?leading?to?increased?levels?of?GABA.?
c. They?block?glutamate?receptors??in?hierarchical?neuronal?pathways?in?the?brain.?
d. Benzodiazepines? increase? the? frequency? of? Cl
??
?channels?opening?which?are?
coupled?to?GABA
A?
receptors.?
09. Which of the following drugs when used for prolonged period in the
maintenance treatment of tonic-clonic seizures can lead to increased
metabolism of warfarin like drugs?
a. Phenobarbital.?
b. Meprobamate.?
c. Chlordiazepoxide.?
d. Triazolam.?
?
10. Characteristics of non-depolarizing neuromuscular blockade include which of
the following?
a. Block?of?post?tetanic?potentiation.?
b. Histamine?blocking?action.?
c. Poorly?sustained?tetanic?tension.?
d. Significant?muscle?fasciculations?during?onset?of?block.?
11. Which of the following drugs given preoperatively is used to prevent
postoperative pain caused by succinylcholine?
a. Dantrolene.?
b. Tubocurarine.?
c. Diazepam.?
d. Lidocaine.?
12. With prolonged use in seizure states, which of the following drugs can cause
coarsening of facial features, hirsutism, gingival hyperplasia and osteomalacia?
a. Valproic?acid.?
b. Carbamazepine.?
c. Ethosuximide.?
d. Phenytoin.?
?
13. Only Aspirin can:
a. Reduce?fever.?
b. Irreversible?inhibit?its?target?enzyme.?
c. Prevent?episodes?of?gouty?arthritis?with?long?term?use.?
d. Reduce?the?risk?of?colo?n? cancer.?
14. Indomethacin is preferred over Colchicine for Acute Attack of Gout because it is:
a. Less?likely?to?cause?gastrointestinal?bleeding.?
b. Less?likely?to?cause?diarrhea.?
c. Less?likely?to?cause?acute?renal?failure.?
d. More?likely?to?reduce?inflammation.?
15. Which of the following drugs is used in the treatment of rheumatoid arthritis?
a. Naproxen.?
b. Allopurinol.?
c. Colchicine.?
d. Sulfinpyrazone.?
16. The most dangerous adverse effect by using Fentanyl patches is:
a. Diarrhea.?
b. Relaxation?of?respiratory?muscles.?
c. Hypertension.?
d. Respiratory?depression.?
17. Morphine should be used with extreme caution in all of the following conditions
but not in:
a. Biliary?tract?surgery.?
b. Pulmonary?edema.?
c. Last?stage?of?labor.?
d. Hypothyroidism.?
18. A 35 year old patient complaining of severe pain along the right side of the jaw
and face; the best choice for this neuralgic pain is:
a. Methadone.?
b. Ibuprofen.?
c. Carbamazepine.?
d. Lorazepam.?
19. Which of the following local anesthetics is used exclusively for its good surface
activity and low toxic potential:
a. Cocaine.?
b. Benzocaine.?
c. Bupivacaine.?
d. Procaine.?
20. Which of the following drugs can cause methemoglobinemia when used in
larger doses for regional anesthesia?
a. Cocaine.?
b. Lidocaine.?
c. Bupivacaine.?
d. Prilocaine.?
21. Epinephrine added to a solution of lidocaine for local
anesthesia will:
a. Cause?cyanosis?locally.?
b. Increase?the?risk?of?convulsions.?
c. Increase?the?duration?of?local?anesthesia.?
d. Increase?the?absorption?of?lidocaine.?
22. Which of the following inhalational anesthetic agents is having fastest onset of
action?
a. Nitric?oxide.?
b. Isoflurane.?
c. Nitrous?oxide.?
d. Enflurane.?
23. To attempt reduction of a dislocated shoulder joint when Ketamine is used alone
it will ccause:
a. Respiratory?depression.?
b. Skeletal?muscle?rigidity.?
c. Hypotension.?
d. Analgesia.?
?
24. Which of the following drugs produces respiratory depression and so reversed
by flumazenil?
a. Fentanyl.?
b. Propofol.?
c. Ketamine.?
d. Midazolam.?
?
25. Cephalosporins show their antimicrobial action by:
a. Binding?to?cytoplasmic?receptor?proteins.?
b. Inhibition?of?beta?lactamases.?
c. Inhibition?of?transpeptidation?reactions.?
d. Interference?with?the?synthesis?of?ergosterol.?
26. The most appropriate drug regimen for empiric treatment of Gram-negative
bacilli in blood is:
a. Ampicillin?plus?sulbactam.?
b. Aztreonam.?
c. Cefazolin.?
d. Imipenem?plus?cilastatin.?
27. A BDS student while answering the question about ciprofloxacin gave various
statements; which of the following statements was rejected by the examiner?
a. Clinical?antagonism?occurs?when?used?with?Co?trimoxazole.?
b. Post?antibiotic?effects?are?similar?to?aminoglycosides.?
c. It?is?active?against?most?of?the?middle?ear?infecting? organisms.?
d. It?may?be?used?for?urinary?tract?infection.?
?
28. The mechanism underlying the resistance of G +ve organisms to macrolides is:
a. Decreased?drug?permeability?of?the?cytoplasmic?membrane.?
b. Methylation?of?binding?sites?on?the?50?S?ribosomal? subunit.?
c. Decreased?activity?of?uptake?mechanism.?
d. Formation?of?estrases?that?hydrolyze?the?lactone?ring.?
29. Doxycycline is:
a. Bactericidal.?
b. Not?excreted?in?the?feces.?
c. Having?a?short?elimination?half?life.?
d. Not?as?effective?as?tetracycline?against?H.pylori.?
30. Neomycin, an aminoglycoside is:
a. Least?nephrotoxic.?
b. Metabolized?by?hepatic?enzyme.?
c. Used?in?hepatic?coma.?
d. A?drug?of?choice?in?Rockey?Mountain?Spotted?fever.?
?
31. The toxic effect of amphotericin B which definitely require reduction of dose is:
a. Myelosuppression.?
b. Hepatitis.?
c. Renal?Toxicity.?
d. Hypotension.?
32. Which of the followings is useful topically for genital herpes infection?
a. Acyclovir.?
b. Amantadine.?
c. Ritonavir.?
d. Trifluridine.?
33. Acute hemorrhage cystitis is a common toxic effect seen with:
a. Vincristine.?
b. Tamoxifen.?
c. Doxorubicin.?
d. Cyclophosphamide.?
34. A young girl of 20 years has taken a suicidal overdose of Digoxin, the drug of
choice in her treatment will be:
a. Lidocaine.?
b. Phenytoin.?
c. Digoxin? antibodies.?
d. Potassium? chloride.?
35. A 45 year old patient developed severe thrombocytopenia due to unfractionated
heparin so the best alternative anticoagulant will be:
a. Lepirudin.?
b. Abciximab.?
c. Urokinase.?
d. Plasminogen.?
36. A 30 year old male suffering from cerebral edema will be best treated with:
a. Furosemide.?
b. Amiloride.?
c. Ethacrynic?acid.?
d. Mannitol.?
e. Acetazolamide.?
?
37. While prescribing a treatment to a young female patient suffering from peptic
ulcer associated with H. Pylori the gastroenterologist will neglect:
a. Tetracycline.?
b. Vancomycin.?
c. Amoxicillin.?
d. Metronidazole.?
?
38. A 35 year old lady who is on anticancer therapy is now suffering from severe
nausea and vomiting; which of the following drugs is having most effective
antiemetic actions in this case?
a. Dexamethasone.?
b. Levodopa.?
c. Apomorphine.?
d. Sucrulfate.?
39. Which of the following is a prophylactic antiasthmetic agent that stabilizes mast
cells:
a. Ipratropium.?
b. Prednisone.?
c. Terbutaline.?
d. Cromolyn.?
40. A senior dental surgeon is very much concerned about the systemic effect of the
topically -used drugs for plaque prevention; which of the following drugs will
least be considered by him due to the same reason?
a. Vancomycin.?
b. Bacitracin.?
c. Polymyxin???B.?
d. Clarithromycin.?
41. Peppermint is least useful in:
a. Gingivitis? .?
b. Periodontitis? .?
c. Young?children.?
d. Dental?gum.?
42. Clove oil:
a. Can?not?be?used?as?temporary?filling?material.?
b. Has?no?anti?inflammatory?effect.?
c. Can?not?increase?bleeding?when?applied.?
d. Has?antifungal?activity?also.?
?
43. Eugenol when sealed in a root canal preparation leads to severe tissue damage:
a. Without?pain?as?it?has?analgesic?effect.?
b. Without?pain?as?it?has?local?anesthetic? effect.?
c. Because?it?has?corrosive?effect.?
d. With?local?bleeding?also.?
44. Which of the following statements is least related to
Chlorhexidine (0.2%)?
a. It?is?useful?in?reducing?plaque?formation.?
b. It?can?cause?staining?of?the?teeth.?
c. There?is?increased?formation?of?calculi.?
d. It?is?not?effective?in?gingivit?is.?
45. Which of the following statements is rarely seen with
Azadirachta Indica (Neem):
a. Can?be?used?in?toothpaste.?
b. Shows?antimicrobial?activity.?
c. Has?mild?abrasive?effects.?
d. Can?not?inhibit?plaque?formation.?
?
46. Most potent fluoroquinolone against Mycobacterium leprae is??
a.?Levofloxacin?
FirstRanker.com - FirstRanker's Choice
Hemwati Nandan Bahuguna Uttarakhand Medical
Education University?
Administrative?Block,?Govt.?Doon?Medical?College?Campus,?Dehrakhas,??
Patel?Nagar,?Dehradun???248001?
Phone:?0135???2723323?Fax:? 0135???2723323?
Website: www.hnbumu.ac.in? E?mail:?info.hnbumu@gmail.com
?
?
Ph.D. ENTRANCE EXAMINATION - 2020
?
?
Subject? :??Pharmacology? ? ??????????? Duration:?01:30?Hrs.?
Date?? :??06.01.2020? ? ??????????? Place?:?Dehradun?
Max?Marks:?60?? ?
?
?
?
?
?
?
?
Student?Name:??????Invigilator?Name:??
?
Signature:???????Signature:?
01. The steady-state concentration of a drug can be double by:
a. Doubling?the?both?rate?of?infusion?and?concentration?of? drug.?
b. Doubling?the?rate?of?infusion?only.?
c. Doubling?the?loading?dose?but?maintaining?the?infusion? rate.?
d. Tripling?the?rate?of?infusion.?
02. Phase II reactions of a drug biotransformation:
a. Decreases?its?water?solubility.?
b. Includes?activity?of?cytochrom?P?450.?
c. Usually?leads?to?inactivation?of?the?drug.?
d. Does?not?include?acetylation.?
03. Half-life of a drug may be helpful to determine:
a. Dosage?schedule?of?the?drug.?
b. Level?of?absorption.?
c. Distribution?into?different?body?systems.?
d. Time?to?get?the?steady?state.?
04. A 3 year old child has been admitted to emergency with suspicious of atropine
overdose as there are:
a. Abdominal?cramps.?
b. Increased?gastric?secretion.?
c. Increased?cardiac?rate.?
d. Papillary?constriction.?
?
05. Epinephrine does not cause increase concentrations of:
a. Glucose?in?blood.?
b. Lactate?in?blood.?
c. Free?fatty?acids?in?blood.?
d. Triglycerides?in?fat?cells.?
?
06. A 50 year old patient is having propranolol due to his cardiac problems but his
physician now wants to stop this drug; which of the following is the most
important reason for this step?
a. Familial?tremor.?
b. Partial?AV?heart?block.?
c. Mild?hypertension.?
d. Angina?pectoris.?
07. A young man of 24 years is suffering from Generalized Anxiety Disorder; which
drug may be preferred for his problem?
a. Zolpidem.?
b. Buspiron.?
c. Midazolam.?
d. Triazolam.?
08. Which of the following statements best describes the
mechanism of action of benzodiazepines?
a. Benzodiazepines?activate?GABA
B?
?receptors?in?the?spinal?cord.?
b. They?inhibit?GABA?transaminase?leading?to?increased?levels?of?GABA.?
c. They?block?glutamate?receptors??in?hierarchical?neuronal?pathways?in?the?brain.?
d. Benzodiazepines? increase? the? frequency? of? Cl
??
?channels?opening?which?are?
coupled?to?GABA
A?
receptors.?
09. Which of the following drugs when used for prolonged period in the
maintenance treatment of tonic-clonic seizures can lead to increased
metabolism of warfarin like drugs?
a. Phenobarbital.?
b. Meprobamate.?
c. Chlordiazepoxide.?
d. Triazolam.?
?
10. Characteristics of non-depolarizing neuromuscular blockade include which of
the following?
a. Block?of?post?tetanic?potentiation.?
b. Histamine?blocking?action.?
c. Poorly?sustained?tetanic?tension.?
d. Significant?muscle?fasciculations?during?onset?of?block.?
11. Which of the following drugs given preoperatively is used to prevent
postoperative pain caused by succinylcholine?
a. Dantrolene.?
b. Tubocurarine.?
c. Diazepam.?
d. Lidocaine.?
12. With prolonged use in seizure states, which of the following drugs can cause
coarsening of facial features, hirsutism, gingival hyperplasia and osteomalacia?
a. Valproic?acid.?
b. Carbamazepine.?
c. Ethosuximide.?
d. Phenytoin.?
?
13. Only Aspirin can:
a. Reduce?fever.?
b. Irreversible?inhibit?its?target?enzyme.?
c. Prevent?episodes?of?gouty?arthritis?with?long?term?use.?
d. Reduce?the?risk?of?colo?n? cancer.?
14. Indomethacin is preferred over Colchicine for Acute Attack of Gout because it is:
a. Less?likely?to?cause?gastrointestinal?bleeding.?
b. Less?likely?to?cause?diarrhea.?
c. Less?likely?to?cause?acute?renal?failure.?
d. More?likely?to?reduce?inflammation.?
15. Which of the following drugs is used in the treatment of rheumatoid arthritis?
a. Naproxen.?
b. Allopurinol.?
c. Colchicine.?
d. Sulfinpyrazone.?
16. The most dangerous adverse effect by using Fentanyl patches is:
a. Diarrhea.?
b. Relaxation?of?respiratory?muscles.?
c. Hypertension.?
d. Respiratory?depression.?
17. Morphine should be used with extreme caution in all of the following conditions
but not in:
a. Biliary?tract?surgery.?
b. Pulmonary?edema.?
c. Last?stage?of?labor.?
d. Hypothyroidism.?
18. A 35 year old patient complaining of severe pain along the right side of the jaw
and face; the best choice for this neuralgic pain is:
a. Methadone.?
b. Ibuprofen.?
c. Carbamazepine.?
d. Lorazepam.?
19. Which of the following local anesthetics is used exclusively for its good surface
activity and low toxic potential:
a. Cocaine.?
b. Benzocaine.?
c. Bupivacaine.?
d. Procaine.?
20. Which of the following drugs can cause methemoglobinemia when used in
larger doses for regional anesthesia?
a. Cocaine.?
b. Lidocaine.?
c. Bupivacaine.?
d. Prilocaine.?
21. Epinephrine added to a solution of lidocaine for local
anesthesia will:
a. Cause?cyanosis?locally.?
b. Increase?the?risk?of?convulsions.?
c. Increase?the?duration?of?local?anesthesia.?
d. Increase?the?absorption?of?lidocaine.?
22. Which of the following inhalational anesthetic agents is having fastest onset of
action?
a. Nitric?oxide.?
b. Isoflurane.?
c. Nitrous?oxide.?
d. Enflurane.?
23. To attempt reduction of a dislocated shoulder joint when Ketamine is used alone
it will ccause:
a. Respiratory?depression.?
b. Skeletal?muscle?rigidity.?
c. Hypotension.?
d. Analgesia.?
?
24. Which of the following drugs produces respiratory depression and so reversed
by flumazenil?
a. Fentanyl.?
b. Propofol.?
c. Ketamine.?
d. Midazolam.?
?
25. Cephalosporins show their antimicrobial action by:
a. Binding?to?cytoplasmic?receptor?proteins.?
b. Inhibition?of?beta?lactamases.?
c. Inhibition?of?transpeptidation?reactions.?
d. Interference?with?the?synthesis?of?ergosterol.?
26. The most appropriate drug regimen for empiric treatment of Gram-negative
bacilli in blood is:
a. Ampicillin?plus?sulbactam.?
b. Aztreonam.?
c. Cefazolin.?
d. Imipenem?plus?cilastatin.?
27. A BDS student while answering the question about ciprofloxacin gave various
statements; which of the following statements was rejected by the examiner?
a. Clinical?antagonism?occurs?when?used?with?Co?trimoxazole.?
b. Post?antibiotic?effects?are?similar?to?aminoglycosides.?
c. It?is?active?against?most?of?the?middle?ear?infecting? organisms.?
d. It?may?be?used?for?urinary?tract?infection.?
?
28. The mechanism underlying the resistance of G +ve organisms to macrolides is:
a. Decreased?drug?permeability?of?the?cytoplasmic?membrane.?
b. Methylation?of?binding?sites?on?the?50?S?ribosomal? subunit.?
c. Decreased?activity?of?uptake?mechanism.?
d. Formation?of?estrases?that?hydrolyze?the?lactone?ring.?
29. Doxycycline is:
a. Bactericidal.?
b. Not?excreted?in?the?feces.?
c. Having?a?short?elimination?half?life.?
d. Not?as?effective?as?tetracycline?against?H.pylori.?
30. Neomycin, an aminoglycoside is:
a. Least?nephrotoxic.?
b. Metabolized?by?hepatic?enzyme.?
c. Used?in?hepatic?coma.?
d. A?drug?of?choice?in?Rockey?Mountain?Spotted?fever.?
?
31. The toxic effect of amphotericin B which definitely require reduction of dose is:
a. Myelosuppression.?
b. Hepatitis.?
c. Renal?Toxicity.?
d. Hypotension.?
32. Which of the followings is useful topically for genital herpes infection?
a. Acyclovir.?
b. Amantadine.?
c. Ritonavir.?
d. Trifluridine.?
33. Acute hemorrhage cystitis is a common toxic effect seen with:
a. Vincristine.?
b. Tamoxifen.?
c. Doxorubicin.?
d. Cyclophosphamide.?
34. A young girl of 20 years has taken a suicidal overdose of Digoxin, the drug of
choice in her treatment will be:
a. Lidocaine.?
b. Phenytoin.?
c. Digoxin? antibodies.?
d. Potassium? chloride.?
35. A 45 year old patient developed severe thrombocytopenia due to unfractionated
heparin so the best alternative anticoagulant will be:
a. Lepirudin.?
b. Abciximab.?
c. Urokinase.?
d. Plasminogen.?
36. A 30 year old male suffering from cerebral edema will be best treated with:
a. Furosemide.?
b. Amiloride.?
c. Ethacrynic?acid.?
d. Mannitol.?
e. Acetazolamide.?
?
37. While prescribing a treatment to a young female patient suffering from peptic
ulcer associated with H. Pylori the gastroenterologist will neglect:
a. Tetracycline.?
b. Vancomycin.?
c. Amoxicillin.?
d. Metronidazole.?
?
38. A 35 year old lady who is on anticancer therapy is now suffering from severe
nausea and vomiting; which of the following drugs is having most effective
antiemetic actions in this case?
a. Dexamethasone.?
b. Levodopa.?
c. Apomorphine.?
d. Sucrulfate.?
39. Which of the following is a prophylactic antiasthmetic agent that stabilizes mast
cells:
a. Ipratropium.?
b. Prednisone.?
c. Terbutaline.?
d. Cromolyn.?
40. A senior dental surgeon is very much concerned about the systemic effect of the
topically -used drugs for plaque prevention; which of the following drugs will
least be considered by him due to the same reason?
a. Vancomycin.?
b. Bacitracin.?
c. Polymyxin???B.?
d. Clarithromycin.?
41. Peppermint is least useful in:
a. Gingivitis? .?
b. Periodontitis? .?
c. Young?children.?
d. Dental?gum.?
42. Clove oil:
a. Can?not?be?used?as?temporary?filling?material.?
b. Has?no?anti?inflammatory?effect.?
c. Can?not?increase?bleeding?when?applied.?
d. Has?antifungal?activity?also.?
?
43. Eugenol when sealed in a root canal preparation leads to severe tissue damage:
a. Without?pain?as?it?has?analgesic?effect.?
b. Without?pain?as?it?has?local?anesthetic? effect.?
c. Because?it?has?corrosive?effect.?
d. With?local?bleeding?also.?
44. Which of the following statements is least related to
Chlorhexidine (0.2%)?
a. It?is?useful?in?reducing?plaque?formation.?
b. It?can?cause?staining?of?the?teeth.?
c. There?is?increased?formation?of?calculi.?
d. It?is?not?effective?in?gingivit?is.?
45. Which of the following statements is rarely seen with
Azadirachta Indica (Neem):
a. Can?be?used?in?toothpaste.?
b. Shows?antimicrobial?activity.?
c. Has?mild?abrasive?effects.?
d. Can?not?inhibit?plaque?formation.?
?
46. Most potent fluoroquinolone against Mycobacterium leprae is??
a.?Levofloxacin?
b.?Ofloxacin?
c.?Moxifloxacin?
d.?Ciprofloxacin?
47. The antiretroviral drug combination to be avoided is??
a.?Zidovudine?+?Stavudine?
b.?Zidovudine?+?Lamivudine?
c.?Didanosine?+?Abacavir?
d.?Didanosine?+?Zidovudine?
?
48. Shortest acting non benzodiazepine hypnotic is??
a.?Zaleplon?
b.?Zolpidem?
c.?Zopiclone?
d.?Eszopiclone?
?
49. Which of the following is true regarding Drotaverine??
a.?M3?selective?muscarinic?antagonist?
b.?Causes?smooth?muscle?contraction?
c.?Causes?anticholinergic?side?effects?
d.?Inhibits?phosphodiesterase?4?
?
50. Which is associated with vaginal carcinoma in female offspring??
a.?Diethylstilbestrol?
b.?Phenytoin?
c.?ACE?inhibitors?
d.?Indomethacin?
51. Which of the following is not an action of muscarinic antagonists??
a.?Reduce?respiratory?secretions?
b.?Reduce?gastric?secretions?
c.?Contraction?of?radial?muscles?of?iris?
d.?Increase?rate?of?conduction?in?the?heart?
52. Which of the following is not a long acting muscarinic antagonist?
a.?Glycopyrronium?
b.?Aclidinium?
c.?Indacaterol?
d.?Umeclidinium?
?
53. Most potent fluoroquinolone against Mycobacterium leprae is?
a.?Levofloxacin?
b.?Ofloxacin?
c.?Moxifloxacin?
d.?Ciprofloxacin?
?
54. Which of the following is not related to a drug toxicity of Atenolol??
a. CHF??
b. Tachycardia??
FirstRanker.com - FirstRanker's Choice
Hemwati Nandan Bahuguna Uttarakhand Medical
Education University?
Administrative?Block,?Govt.?Doon?Medical?College?Campus,?Dehrakhas,??
Patel?Nagar,?Dehradun???248001?
Phone:?0135???2723323?Fax:? 0135???2723323?
Website: www.hnbumu.ac.in? E?mail:?info.hnbumu@gmail.com
?
?
Ph.D. ENTRANCE EXAMINATION - 2020
?
?
Subject? :??Pharmacology? ? ??????????? Duration:?01:30?Hrs.?
Date?? :??06.01.2020? ? ??????????? Place?:?Dehradun?
Max?Marks:?60?? ?
?
?
?
?
?
?
?
Student?Name:??????Invigilator?Name:??
?
Signature:???????Signature:?
01. The steady-state concentration of a drug can be double by:
a. Doubling?the?both?rate?of?infusion?and?concentration?of? drug.?
b. Doubling?the?rate?of?infusion?only.?
c. Doubling?the?loading?dose?but?maintaining?the?infusion? rate.?
d. Tripling?the?rate?of?infusion.?
02. Phase II reactions of a drug biotransformation:
a. Decreases?its?water?solubility.?
b. Includes?activity?of?cytochrom?P?450.?
c. Usually?leads?to?inactivation?of?the?drug.?
d. Does?not?include?acetylation.?
03. Half-life of a drug may be helpful to determine:
a. Dosage?schedule?of?the?drug.?
b. Level?of?absorption.?
c. Distribution?into?different?body?systems.?
d. Time?to?get?the?steady?state.?
04. A 3 year old child has been admitted to emergency with suspicious of atropine
overdose as there are:
a. Abdominal?cramps.?
b. Increased?gastric?secretion.?
c. Increased?cardiac?rate.?
d. Papillary?constriction.?
?
05. Epinephrine does not cause increase concentrations of:
a. Glucose?in?blood.?
b. Lactate?in?blood.?
c. Free?fatty?acids?in?blood.?
d. Triglycerides?in?fat?cells.?
?
06. A 50 year old patient is having propranolol due to his cardiac problems but his
physician now wants to stop this drug; which of the following is the most
important reason for this step?
a. Familial?tremor.?
b. Partial?AV?heart?block.?
c. Mild?hypertension.?
d. Angina?pectoris.?
07. A young man of 24 years is suffering from Generalized Anxiety Disorder; which
drug may be preferred for his problem?
a. Zolpidem.?
b. Buspiron.?
c. Midazolam.?
d. Triazolam.?
08. Which of the following statements best describes the
mechanism of action of benzodiazepines?
a. Benzodiazepines?activate?GABA
B?
?receptors?in?the?spinal?cord.?
b. They?inhibit?GABA?transaminase?leading?to?increased?levels?of?GABA.?
c. They?block?glutamate?receptors??in?hierarchical?neuronal?pathways?in?the?brain.?
d. Benzodiazepines? increase? the? frequency? of? Cl
??
?channels?opening?which?are?
coupled?to?GABA
A?
receptors.?
09. Which of the following drugs when used for prolonged period in the
maintenance treatment of tonic-clonic seizures can lead to increased
metabolism of warfarin like drugs?
a. Phenobarbital.?
b. Meprobamate.?
c. Chlordiazepoxide.?
d. Triazolam.?
?
10. Characteristics of non-depolarizing neuromuscular blockade include which of
the following?
a. Block?of?post?tetanic?potentiation.?
b. Histamine?blocking?action.?
c. Poorly?sustained?tetanic?tension.?
d. Significant?muscle?fasciculations?during?onset?of?block.?
11. Which of the following drugs given preoperatively is used to prevent
postoperative pain caused by succinylcholine?
a. Dantrolene.?
b. Tubocurarine.?
c. Diazepam.?
d. Lidocaine.?
12. With prolonged use in seizure states, which of the following drugs can cause
coarsening of facial features, hirsutism, gingival hyperplasia and osteomalacia?
a. Valproic?acid.?
b. Carbamazepine.?
c. Ethosuximide.?
d. Phenytoin.?
?
13. Only Aspirin can:
a. Reduce?fever.?
b. Irreversible?inhibit?its?target?enzyme.?
c. Prevent?episodes?of?gouty?arthritis?with?long?term?use.?
d. Reduce?the?risk?of?colo?n? cancer.?
14. Indomethacin is preferred over Colchicine for Acute Attack of Gout because it is:
a. Less?likely?to?cause?gastrointestinal?bleeding.?
b. Less?likely?to?cause?diarrhea.?
c. Less?likely?to?cause?acute?renal?failure.?
d. More?likely?to?reduce?inflammation.?
15. Which of the following drugs is used in the treatment of rheumatoid arthritis?
a. Naproxen.?
b. Allopurinol.?
c. Colchicine.?
d. Sulfinpyrazone.?
16. The most dangerous adverse effect by using Fentanyl patches is:
a. Diarrhea.?
b. Relaxation?of?respiratory?muscles.?
c. Hypertension.?
d. Respiratory?depression.?
17. Morphine should be used with extreme caution in all of the following conditions
but not in:
a. Biliary?tract?surgery.?
b. Pulmonary?edema.?
c. Last?stage?of?labor.?
d. Hypothyroidism.?
18. A 35 year old patient complaining of severe pain along the right side of the jaw
and face; the best choice for this neuralgic pain is:
a. Methadone.?
b. Ibuprofen.?
c. Carbamazepine.?
d. Lorazepam.?
19. Which of the following local anesthetics is used exclusively for its good surface
activity and low toxic potential:
a. Cocaine.?
b. Benzocaine.?
c. Bupivacaine.?
d. Procaine.?
20. Which of the following drugs can cause methemoglobinemia when used in
larger doses for regional anesthesia?
a. Cocaine.?
b. Lidocaine.?
c. Bupivacaine.?
d. Prilocaine.?
21. Epinephrine added to a solution of lidocaine for local
anesthesia will:
a. Cause?cyanosis?locally.?
b. Increase?the?risk?of?convulsions.?
c. Increase?the?duration?of?local?anesthesia.?
d. Increase?the?absorption?of?lidocaine.?
22. Which of the following inhalational anesthetic agents is having fastest onset of
action?
a. Nitric?oxide.?
b. Isoflurane.?
c. Nitrous?oxide.?
d. Enflurane.?
23. To attempt reduction of a dislocated shoulder joint when Ketamine is used alone
it will ccause:
a. Respiratory?depression.?
b. Skeletal?muscle?rigidity.?
c. Hypotension.?
d. Analgesia.?
?
24. Which of the following drugs produces respiratory depression and so reversed
by flumazenil?
a. Fentanyl.?
b. Propofol.?
c. Ketamine.?
d. Midazolam.?
?
25. Cephalosporins show their antimicrobial action by:
a. Binding?to?cytoplasmic?receptor?proteins.?
b. Inhibition?of?beta?lactamases.?
c. Inhibition?of?transpeptidation?reactions.?
d. Interference?with?the?synthesis?of?ergosterol.?
26. The most appropriate drug regimen for empiric treatment of Gram-negative
bacilli in blood is:
a. Ampicillin?plus?sulbactam.?
b. Aztreonam.?
c. Cefazolin.?
d. Imipenem?plus?cilastatin.?
27. A BDS student while answering the question about ciprofloxacin gave various
statements; which of the following statements was rejected by the examiner?
a. Clinical?antagonism?occurs?when?used?with?Co?trimoxazole.?
b. Post?antibiotic?effects?are?similar?to?aminoglycosides.?
c. It?is?active?against?most?of?the?middle?ear?infecting? organisms.?
d. It?may?be?used?for?urinary?tract?infection.?
?
28. The mechanism underlying the resistance of G +ve organisms to macrolides is:
a. Decreased?drug?permeability?of?the?cytoplasmic?membrane.?
b. Methylation?of?binding?sites?on?the?50?S?ribosomal? subunit.?
c. Decreased?activity?of?uptake?mechanism.?
d. Formation?of?estrases?that?hydrolyze?the?lactone?ring.?
29. Doxycycline is:
a. Bactericidal.?
b. Not?excreted?in?the?feces.?
c. Having?a?short?elimination?half?life.?
d. Not?as?effective?as?tetracycline?against?H.pylori.?
30. Neomycin, an aminoglycoside is:
a. Least?nephrotoxic.?
b. Metabolized?by?hepatic?enzyme.?
c. Used?in?hepatic?coma.?
d. A?drug?of?choice?in?Rockey?Mountain?Spotted?fever.?
?
31. The toxic effect of amphotericin B which definitely require reduction of dose is:
a. Myelosuppression.?
b. Hepatitis.?
c. Renal?Toxicity.?
d. Hypotension.?
32. Which of the followings is useful topically for genital herpes infection?
a. Acyclovir.?
b. Amantadine.?
c. Ritonavir.?
d. Trifluridine.?
33. Acute hemorrhage cystitis is a common toxic effect seen with:
a. Vincristine.?
b. Tamoxifen.?
c. Doxorubicin.?
d. Cyclophosphamide.?
34. A young girl of 20 years has taken a suicidal overdose of Digoxin, the drug of
choice in her treatment will be:
a. Lidocaine.?
b. Phenytoin.?
c. Digoxin? antibodies.?
d. Potassium? chloride.?
35. A 45 year old patient developed severe thrombocytopenia due to unfractionated
heparin so the best alternative anticoagulant will be:
a. Lepirudin.?
b. Abciximab.?
c. Urokinase.?
d. Plasminogen.?
36. A 30 year old male suffering from cerebral edema will be best treated with:
a. Furosemide.?
b. Amiloride.?
c. Ethacrynic?acid.?
d. Mannitol.?
e. Acetazolamide.?
?
37. While prescribing a treatment to a young female patient suffering from peptic
ulcer associated with H. Pylori the gastroenterologist will neglect:
a. Tetracycline.?
b. Vancomycin.?
c. Amoxicillin.?
d. Metronidazole.?
?
38. A 35 year old lady who is on anticancer therapy is now suffering from severe
nausea and vomiting; which of the following drugs is having most effective
antiemetic actions in this case?
a. Dexamethasone.?
b. Levodopa.?
c. Apomorphine.?
d. Sucrulfate.?
39. Which of the following is a prophylactic antiasthmetic agent that stabilizes mast
cells:
a. Ipratropium.?
b. Prednisone.?
c. Terbutaline.?
d. Cromolyn.?
40. A senior dental surgeon is very much concerned about the systemic effect of the
topically -used drugs for plaque prevention; which of the following drugs will
least be considered by him due to the same reason?
a. Vancomycin.?
b. Bacitracin.?
c. Polymyxin???B.?
d. Clarithromycin.?
41. Peppermint is least useful in:
a. Gingivitis? .?
b. Periodontitis? .?
c. Young?children.?
d. Dental?gum.?
42. Clove oil:
a. Can?not?be?used?as?temporary?filling?material.?
b. Has?no?anti?inflammatory?effect.?
c. Can?not?increase?bleeding?when?applied.?
d. Has?antifungal?activity?also.?
?
43. Eugenol when sealed in a root canal preparation leads to severe tissue damage:
a. Without?pain?as?it?has?analgesic?effect.?
b. Without?pain?as?it?has?local?anesthetic? effect.?
c. Because?it?has?corrosive?effect.?
d. With?local?bleeding?also.?
44. Which of the following statements is least related to
Chlorhexidine (0.2%)?
a. It?is?useful?in?reducing?plaque?formation.?
b. It?can?cause?staining?of?the?teeth.?
c. There?is?increased?formation?of?calculi.?
d. It?is?not?effective?in?gingivit?is.?
45. Which of the following statements is rarely seen with
Azadirachta Indica (Neem):
a. Can?be?used?in?toothpaste.?
b. Shows?antimicrobial?activity.?
c. Has?mild?abrasive?effects.?
d. Can?not?inhibit?plaque?formation.?
?
46. Most potent fluoroquinolone against Mycobacterium leprae is??
a.?Levofloxacin?
b.?Ofloxacin?
c.?Moxifloxacin?
d.?Ciprofloxacin?
47. The antiretroviral drug combination to be avoided is??
a.?Zidovudine?+?Stavudine?
b.?Zidovudine?+?Lamivudine?
c.?Didanosine?+?Abacavir?
d.?Didanosine?+?Zidovudine?
?
48. Shortest acting non benzodiazepine hypnotic is??
a.?Zaleplon?
b.?Zolpidem?
c.?Zopiclone?
d.?Eszopiclone?
?
49. Which of the following is true regarding Drotaverine??
a.?M3?selective?muscarinic?antagonist?
b.?Causes?smooth?muscle?contraction?
c.?Causes?anticholinergic?side?effects?
d.?Inhibits?phosphodiesterase?4?
?
50. Which is associated with vaginal carcinoma in female offspring??
a.?Diethylstilbestrol?
b.?Phenytoin?
c.?ACE?inhibitors?
d.?Indomethacin?
51. Which of the following is not an action of muscarinic antagonists??
a.?Reduce?respiratory?secretions?
b.?Reduce?gastric?secretions?
c.?Contraction?of?radial?muscles?of?iris?
d.?Increase?rate?of?conduction?in?the?heart?
52. Which of the following is not a long acting muscarinic antagonist?
a.?Glycopyrronium?
b.?Aclidinium?
c.?Indacaterol?
d.?Umeclidinium?
?
53. Most potent fluoroquinolone against Mycobacterium leprae is?
a.?Levofloxacin?
b.?Ofloxacin?
c.?Moxifloxacin?
d.?Ciprofloxacin?
?
54. Which of the following is not related to a drug toxicity of Atenolol??
a. CHF??
b. Tachycardia??
c. AV?block??
d. Sedative?appearance?
?
55. Which of the following is the antidote for the toxin Benzodiazepines?
a. Flumazenil??
b. Methylene?blue??
c. Deferoxamine??
d. Alkalinize?urine?
?
56. Which of the following is considered a class IA Sodium Channel blocker?
a. Mexiletine??
b. Aminodarone??
c. Quinidine??
d. Procainamide?
?
57. Which of the following is not directly related to a drug toxicity of Ibuprofen?
a. Nausea??
b. Renal?dysfunction??
c. Anemia??
d. Muscle?wasting?
58. Which of the following is the primary site of activity for the drug Warfarin?
a. Kidney??
b. Liver??
c. Blood??
d. Heart?
59. Which of the following is not directly related to a drug toxicity of Nitroglycerin?
a. Headaches??
b. Tachycardia??
c. Dizziness??
d. Projectile?vomiting?
?
60. A drug ending in the suffix (navir) is considered a ______.
a. Antidepressant??
b. Protease?inhibitor??
c. Beta?antagonist??
d. H2?antagonist?
?
?
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This post was last modified on 21 September 2020