Hemwati Nandan Bahuguna Uttarakhand Medical Education University
Administrative Block, Govt. Doon Medical College Campus, Dehrakhas, Patel Nagar, Dehradun - 248001
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Phone: 0135 - 2723323 Fax: 0135 - 2723323
Ph.D. ENTRANCE EXAMINATION - 2020
Subject : Physiology Duration: 01:30 Hrs.
Date : 06.01.2020 Place: Dehradun Max Marks: 60
Student Name: Invigilator Name:
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Signature: Signature:
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The first heart sound is produced by the:
- Closure of the aortic and pulmonary valves
- Opening of the aortic and pulmonary valves
- Closure of the mitral and tricuspid valves
- Opening of the mitral and tricuspid valves
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Parasympathetic stimulation of heart causes:
- SA node decreases firing
- Increased AV node excitability
- Decreased ventricular contraction
- Tachycardia
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Normally, the rate of the heart beat in a human is determined by :
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- The bundle of His
- All cardiac muscle
- The sinoatrial node
- The cervical ganglion
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The ventricular repolarization in ECG is best seen in:
- "P" wave
- "Q" wave
- "R" wave
- "T" wave
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Cardiac output is not affected by :
- Heart rate
- Peripheral resistance
- Systolic blood pressure
- Venous return
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All the heart valves are open during which stage of cardiac cycle :
- Systolic ejection
- Isovolumetric relaxation
- Isovolumetric contraction
- None of the above
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Increased functional demand on the heart produces increased size of the myocardium by :
- Hyperplasia
- Hypertrophy
- Fatty infiltration
- Increased amounts of fibrous connective tissue
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Hunger centre of brain is:
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- Hypothalamus
- Stria nigra
- Frontal lobe
- Temporal lobe
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Pain sensation from the lateral extremities is transmitted by :
- Spino thalmamic tract
- Dorsal column
- Corticospinal tract
- Spinocerebellar tract
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Cell bodies of the neurons which carry taste sensation from the anterior 2/3" of the tongue are located in:
- Trigeminal nerve ganglion
- Geniculate ganglion
- Otic ganglion
- Superior cervical ganglion
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Respiratory centre is situated in:
- Medulla oblongata
- Spinal cord
- Midbrain
- Hypothalamus
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Sensations of pain from teeth and temperature are carried by
- Corticospinal tract
- Corticobulbar tract
- Lateral spinothalamic tract
- Ventral spinothalamic tract
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Group B fibers are present in:
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- Intrafusal fibers of the muscle spindle
- Golgi tendon apparatus
- Autoonomic preganglionic fibers
- Spinothalamic tracts
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Lesions within the basal ganglia produce the following signs except:
- Hypotonia
- Tremor
- Hemiballismus
- Athetosis
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In conn’s disease, there is an excess of:
- Adrenaline
- Aldosterone
- Cortisol
- Noradrenaline
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Which of the following hormones is released from the posterior pituitary?
- ACTH
- Antidiuretic hormone
- Growth hormone
- Luetinizing hormone
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Which of the following is associated with a low concentration of ionized calcium in the serum?
- Hypothyroidism
- Osteogenesis imperfecta
- Paget's disease of the bone
- Tetany
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Which hormone is released when serum calcium decreases
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- Parathormone
- Calcitonin
- Thyroxine
- Adrenaline
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Due fear which of the following hormones increases rapidly :
- Growth hormones
- Epinephrine
- Corticosteroid
- Thyroid hormone
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A child with stunted growth with a stuffed — belly, and short stature with mental retardation is suffering from the deficiency of which of the following:
- Thyroxine
- Growth hormone
- Rickets
- Parathyroid
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Trousseau’s sign and chovstek’s sings are positive in:
- Hyperparathyroidism
- Hypothyroidism
- Hypoparathyroidism
- Hyperthyroidism
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In jaundice, there is an unconjugated hyperbilirubinemia which is most likely due to
- Hepatitis
- Cirrhosis
- Obstruction of bile canaliculi
- Increased break down of red cells
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Histamine stiumlate the secretion of:
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- Gastrin by stomach
- Pancreatic enzymes
- HCL by stomach
- Amylase by salivary gland
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The most important function of hydrochloric acid in the stomach is:
- Destruction of bacteria
- Neutralization of chyme
- Activation of pepsinogen
- Stimulation of pancreatic secretion
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Pancreas produce:
- Pepsinogen
- Chymotrypsinogen
- Hydrochloric acid
- All of the above
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Intrinsic factor, which helps in absorption of Vit. By, is produced by :
- Parietal cells of stomach
- Chief cells of stomach
- Beta cells of pancreas
- Goblet cells
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Maximum secretory glands in stomach are:
- Fundic glands
- Pyloric glands
- Gastric glands
- Brunner's glands
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Which of the following coagulation factors is deficient in classical hemophilia?
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- VII
- IX
- X
- XII
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Which of the following is one for a patient on coumarin ( warfarin) therapy:
- Partial thromboplastin time ( PTT)
- Prothrombin time (PT)
- Bleeding time (BT)
- Capillary fragility test (CFT)
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The anticoagulant of choice used in the blood bank is:
- Calcium oxalate
- Heparin solution
- Acid citrate dextrose solution
- Sodium fluoride
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To preserve blood for transfusion later:
- Dilute with equal volume of 0.9% saline
- Add solution of sodium citrate
- Add solution of calcium chloride
- Add fibrinogen
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T- lymphocytes function to :
- Antibody production
- Complement activation
- Lymphokine production and delayed hypersensitivity
- Immediate hypersensitivity
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Haemoglobin is the major buffer in blood, bicarbonate ions diffuses out of erythrocyte into plasma in exchange of:
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- Potassium
- Phosphate
- Carbonic acid
- Chloride ion
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The eosinophil count in the peripheral blood smear is increased in:
- Allergic conditions
- Anaemia
- Polycythemia
- Typhoid fever
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During exercise:
- Cerebral blood flow increases if there is increase in systolic blood pressure
- Body temperature increases
- Blood flow to muscle increases after 172 minute
- Lymphatic flow from muscle decrease
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The percentage of body water is greater in
- Male than in females
- Children than in adult
- Obese than in lean individuals
- old than in young objects
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Meiotic division of male germ cells commence
- During intra - uterine life
- just before birth
- by around 6 years after birth
- by around 16 years
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Primary cause of bleeding disorder in liver damage is due to
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- Decreased level of prothrombin
- Lack of vitamin K
- Platelet deficiency
- Lack of vitamin B
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T- lymphocytes play a primary role in
- Production of Antibodies
- production of lymphokines and delayed hypersensitivity
- Activation of complement system
- Immediate Hypersensitivity
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Gut associated lymphoid tissue ( GALT) is primarily located in-
- Lamina propria
- Submucosa
- Muscularis
- Serosa
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Which of the following events DO NOT occur in rods in response to light-
- Structural changes in rhodopsin
- Activation of transducin
- Decreased intracellular cGMP
- Opening of Na+ channels
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Calcium ions triggers muscle contraction by binding to :
- Actin
- Myosin
- Troponin
- Tropomyosin
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The contractile element in a skeletal muscle is present in:
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- Sarcolemma
- Sarcoplasm
- Myofibril
- Endomysium
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Contractile element in myofibril is:
- Hband
- Sarcoplasm
- Sarcomere
- Aline
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Skeletal muscles:
- Contracts when calcium is taken up by sacroplasmic reticulum
- Contracts when actin and myosin filaments shorten
- Contraction is initiated by calcium binding to troponin
- Contraction is initiated by calcium binding to tropomyosin
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The following electrodes are used to detect the muscle activity without pain:
- Surface electrode
- Round electrode
- Hook electrode
- Needle electrode
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Rigor mortis results after death is due to
- Failure of acetylcholine to diffuse
- Failure of ATP supply
- Failure of break down of calcium bridges
- None of the above
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A decrease in the urine output is called :
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- Dysuria
- Nocturia
- Oliguria
- Plyuria
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In osmotic diurestis there is:
- Increase in renal blood flow
- Increase in glomerular filtration rate
- Increase in NaCl concentration in urine
- Decrease in reabsorption of Na Cl
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Test for estimating kidney function is:
- Serum creatinine
- Serum phosphatase
- Inulin test
- Insulin test
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Carbonic anhydrase in the kidney tubular cells is known to be associated with:
- Urea
- Chloride
- Bicarbonate ion
- Carbohydrate
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Renin is released from the kidney in all except:
- Sympathetic stimulation
- Decrease in the concentration of sodium ions in the proximal tubules
- Decrease in the concentration of sodium ions in the distal tubules
- Fall in the BP
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The kidney secrete all of the following hormones except:
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- Renin
- Erythropoietin
- Vasopressin
- 1,2,5 Dihydroxy cholecalciferol
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The glomerular filtration rate of the human kidney may be determined by measuring the plasma clearance of:
- PAH
- Urea
- Inulin
- Glucose
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Brush border is seen in:
- Bowman's capsule
- Proximal convoluted tubule
- Distal convoluted tubule
- Loop of Henle
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During inspiration when the diaphragm contracts, the intrapleural pressure becomes:
- More negative
- Less negative
- Positive
- Equal to the intra alveolar pressure
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A decrease in the arterial PO, is seen in:
- Decrease in hemoglobin concentration of arterial blood
- Paralysis of inspiratory muscles
- Sluggish blood flow
- High altitudes
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The major sign of hypoventilationis:
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- Cyanosis
- Dysponoea
- Hypercapnia
- Hypoxia
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Most effective method of assessing breathing is by measuring:
- Tidal volume
- Respiratory rate
- Alveolar ventilation
- FEV1
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The volume of gas in the lungs at the end of normal expiration is
- Expiratory reserve volume
- Functional residual capacity
- Residual volume
- Inspiratory reserve volume
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