Download JNTUH Pharm D 3rd Year PH301 Pharmacology Ii Question Paper

Download JNTUH (Jawaharlal Nehru Technological University Hyderabad) Pharm-D (Doctor of Pharmacy) 3rd Year PH301 Pharmacology Ii Previous Question Paper

Code No: PH301
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
Pharm.D III Year Supplementary Examinations, October - 2019
PHARMACOLOGY ? II
Time: 3hours Max.Marks:70
Answer any five questions
All questions carry equal marks
- - -

1.a) Briefly discuss about Direct and Indirect Thrombin Inhibitors.
b) Why NSAIDS comes under the category of antiplatelets? Describe briefly the usage of
aspirin in various clinical conditions? [7+7]

2.a) Among loop and thiazide diuretics which diuretics are best suitable for Postmenopausal
Women and Why?
b) Write the pharmacological mechanism of action, clinical use and side effects of following
drugs.
i) Ticlopidine
ii) Ridogrel
iii) Eptifibatide
iv) Ximelagatran. [6+8]

3.a) Describe the antibiotics which affect the bacterial cell membrane with pharmacological
mechanism of action.
b) How NRTI and NNRTI differs in terms of reverse transcriptase enzyme inhibition?
c) Which nucleoside derivative is approved by FDA for the inhibition of HIV from mother
to child? Why? [6+6+2]

4.a) Why Aspirin is not given through the I.V route although it has an extensive first pass
metabolism?
b) How cyclooxygenase pathway is linked to PI3 kinase Pathway?
c) Through which pathways growth hormone promotes the cell division and differentiation?
Explain using a suitable diagram. [4+4+6]

5.a) How prokaryotes are different from eukaryotes in synthesizing a protein?
b) What is the central dogma of life and describe in short about the transcription and
translation? [7+7]

6.a) How potassium sparing diuretics spares the potassium in the body? Write about
aldosterone antagonists and direct sodium channel blockers involved in diuresis?
b) Write the pharmacological mechanism of action and side effect profile of the following
drugs.
i) Cyclosporin A
ii) Azathioprine
iii) Streptokinase
iv) Tacrolimus. [7+7]

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Code No: PH301
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
Pharm.D III Year Supplementary Examinations, October - 2019
PHARMACOLOGY ? II
Time: 3hours Max.Marks:70
Answer any five questions
All questions carry equal marks
- - -

1.a) Briefly discuss about Direct and Indirect Thrombin Inhibitors.
b) Why NSAIDS comes under the category of antiplatelets? Describe briefly the usage of
aspirin in various clinical conditions? [7+7]

2.a) Among loop and thiazide diuretics which diuretics are best suitable for Postmenopausal
Women and Why?
b) Write the pharmacological mechanism of action, clinical use and side effects of following
drugs.
i) Ticlopidine
ii) Ridogrel
iii) Eptifibatide
iv) Ximelagatran. [6+8]

3.a) Describe the antibiotics which affect the bacterial cell membrane with pharmacological
mechanism of action.
b) How NRTI and NNRTI differs in terms of reverse transcriptase enzyme inhibition?
c) Which nucleoside derivative is approved by FDA for the inhibition of HIV from mother
to child? Why? [6+6+2]

4.a) Why Aspirin is not given through the I.V route although it has an extensive first pass
metabolism?
b) How cyclooxygenase pathway is linked to PI3 kinase Pathway?
c) Through which pathways growth hormone promotes the cell division and differentiation?
Explain using a suitable diagram. [4+4+6]

5.a) How prokaryotes are different from eukaryotes in synthesizing a protein?
b) What is the central dogma of life and describe in short about the transcription and
translation? [7+7]

6.a) How potassium sparing diuretics spares the potassium in the body? Write about
aldosterone antagonists and direct sodium channel blockers involved in diuresis?
b) Write the pharmacological mechanism of action and side effect profile of the following
drugs.
i) Cyclosporin A
ii) Azathioprine
iii) Streptokinase
iv) Tacrolimus. [7+7]

02
7.a) Explain clinical use and side effects:
i) Clo-trimaxazole
ii) Amoxicillin-Potassium Clavulanate
iii) HAART
iv) Clotrimazole
b) What is the relevance of therapeutic drug monitoring? Give few suitable examples? [7+7]


8. Describe the endpoints to define Acute, sub acute and chronic toxicities? And briefly
discuss about OECD test guidelines for the chemicals? [14]


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