--- Content provided by FirstRanker.com ---Answer any five questions
All questions carry equal marks
- - -
1.a) Briefly discuss about Direct and Indirect Thrombin Inhibitors.
aspirin in various clinical conditions? [7+7]
2.a) Among loop and thiazide diuretics which diuretics are best suitable for Postmenopausal
Women and Why?
drugs.
i) Ticlopidine
ii) Ridogrel
iii) Eptifibatide
3.a) Describe the antibiotics which affect the bacterial cell membrane with pharmacological
mechanism of action.
b) How NRTI and NNRTI differs in terms of reverse transcriptase enzyme inhibition?
to child? Why? [6+6+2]
4.a) Why Aspirin is not given through the I.V route although it has an extensive first pass
metabolism?
c) Through which pathways growth hormone promotes the cell division and differentiation?
Explain using a suitable diagram. [4+4+6]
5.a) How prokaryotes are different from eukaryotes in synthesizing a protein?
translation? [7+7]
6.a) How potassium sparing diuretics spares the potassium in the body? Write about
aldosterone antagonists and direct sodium channel blockers involved in diuresis?
drugs.
i) Cyclosporin A
ii) Azathioprine
iii) Streptokinase
02
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Code No: PH301
Pharm.D III Year Supplementary Examinations, October - 2019
PHARMACOLOGY ? II
Time: 3hours Max.Marks:70
Answer any five questions
- - -
1.a) Briefly discuss about Direct and Indirect Thrombin Inhibitors.
b) Why NSAIDS comes under the category of antiplatelets? Describe briefly the usage of
2.a) Among loop and thiazide diuretics which diuretics are best suitable for Postmenopausal
Women and Why?
b) Write the pharmacological mechanism of action, clinical use and side effects of following
i) Ticlopidine
ii) Ridogrel
iii) Eptifibatide
iv) Ximelagatran. [6+8]
3.a) Describe the antibiotics which affect the bacterial cell membrane with pharmacological
mechanism of action.
b) How NRTI and NNRTI differs in terms of reverse transcriptase enzyme inhibition?
c) Which nucleoside derivative is approved by FDA for the inhibition of HIV from mother
4.a) Why Aspirin is not given through the I.V route although it has an extensive first pass
metabolism?
b) How cyclooxygenase pathway is linked to PI3 kinase Pathway?
Explain using a suitable diagram. [4+4+6]
5.a) How prokaryotes are different from eukaryotes in synthesizing a protein?
b) What is the central dogma of life and describe in short about the transcription and
6.a) How potassium sparing diuretics spares the potassium in the body? Write about
aldosterone antagonists and direct sodium channel blockers involved in diuresis?
b) Write the pharmacological mechanism of action and side effect profile of the following
i) Cyclosporin A
ii) Azathioprine
iii) Streptokinase
iv) Tacrolimus. [7+7]
02
7.a) Explain clinical use and side effects:
i) Clo-trimaxazole
ii) Amoxicillin-Potassium Clavulanate
iv) Clotrimazole
b) What is the relevance of therapeutic drug monitoring? Give few suitable examples? [7+7]
discuss about OECD test guidelines for the chemicals? [14]
---ooOoo---
FirstRanker.com - FirstRanker's Choice
All questions carry equal marks
- - -
1.a) Briefly discuss about Direct and Indirect Thrombin Inhibitors.
--- Content provided by FirstRanker.com ---
b) Why NSAIDS comes under the category of antiplatelets? Describe briefly the usage ofaspirin in various clinical conditions? [7+7]
2.a) Among loop and thiazide diuretics which diuretics are best suitable for Postmenopausal
Women and Why?
--- Content provided by FirstRanker.com ---
b) Write the pharmacological mechanism of action, clinical use and side effects of followingdrugs.
i) Ticlopidine
ii) Ridogrel
iii) Eptifibatide
--- Content provided by FirstRanker.com ---
iv) Ximelagatran. [6+8]3.a) Describe the antibiotics which affect the bacterial cell membrane with pharmacological
mechanism of action.
b) How NRTI and NNRTI differs in terms of reverse transcriptase enzyme inhibition?
--- Content provided by FirstRanker.com ---
c) Which nucleoside derivative is approved by FDA for the inhibition of HIV from motherto child? Why? [6+6+2]
4.a) Why Aspirin is not given through the I.V route although it has an extensive first pass
metabolism?
--- Content provided by FirstRanker.com ---
b) How cyclooxygenase pathway is linked to PI3 kinase Pathway?c) Through which pathways growth hormone promotes the cell division and differentiation?
Explain using a suitable diagram. [4+4+6]
5.a) How prokaryotes are different from eukaryotes in synthesizing a protein?
--- Content provided by FirstRanker.com ---
b) What is the central dogma of life and describe in short about the transcription andtranslation? [7+7]
6.a) How potassium sparing diuretics spares the potassium in the body? Write about
aldosterone antagonists and direct sodium channel blockers involved in diuresis?
--- Content provided by FirstRanker.com ---
b) Write the pharmacological mechanism of action and side effect profile of the followingdrugs.
i) Cyclosporin A
ii) Azathioprine
iii) Streptokinase
--- Content provided by FirstRanker.com ---
iv) Tacrolimus. [7+7]02
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Code No: PH301
--- Content provided by FirstRanker.com ---
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABADPharm.D III Year Supplementary Examinations, October - 2019
PHARMACOLOGY ? II
Time: 3hours Max.Marks:70
Answer any five questions
--- Content provided by FirstRanker.com ---
All questions carry equal marks- - -
1.a) Briefly discuss about Direct and Indirect Thrombin Inhibitors.
b) Why NSAIDS comes under the category of antiplatelets? Describe briefly the usage of
--- Content provided by FirstRanker.com ---
aspirin in various clinical conditions? [7+7]2.a) Among loop and thiazide diuretics which diuretics are best suitable for Postmenopausal
Women and Why?
b) Write the pharmacological mechanism of action, clinical use and side effects of following
--- Content provided by FirstRanker.com ---
drugs.i) Ticlopidine
ii) Ridogrel
iii) Eptifibatide
iv) Ximelagatran. [6+8]
--- Content provided by FirstRanker.com ---
3.a) Describe the antibiotics which affect the bacterial cell membrane with pharmacological
mechanism of action.
b) How NRTI and NNRTI differs in terms of reverse transcriptase enzyme inhibition?
c) Which nucleoside derivative is approved by FDA for the inhibition of HIV from mother
--- Content provided by FirstRanker.com ---
to child? Why? [6+6+2]4.a) Why Aspirin is not given through the I.V route although it has an extensive first pass
metabolism?
b) How cyclooxygenase pathway is linked to PI3 kinase Pathway?
--- Content provided by FirstRanker.com ---
c) Through which pathways growth hormone promotes the cell division and differentiation?Explain using a suitable diagram. [4+4+6]
5.a) How prokaryotes are different from eukaryotes in synthesizing a protein?
b) What is the central dogma of life and describe in short about the transcription and
--- Content provided by FirstRanker.com ---
translation? [7+7]6.a) How potassium sparing diuretics spares the potassium in the body? Write about
aldosterone antagonists and direct sodium channel blockers involved in diuresis?
b) Write the pharmacological mechanism of action and side effect profile of the following
--- Content provided by FirstRanker.com ---
drugs.i) Cyclosporin A
ii) Azathioprine
iii) Streptokinase
iv) Tacrolimus. [7+7]
--- Content provided by FirstRanker.com ---
02
7.a) Explain clinical use and side effects:
i) Clo-trimaxazole
ii) Amoxicillin-Potassium Clavulanate
--- Content provided by FirstRanker.com ---
iii) HAARTiv) Clotrimazole
b) What is the relevance of therapeutic drug monitoring? Give few suitable examples? [7+7]
--- Content provided by FirstRanker.com ---
8. Describe the endpoints to define Acute, sub acute and chronic toxicities? And brieflydiscuss about OECD test guidelines for the chemicals? [14]
---ooOoo---
--- Content provided by FirstRanker.com ---
02FirstRanker.com - FirstRanker's Choice