Download PTU B.Pharmacy 2020 March 4th Sem 75845 Physical Pharmaceutics II Question Paper

Roll No. _________________________

Total No. of Pages : 02

Total No. of Questions: 13

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B.Pharma (2017 Batch) (Sem.-4)

PHYSICAL PHARMACEUTICS-II

Subject Code: BP-403T

M.Code: 75845

Time: 3 Hrs.

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Max. Marks : 75

INSTRUCTIONS TO CANDIDATES :

1. SECTION-A is COMPULSORY consisting of TEN questions carrying TWO marks each.
2. SECTION-B contains THREE questions carrying TEN marks each and student has to attempt any TWO questions.
3. SECTION-C contains NINE questions carrying FIVE marks each and student has to attempt any SEVEN questions.

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SECTION-A

1. Answer briefly :

   1. Colloids
   2. Thixotropy and negative thixotropy
   3. coacervation

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   4. Difference between stress and strain
   5. Heckel plot is valid for which types of solids material?
   6. HLB scale
   7. Degree of flocculation and its units
   8. Porosity

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   9. Ionic strength vs. degradation of pharmaceutical products
   10. Arrhenius equation

SECTION-B

2. Discuss Principle, construction, working and applications of cone and plate viscometer.

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3. Discuss Accelerated stability analysis.
4. Discuss different derived properties of powders along with their significance in pharmacy. How they are determined or calculated?

SECTION-C

5. What is a Plug flow? Is it desirable while recording a rheogram?
6. Discuss the stability of pharmaceutical products against oxidation.

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7. Explain sedimentation volume and role of flocculating agents in suspensions.
8. Discuss DLVO theory.
9. Enumerate physical factors that influencing degradation of pharmaceuticals. Discuss any one in detail.
10. Write a note on peptization and protection of colloids.
11. Enumerate different methods to determine particle size and discuss any one in detail.

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12. A prescription for a liquid aspirin is called for. It contains 325mg/5ml or 6.5g/100ml. Solubility of aspirin at 25°C is 0.33g/100ml. Therefore the suspension will definitely be a suspension. Other ingredients in the prescription cause the product to have a pH of 6. The first order rate constant for aspirin degradation in the solution is 4.5×10^-6 sec^-1. Calculate the zero order rate constant. Determine the self life, t₉₀ for the liquid preparation, assuming that the product is satisfactory until at the time at which it has decomposed to 90% of its original concentration (i.e 10% decomposition) at 25°C.
13. Calculate the HLB value of a blend of equal amounts of Polysorbate 80 and sorbitan monooleate, the HLB values of 2 surfactants being 15 and 4.3 respectively.

NOTE: Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.

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