Download PTU B.Pharmacy 2020 March 7th Sem 46163 Pharmaceutical Chemistry VI Question Paper

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Roll No. ____________________ Total No. of Pages : 02

Total No. of Questions : 10

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B.Pharmacy (Sem.-7)

PHARMACEUTICAL CHEMISTRY-VII/PHARMACEUTICAL CHEMISTRY-VII (MEDICINAL CHEMISTRY)/MEDICINAL CHEMISTRY-II

Subject Code : PHM-475

M.Code : 46163

Time : 3 Hrs. Max. Marks : 80

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INSTRUCTIONS TO CANDIDATES :

1. SECTION-A is COMPULSORY consisting of FIFTEEN questions carrying TWO marks each.
2. SECTION-B contains FIVE questions carrying FIVE marks each and students have to attempt any FOUR questions.
3. SECTION-C contains FOUR questions carrying TEN marks each and students have to attempt any THREE questions.

SECTION-A

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1. Write short notes on :
   1. What are contraceptives?
   2. Give two examples of inhalation anesthetics.
   3. What are side effects of barbiturates?
   4. Define opiates.
   5. What is methadone?

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   6. Define antitussives.
   7. What are CNS stimulants?
   8. Draw structure and give IUPAC name of phenytoin.
   9. Define anxiolytics.
   10. Draw structure and give MOA of acetazolamide.

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   11. What are statins?
   12. Give IUPAC name and clinical uses of methyldopa.
   13. Draw structure and give IUPAC name of captopril.
   14. Draw structure and give uses of furosemide.
   15. Give MOA of verapamil.

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SECTION-B

2. Discuss SAR of benzoic acid derivatives for local anaesthetic activity.
3. Classify anticonvulsants with structural example of each class. Comment on typical structural features required for anticonvulsant activity.
4. Write a note on tricyclic antidepressants.

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5. Explain diuretic action of carbonic anhydrase inhibitors. Give synthesis of acetazolamide.
6. Give synthesis of nalorphine. Comment on endogenous opioid peptides.

SECTION-C

7. Describe four stages of cholesterol biosynthesis. Give SAR of progestational agents.
8. Describe structures of ß-blockers clinically approved for the treatment of hypertension. Give synthesis of propranolol.

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9. What are ACE inhibitors? Name any two prodrugs which act as ACE inhibitor along with structure. Discuss their clinical applications.
10. Write short note on any two :
    1. SAR of glucocorticoids.
    2. Cardiac glycosides.
    3. SAR of phenothiazine antipsychotics.

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NOTE: Disclosure of identity by writing mobile number or making passing request on any page of Answer sheet will lead to UMC case against the Student.

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