Download PTU B.Pharmacy 2020 March 7th Sem 71756 Pharmaceutical Chemistry?VII Question Paper

Roll No. ____________________________________ Total No. of Pages : 02

Total No. of Questions : 10

B.Pharma (2012 to 2016) (Sem.-7)

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PHARMACEUTICAL CHEMISTRY-VII

(Medicinal Chemistry-II)

Subject Code : BPHM-704

M.Code : 71756

Time : 3 Hrs. Max. Marks : 80

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INSTRUCTIONS TO CANDIDATES :

1. SECTION-A is COMPULSORY consisting of FIFTEEN questions carrying TWO marks each.
2. SECTION-B contains FIVE questions carrying FIVE marks each and students have to attempt any FOUR questions.
3. SECTION-C contains FOUR questions carrying TEN marks each and students have to attempt any THREE questions.

SECTION-A

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1. Answer briefly :

   1. Classify general anesthetics.
   2. Comment upon narcotic antagonist.
   3. Give synthesis of phenytoin.
   4. Give mechanism of action of Haloperidol.

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   5. Why thiazide diuretics are referred as low efficacy agents.
   6. Mention the mechanism of action of hypolipidemic agents.
   7. What are site 1 diuretics?
   8. Give chemical name of nifedipine.
   9. Give the structure of estrogen.

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   10. Comment upon role of theophylline.
   11. Classify opioid analgesics.
   12. Draw the structure of any one anticoagulant.
   13. Give the moa of isosorbide dinitrate.
   14. Write the structure and moa of chlorpromazine.

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   15. Name any one opium alkaloid and give its use.

SECTION-B

2. Enumerate various steps involved in biosynthesis of cholesterol.
3. Comment upon stereochemistry of steroidal nucleus.

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4. Discuss in detail moa and SAR of Phenothiazines.
5. Give moa, synthesis and uses of Lignocaine.
6. Classify sedatives. Comment upon hydantoins used as sedatives.

SECTION-C

7. 1. Outline the synthetic procedure of any one antianxiety agent.

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   2. Comment upon the chemistry of MAO inhibitors.
8. 1. Give detailed account of chemistry of cardiac glycosides.
   2. What are antiarrythmic agents. Classify.

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9. Give the structure and therapeutic uses of the following drugs:
   1. Carbamezepine
   2. Nitrazepam
   3. Procaine
   4. Lignocaine
   5. Nikethemide

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10. Explain the chemistry and SAR involved for various classes of opioid analgesics. Write down the synthesis for pentozacin.

NOTE: Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.

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