Date: 20-11-2023
RUHS
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPER I
Time: 3 hours Max Marks: 100

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Instructions: INSTRUCTIONS: Attempt all
questions in both sections: (Use separate
answer book for each section)
Section 1
1. Fill in the blanks: (6)

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a. Monosaccharide which causes sequestering of
phosphate in the cell ______
b. Phenylpyruvic acid in urine is detected by
______
c. Ferrochelatase is deficient in ______

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condition.
d. Lysine is a limiting amino acid in ______ food.
e. Vitamin E acts synergistically with ______ jon.
2. Choose the correct option in the following
multiple choice questions: 5 x 1 = 05 (4)

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a. Phospholipid deficient in newborn suffering
from respiratory distress syndrome.
a) Phosphatidylethanolamine
b) Phosphatidylcholine
c) Phosphatidylserine

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d) Cardiolipin
b. Folate reductase in inhibited by drug.
a) Erythromycin
b) Chloramphenicol
c) Methotrexate

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d) 5-Fluorouracil
c. Effect of thromboxane is.
a) Increase in platelet aggregation
b) Relaxation of smooth muscle
c) Decrease in blood pressure

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d) Produces vasodilation
d. Following congenital disease is associated
with conjugated hyperbilirubinemia.
a) Crigler - Najjar syndrome
b) Gilbert's disease

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c) Dubin-Johnson's syndrome
d) Congenital spherocytosis
e. All of the following amino acids contribute to
purine synthesis EXCEPT.
a) Glycine

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b) Cysteine
c) Glutamine
d) Aspartate

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3. Clinical Case study: A six months old infant
began to vomit occasionally and ceased to gain

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weight. At 9 months of age, he was admitted to
the hospital, he was drowsy, with fever,
hepatomegaly and failure to feed. Urine
analysis mealed high amount of glutamine and
uracil. Blood investigations shouted absence of

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urea. EEG was grossly abnormal.
a. What is the most probable diagnosis?
b. Why are glutamine & uracil elevated?
c. What is the cause of brain involvement in this
patient?

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d. What can be the treatment modality? (15)
4. Differentiate between (Any five): (10)
a. Proteoglycans & Glycoproteins
b. G-6-PD & G-6-Phosphatase
c. Pre hepatic and post hepatic Jaundice

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d. Haemoglobin & Myoglobin
e. Carnitine & Creatine
f. Uncompetitive & Non-competitive inhibition
5. Explain briefly (Any three): (15)
a. Dehydration

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b. Lipotropic factors
c. Isoenzymes

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d. Orotic aciduria

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Section 2
6. Describe the role of respiratory and renal

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regulation of pH. Add note on pH derangement
due to diabetes. (20)
7. Explain Why (Any five): (10)
a. Vitamin B12 deficiency leads to folate trap.
b. Patients of pancreatic insufficiency are advised

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to take medium and small chain fatty acids.
c. Glucose uptake in intestine & kidney is called
secondary active transport.
d. Uronic acid pathway is important for
detoxification of drugs.

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e. Carnitine deficiency leads to hypoglycaemia.
f. Arginine becomes semi-essential.
8. Explain briefly (Any four): (20)
a. Biologically active nucleotides & peptides
b. Uncouplers

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c. Methionine metabolism
d. Niemann - Pick disease
e. Mercury poisoning
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