RUHS
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPER II
Date: 04-07-2021
Max Marks: 100

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Time: 3 hours
Instructions: INSTRUCTIONS: Attempt all
questions in both sections: (Use separate answer
book for each section)
Section 1

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1. Fill in the blanks: (6)
a. The respiratory quotient for protein is
_________
b. The exogenous substance used to measure
glomerular filtration rate (GFR) is _________

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c. The enzyme protects DNA from aging is
_________
d. Sickle-cell anemia is a classical examples of
_________ mutation.
e. The primary transcript produced by RNA

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polymerase II in eukaryotes is _________
f. The immunoglobin that can find mast cells and

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release of histamine and slow reacting
substance is,_________
2. Choose the correct option in the following

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multiple choice questions: (4)
a. Northern blotting techniques is for detection of:
a) Protein
b) DNA
c) RNA

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d) All
b. Alpha-fetoprotein level is serum is increased in:
a) Prostate cancer
b) Hematoma
c) Ovarian cancer

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d) Choriocarcinoma
c. Which mineral is essential for normal
maturation of collagen?
a) Taq polymerase
b) Restriction Endonuclease

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c) Reverse transcriptase
d) Telomerase
d. Superoxide radicals can be detoxified by,
a) Cytochrome c
b) Cytochrome b

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c) Cytochrome a
d) None

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3. A 40 year old man was brought to the hospital
with mid Epigastric pain/fever and vomiting after
cating 'greasy meals'. His stools were clay in

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colour and contained (15) fat. The man's urine
was found to be dark in colour. Laboratory finding
shows serum bilirubin was 14 mg/dl and the urine
gave a positive test for bile salt.
a. What is the likely diagnosis of the patient?

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b. Explain the rationale behind diagnosis.
c. Which type of bilirubin is high in this disease?
d. What are the causes for this disease?
e. What is the clinical management for this
disease?

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4. Write short notes on (10)
a. Significance of reverse cholesterol transport
b. Effect of hyperglycemia on sorbitol pathway
c. Regulation of heme synthesis
d. Metabolic acidosis

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e. Metabolic adaptation in the starvation
f. Salvage pathway of purine synthesis (A.393)
5. Explain briefly (15)
a. Ketogenesis and its regulation (A.295)
b. Biogenic amines

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c. Vitamins as coenzymes

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d. Electron transport chain
Section 2
6. Describe hormonal regulation of blood glucose
levels. What are the metabolic derangements in

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diabetes mellitus? Add a note on Glycated
hemoglobin (HbA1c) and (20) its clinical
significance.
7. Explain why (any five) (10)
a. Methotrexate acts as a competitive inhibitor.

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b. Glutathione acts as a biology active peptide.
c. Ammonia is toxic (A.336)
d. Fluoride acts as a in inhibitor of glucolysis.
e. G6PD deficiency causes a drug induced
hemolytic anemia

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f. Patients with Alkaptonuria develop Ochronosis
8. Explain briefly (20)
a. Erythropoietic Porphyrias
b. Isoenzymes in clinical diagnosis (A.114)
c. Phenylketonuria (A.352)

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d. Disorders of iron metabolism
e. Fatty liver and lipotropic factors (A. 324)
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Document Outline

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