RUHS
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPERI
Time: 3 hours
Max Marks: 100
Instructions: INSTRUCTIONS: Attempt all questions
in both sections: (Use separate answer book for each
section)
Section 1
a. Von Girke's disease is due to the deficiency of the
enzyme ____________
b. Functionally active form of Vitamin D is
____________
d. Acrodermatitis enteropathica is due to defective
absorption of ____________
e. The major catabolic product of the amino acid
____________
____________
2. Choose the correct option in the following choice
question: (4)
a. lodine is required for the synthesis of:
a) Insulin
b) Thyroxine
c) Calcitonin
d) Vitamin B12
b. Which of the following enzyme is dependent on
a) Transaldolase
b) Transketolase
c) Glucose-6-phosphatase
d) Hexokinase
a) Liver
b) Osteocytes
c) RBC
d) Erythroid cells of bone marrow
starvation is:
a) Ketone body
b) Glucose
c) Fatty acid
3. A 4 month old infant was brought to the hospital
for consultation. She had lack of pigmentation from
skin, hair and iris of the eye. Photophobia was also
present. a. (15)
b. Name the deficient pigment and the amino acid
from which it is synthesized
c. What is the pattern of inheritance?
d. Name the enzyme responsible for the defect and
e. Explain treatment/management of the disease.
4. Write short notes on (any five) (10)
a. Importance of dietary fibres.
b. Detoxification by conjugation
d. Differential diagnosis of jaundice
e. Technique of polymerase chain reaction (PCR)
5. Explain briefly (15)
a. Inhibitors of translations
c. DNA repair mechanism
d. Disorder of thyroid function
Section 2
6. Explain process of transcription in prokaryotes.
inhibitors of transcription. (20)
7. Explain why (10)
a. Vitamin E act as an antioxidant
b. Telomerase have been implicated in aging process
c. Oedema is major manifestation in kwashiorkor.
d. Methotrexate is used an anti cancer agent
e. Genetic code is specific (A. 547)
f. Serum creatinine is more sensitive para meter than
8. Explain briefly: (20)
a. Operon concept of gene regulation
b. Salient features of genetic code
c. Application of recombinant DNA technology
***
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPERI
Time: 3 hours
Max Marks: 100
--- Content provided by FirstRanker.com ---
Date: 02-07-2021Instructions: INSTRUCTIONS: Attempt all questions
in both sections: (Use separate answer book for each
section)
Section 1
--- Content provided by FirstRanker.com ---
1. Fill in the blanks (6)a. Von Girke's disease is due to the deficiency of the
enzyme ____________
b. Functionally active form of Vitamin D is
____________
--- Content provided by FirstRanker.com ---
c. The constituent unit of insulin is ____________d. Acrodermatitis enteropathica is due to defective
absorption of ____________
e. The major catabolic product of the amino acid
____________
--- Content provided by FirstRanker.com ---
f. The first codon to be translated on mRNA is____________
2. Choose the correct option in the following choice
question: (4)
a. lodine is required for the synthesis of:
--- Content provided by FirstRanker.com ---
a) Insulin
b) Thyroxine
c) Calcitonin
d) Vitamin B12
b. Which of the following enzyme is dependent on
--- Content provided by FirstRanker.com ---
thiamine pyrophosphate (TPP) for its activitya) Transaldolase
b) Transketolase
c) Glucose-6-phosphatase
d) Hexokinase
--- Content provided by FirstRanker.com ---
c. Synthesis of heme does not occur in:a) Liver
b) Osteocytes
c) RBC
d) Erythroid cells of bone marrow
--- Content provided by FirstRanker.com ---
d. Main energy source of brain during prolongedstarvation is:
a) Ketone body
b) Glucose
c) Fatty acid
--- Content provided by FirstRanker.com ---
d) Fructose3. A 4 month old infant was brought to the hospital
for consultation. She had lack of pigmentation from
skin, hair and iris of the eye. Photophobia was also
present. a. (15)
--- Content provided by FirstRanker.com ---
a. What is the likely diagnosis?b. Name the deficient pigment and the amino acid
from which it is synthesized
c. What is the pattern of inheritance?
d. Name the enzyme responsible for the defect and
--- Content provided by FirstRanker.com ---
write the reaction catalyzed by the enzymee. Explain treatment/management of the disease.
4. Write short notes on (any five) (10)
a. Importance of dietary fibres.
b. Detoxification by conjugation
--- Content provided by FirstRanker.com ---
c. Prionsd. Differential diagnosis of jaundice
e. Technique of polymerase chain reaction (PCR)
5. Explain briefly (15)
a. Inhibitors of translations
--- Content provided by FirstRanker.com ---
b. Point mutationc. DNA repair mechanism
d. Disorder of thyroid function
Section 2
6. Explain process of transcription in prokaryotes.
--- Content provided by FirstRanker.com ---
Add a note on post transcriptional modification andinhibitors of transcription. (20)
7. Explain why (10)
a. Vitamin E act as an antioxidant
b. Telomerase have been implicated in aging process
--- Content provided by FirstRanker.com ---
and cancers.c. Oedema is major manifestation in kwashiorkor.
d. Methotrexate is used an anti cancer agent
e. Genetic code is specific (A. 547)
f. Serum creatinine is more sensitive para meter than
--- Content provided by FirstRanker.com ---
urea for assessing renal function.8. Explain briefly: (20)
a. Operon concept of gene regulation
b. Salient features of genetic code
c. Application of recombinant DNA technology
--- Content provided by FirstRanker.com ---
d. Antioxidant enzymes***