Date: 12-03-2022
RUHS
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPER II
Time: 3 hours

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Max Marks: 100
Instructions: INSTRUCTIONS: Attempt all
questions in both sections: (Use separate
answer book for each section)
Section 1

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1. Fill in the blanks (6)
a. The Northern blot is used to demonstrate
specific ___________
b. Cereals are deficient in ___________ amino
acid.

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c. The positive direct van den Bergh's reaction
indicates the presence of ___________
d. The Jumping gene is also known as
___________ element.
e. The normal value of urea clearance is

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___________

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f. Hyperventilation is a compensatory
2. Choose the correct option in the following
choice question: (4)
a. All of the following are the components of

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'Pre initiation complex' Except.
i. Enhances
ii. TF II D
iii. TATA box
iv. RNAP II

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b. Which of the following is not a mechanism
for mutation of DNA?
i. Substitution of nucleotide
ii. Dimerization of nucleotide
iii. Insertion of nucleotide

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iv. Deletion of nucleotide
c. Superoxide radicals can be detoxified by;
i. Cytochrome c
ii. Cytochrome b
iii. Cytochrome a

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iv. None
d. The following enzyme is widely used in
recombinant DNA technology.
i. DNA polymerase
ii. Telomerase

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iii. Restriction Endonuclease

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iv. None
3. A 45-year male complained of severe joint
pain especially in the big toes in the early
morning hours. The consultant decided to get

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his uric acid level in serum to be (15)
estimated which was 12.0 mg/dL. He was non-
vegetarian and alcoholic, he was asked to
restrict the non-vegetarian dict and alcohol.
a. What is the normal level of serum uric acid?

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b. What is the difference between primary gout
and secondary gout?
c. Explain the biochemical basis of the
symptoms in this patient.
d. How is the above disease treated?

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e. Why he was asked to restrict non-vegetarian
dict and alcohol?
4. Write short notes on (any five) (10)
a. Enlist the substrates of Gluconeogenesis
b. Ketosis

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c. Calcitriol
d. Lesch-Nyhan Syndrome (A. 399)
e. Anion Gap (A.482)
f. Transaminases
5. Explain briefly (Any three): (15)

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a. Krebs Henseleit Cycle
b. Catabolism of Purine and its disorders
c. Functions of vitamin C (A.136)
d. Chemiosmotic theory
Section 2

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6. Define lipoproteins with examples. Explain
the metabolism of HDL cholesterol and its role
in health and disease. (20)
7. Explain why (Any five): (10)
a. Neonates are more susceptible to develop

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Vitamin K deficiency.
b. Eating maize causes pellagra like symptoms.
c. Essential fatty acids helps in prevention of
fatty liver.
d. Hyperuricemia is associated with Von-

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Gierke's disease.
e. Direct bilirubin is increased in Obstructive
jaundice.
f. HbA1c is a good indicator of sugar control in
T2DM.

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8. Explain briefly (Any four): (20)
a. Isoenzymes. (A.114)
b. Laboratory diagnosis of diabetes mellitus.

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c. Maple syrup urine disease (A.367)
d. Antioxidant vitamins.

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e. Functions of calcium
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Document Outline

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