RUHS
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPERI
Date: 14-03-2022
Time:
Instructions: INSTRUCTIONS: Attempt al questions in both sections:
(Use separate answer book for each section)
Section 1
1. Fill in the blanks: (6)
__________
b. Accumulation__________in the lens of the eye causes cataracts
in type 2 diabetes mellitus.
c. In the biosynthesis of cholesterol, the rate-limiting enzyme is
d. The first pentose formed in HMP shunt is __________
e. __________ enzyme typically elevated in alcoholism.
2. Choose the correct option in the following multiple choice questions:
(4)
EXCEPT;
a) Glutamine
b) Glycine
c) Aspartate
b. Gamma-Glutamyl cysteinyl glycine is otherwise known as;
a) Oxytocin
b) Bradykinin
c) Glutathione
c. Which of the following is the key regulator enzyme of heme
synthesis?
a) Porphobilinogen deaminase
b) PBG Synthase
d) ALA Synthase
d. The amino acid which is associated with atherosclerosis is,
a) Lysine
b) Alanine
d) Homocysteine
3. A 35-year-old woman visited OPD with complaints of excessive
menstrual bleeding. She also complained of lethargy, giddiness,
excessive tiredness, and (15) breathlessness on walking. Since the
decreased. She was a pure diagnosis of iron deficiency vegetarian.
Based on the clinical history and blood reports, anaemia was made
and treatment started with ferrous sulphate and vitamin C.
a. What are the dietary sources of iron? Give daily requirements of
b. What are the causes of iron deficiency anaemia?
c. Why vitamin C is given to this patient? Explain the role of Vitamin
C in iron metabolism.
d. Why iron metabolism is called as one-way metabolism?
examples of iron-containing enzymes?
4. Write short notes on: (10)
a. Significance of NADPH.
b. Renal mechanism for acid base regulation.
d. Complications of diabetes mellitus (A.654)
e. Ketogenesis and ketolysis. (A.295)
5. Explain briefly (Any three): (15)
a. Alcohol Metabolism.
b. Difference between hemoglobin and Myoglobin.
c. Phenylketonuria (A.352)
d. Clinical importance of competitive enzyme inhibition.
Section 2
1. Beta oxidation of Long-Chain Saturated fatty acid (Palmitic acid -
2. Explain Why (Any fivc): (10)
a. Blood buffers act quickly but not permanently. (A.476)
b. Primaquine administration in G6PD deficient patients can
precipitate Hemolytic anaemia.
bulb/vial.
d. Hyaluronidase is called as spreading factor.
e. A single intramuscular dose of Vitamin K is given to all newborns.
f. Deficiency of Lipoprotein lipase results in Hypertriglyceridemia.
a. Cori's cycle.
b. Lung surfactant and respiratory distress syndrome.
c. Fatty liver - definition and causes.
d. Pellagra.
***
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPERI
Date: 14-03-2022
Time:
--- Content provided by FirstRanker.com ---
3 hours Max Marks: 100Instructions: INSTRUCTIONS: Attempt al questions in both sections:
(Use separate answer book for each section)
Section 1
1. Fill in the blanks: (6)
--- Content provided by FirstRanker.com ---
a. The ammonium ions excreted into urine are derived from__________
b. Accumulation__________in the lens of the eye causes cataracts
in type 2 diabetes mellitus.
c. In the biosynthesis of cholesterol, the rate-limiting enzyme is
--- Content provided by FirstRanker.com ---
__________d. The first pentose formed in HMP shunt is __________
e. __________ enzyme typically elevated in alcoholism.
2. Choose the correct option in the following multiple choice questions:
(4)
--- Content provided by FirstRanker.com ---
a. All of the following amino acids contribute to purine synthesisEXCEPT;
a) Glutamine
b) Glycine
c) Aspartate
--- Content provided by FirstRanker.com ---
d) Cysteineb. Gamma-Glutamyl cysteinyl glycine is otherwise known as;
a) Oxytocin
b) Bradykinin
c) Glutathione
--- Content provided by FirstRanker.com ---
d) Angiotensinc. Which of the following is the key regulator enzyme of heme
synthesis?
a) Porphobilinogen deaminase
b) PBG Synthase
--- Content provided by FirstRanker.com ---
c) Uroporphyrinogen III Synthased) ALA Synthase
d. The amino acid which is associated with atherosclerosis is,
a) Lysine
b) Alanine
--- Content provided by FirstRanker.com ---
c) Cysteined) Homocysteine
3. A 35-year-old woman visited OPD with complaints of excessive
menstrual bleeding. She also complained of lethargy, giddiness,
excessive tiredness, and (15) breathlessness on walking. Since the
--- Content provided by FirstRanker.com ---
past few months, her physical performance had significantlydecreased. She was a pure diagnosis of iron deficiency vegetarian.
Based on the clinical history and blood reports, anaemia was made
and treatment started with ferrous sulphate and vitamin C.
a. What are the dietary sources of iron? Give daily requirements of
--- Content provided by FirstRanker.com ---
iron (RDA) for adults?b. What are the causes of iron deficiency anaemia?
c. Why vitamin C is given to this patient? Explain the role of Vitamin
C in iron metabolism.
d. Why iron metabolism is called as one-way metabolism?
--- Content provided by FirstRanker.com ---
e. What is the biochemical role (functions) of Iron. Give twoexamples of iron-containing enzymes?
4. Write short notes on: (10)
a. Significance of NADPH.
b. Renal mechanism for acid base regulation.
--- Content provided by FirstRanker.com ---
c. Regulation of Blood calcium level.d. Complications of diabetes mellitus (A.654)
e. Ketogenesis and ketolysis. (A.295)
5. Explain briefly (Any three): (15)
a. Alcohol Metabolism.
--- Content provided by FirstRanker.com ---
b. Difference between hemoglobin and Myoglobin.
c. Phenylketonuria (A.352)
d. Clinical importance of competitive enzyme inhibition.
Section 2
1. Beta oxidation of Long-Chain Saturated fatty acid (Palmitic acid -
--- Content provided by FirstRanker.com ---
16c) and explain energy production from it. (20)2. Explain Why (Any fivc): (10)
a. Blood buffers act quickly but not permanently. (A.476)
b. Primaquine administration in G6PD deficient patients can
precipitate Hemolytic anaemia.
--- Content provided by FirstRanker.com ---
c. For estimation of blood sugar, blood is collected in a fluoridebulb/vial.
d. Hyaluronidase is called as spreading factor.
e. A single intramuscular dose of Vitamin K is given to all newborns.
f. Deficiency of Lipoprotein lipase results in Hypertriglyceridemia.
--- Content provided by FirstRanker.com ---
3. Explain briefly (Any four): (20)a. Cori's cycle.
b. Lung surfactant and respiratory distress syndrome.
c. Fatty liver - definition and causes.
d. Pellagra.
--- Content provided by FirstRanker.com ---
e. Wilson's disease.***