KALOJI NARAYANA RAO UNIVERSITY OF HEALTH SCIENCES
WARANGAL, TELANGANA STATE ? 506 002
MBBS FIRST YEAR EXAMINATIONS: SEPTEMBER,2025
BIOCHEMISTRY
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PAPER ? ITime: 3 Hours
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Max Marks: 100
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Note: Answer all questionsGive Diagrammatic representation wherever necessary
Multiple Choice Questions:
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10 X 1 = 10
1. Which one of the following statement is correct regarding HDL ( High density
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lipoprotein )
a) It transport dietary lipids from
b) It transports endogenous lipids from
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the intestine to various tissuesthe liver to the peripheral tissues
c) It transports cholesterol from the d) It transports the fatty acids released
peripheral tissues to the liver
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by lipolysis2. During starvation, the brain derives most of its energy needs by utilizing the
following
a) Fatty acids
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b) Ketone bodiesc) Amino acids
d) Glucose
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3. Enzymes catalyzing electron transport are present mainly in thea) Ribosomes
b) Endoplasmic reticulum
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c) Lysosomesd) Inner mitochondrial membrane
4. The carbohydrate of the blood group substances is
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a) Sucroseb) Fucose
c) Arabinose
d) Maltose
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5. Fluoride inhibits_____and arrests glycolysis.
a) Glyceraldehyde-3-phosphate
b) Aconitase
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dehydrogenase
c) Enolose
d) Succinate DH
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6. All the following statements about carnitine are true excepta) It can be synthesized in the
b) It can be synthesized from
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human bodymethionine and lysine
c) It is required for transport of
d) Its deficiency can occur due to
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short chain fatty acids intohaemodialysis
mitochondria
7. Lieberman-Burchard reaction is performed to detect
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a) Cholesterolb) Glycerol
c) Fatty acid
d) Vitamin D
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8. The active form of vitamin D is
a) 1, 25 --DHCC
b) 1,24 -- DHCC
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c) 24,25 -- DHCC
d) 25- HCC
9. Kwashiorkor occurs when the diet is severely deficient in
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a) Iron
b) Calories
c) Proteins
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d) Essential fatty acids10. Keshan disease occurs due to the deficiency of
a) Selenium
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b) Chromiumc) Cobalt
d) Manganese
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Essay/ Long Answer Questions:2 X 15 = 30
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11. A 60-year-old male presented with acute chest pain of ? hour duration. His past history revealsas a known diabetic; known hypertensive, known smoker and known alcoholic. The
biochemical analysis are as follows:
Blood glucose = 380 mg%, Serum cholesterol = 300 mg%
AST = 60 U/L, ALT= 15 U/L, CPK & LDH were elevated.
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a) Give your provisional diagnosis and meaning of it.b) Explain in detail about cardiac markers with graph patterns.
c) What are the other markers which can be estimated in this case.
d) Write the normal values of all of the above lab tests.
(3+5+3+4)
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12.Write in detail on the metabolism of Iron- the essential trace element in the following headingsa) What are the other essential trace elements, name them?
b) Describe the dietary source, daily requirement, factors affecting `Fe' absorption,
transport, storage, biochemical functions and deficiency manifestations of the mineral.
c) Specially explain the mucosal block theory of Iron absorption to support the statement ?
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Iron is a one-way element.(1+10+4)
Short Answer Questions:
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7 X 6 = 42
13. Write about the structural and functional organization of electron transport chain. Add a note on
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inhibitors of it.14. Write about Ketone body's synthesis and discuss the importance.
15. Describe the role of a physician in health care system
16. Discuss in detail on the regulation of blood glucose level (Homeostasis of blood glucose level)
and define hypoglycaemia. Write in detail on various causes of Hypoglycaemia.
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17. Define phospholipids. State their function and importance.18. Write in detail on the biochemical function, RDA, and deficiency manifestations of Vitamin A.
19. Discuss in detail on the transport mechanisms/process across the cell membranes.
Very Short Answer Questions:
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6 X 3 = 18
20. What is the principle, procedure and clinical application of radio immunoassay.
21. Mention biological active form of folic acid. How is it involved in one carbon metabolism?
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22. Polysaccharides.23. Vitamin K cycle ? biochemical function of vitamin K.
24. Glycogen storage disorders.
25. Biochemical function of selenium.
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